THE PLASMA LEVEL OF PARATHORMON AND HOMOCYSTEINE IN MIGRAINE PATIENTS; ANOTHER ASPECT ON MIGRAINE-STROKE ASSOCIATON

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dc.contributor.authorVarol, Sefer
dc.contributor.authorAkil, Esref
dc.contributor.authorYunce, Muharrem
dc.contributor.authorKaplan, Brahim
dc.contributor.authorOzdemir, Hasan Huseyin
dc.contributor.authorArslan, Demet
dc.contributor.authorYilmaz, Ahmet
dc.date.accessioned2024-04-24T17:44:50Z
dc.date.available2024-04-24T17:44:50Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe pathogenesis of migraine has been well studied and it is associated with oxidative stress, neurogenic inflammation, and endothelial dysfunction. To the best of our knowledge, no studies have focused on the impact of the parathormone (PTH) and homocysteine levels in migrane patients. To determine migraine-stroke association, our study focused on the levels of PTH and homocysteine in the blood of migraine patients. Fifty five migraine patients in the presence or absence of aura were included. The patients in the migraine group were divided into subgroups: (I) migraine in the attack period (with and without aura) (n = 23), and (II) migraine in the interictal period (with and without aura) (n = 32). As a control, 30 healthy volunteers were also enrolled in the study. As a result, we found that PTH and homocysteine levels of the migraine patients were increased significantly when compared with healthy volunteers (p = 0.001). The PTH and homocysteine levels of the patients with aura were higher than patients without aura in the migraine group (p < 0.05). There were no statistically significant differences between PTHIhomocysteine levels and migraine duration or migraine attack frequency (p > 0.05). There was a positive correlation between PTH and homocysteine levels in the migraine patients (p = 0.001, r = 0.49). To summarize, we found statistically significant increases in PTH and homocysteine blood levels of migraine patients versus healthy volunteers. These results may help to understand the pathogenesis of migraine ischemia, and potentially identify new prognostic markers for this condition.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship about English editing of this manuscript.en_US
dc.identifier.endpage733en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue3en_US
dc.identifier.startpage729en_US
dc.identifier.urihttps://hdl.handle.net/11468/22310
dc.identifier.volume31en_US
dc.identifier.wosWOS:000357001100029
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectPathogenesisen_US
dc.subjectParathyroid Hormoneen_US
dc.subjectHomocysteineen_US
dc.titleTHE PLASMA LEVEL OF PARATHORMON AND HOMOCYSTEINE IN MIGRAINE PATIENTS; ANOTHER ASPECT ON MIGRAINE-STROKE ASSOCIATONen_US
dc.titleTHE PLASMA LEVEL OF PARATHORMON AND HOMOCYSTEINE IN MIGRAINE PATIENTS; ANOTHER ASPECT ON MIGRAINE-STROKE ASSOCIATON
dc.typeArticleen_US

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