Anti-inflammatory and anti-oxidant role of ursolic acid in cerulein-induced acute pancreatitis in rats

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dc.contributor.authorTurkoglu, Ahmet
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorArslan, Serkan
dc.contributor.authorHalil-Ocal, Ibrahim
dc.contributor.authorGumus, Metehan
dc.date.accessioned2024-04-24T17:20:21Z
dc.date.available2024-04-24T17:20:21Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Ursolic acid (UA) is found in many plants, and has been reported to have anti-protease, antioxidant, anti-inflammatory, antimicrobial, nephroprotective, hepatoprotective, and cardioprotective effects. Objective: The purpose of this study was to investigate the effects of ursolic acid in cerulein-induced acute pancreatitis (AP). Materials and methods: Thirty-two Wistar albino rats were randomly assigned to 4 equal groups: Sham, acute pancreatitis, treatment, and ursolic acid group. Results: Serum amylase levels in the AP and treatment groups were significantly higher than in the others (p < 0.05). In addition, serum IL-113, IL-6, and TNF-& alpha; levels were significantly higher in the AP group in comparison with the treatment group. Although pancreatic tissue total oxidant activity in the AP and treatment groups was similar, pancreatic tissue total antioxidant capacity was significantly higher in the treatment group than in the AP group. Conclusions: Damage to the pancreas and remote organs in AP was observed to be reduced by UA. In addition, oxidative stress was observed to be decreased by the effect of UA.en_US
dc.description.sponsorship[DUBAP 2013/07]en_US
dc.description.sponsorshipFinanciamiento Se recibio el financiamiento para el proyecto DUBAP 2013/07.en_US
dc.identifier.doi10.24875/GMM.M23000782
dc.identifier.endpage351en_US
dc.identifier.issn0016-3813
dc.identifier.issue4en_US
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.24875/GMM.M23000782
dc.identifier.urihttps://hdl.handle.net/11468/18975
dc.identifier.volume159en_US
dc.identifier.wosWOS:001052778700009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherAcad Nacional Medicina Mexicoen_US
dc.relation.ispartofGaceta Medica De Mexico
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrsolic Aciden_US
dc.subjectTotal Oxidant Activityen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectCeruleinen_US
dc.subjectAcute Pancreatitisen_US
dc.titleAnti-inflammatory and anti-oxidant role of ursolic acid in cerulein-induced acute pancreatitis in ratsen_US
dc.titleAnti-inflammatory and anti-oxidant role of ursolic acid in cerulein-induced acute pancreatitis in rats
dc.typeArticleen_US

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