ICE Regimen in Adult Advanced/Relapsed Soft TissueSarcoma Patients; is it More Effective in Early Use?Retrospective Analysis of Single Center Study

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dc.contributor.authorSezgin, Yasin
dc.contributor.authorEbinç, Senar
dc.contributor.authorIşıkdoğan, Abdurrahman
dc.contributor.authorKüçüköner, Mehmet
dc.contributor.authorKaplan, Muhammet Ali
dc.contributor.authorOruç, Idris
dc.contributor.authorUrakci, Zuhat
dc.date.accessioned2024-04-24T19:13:03Z
dc.date.available2024-04-24T19:13:03Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives: To analyze the efficacy and tolerability of the ICE regimen and prognostic factors for survival in patientswith advanced or relapsed soft tissue sarcomas treated with the ICE regimen (ifosfamide, carboplatin and etoposide). Methods: The records of 28 patients diagnosed with advanced or relapsed soft tissue sarcoma who were treated withthe ICE regimen at our center between 2008 and 2020, were evaluated retrospectively. Results: The most common histopathological subtype were pleomorphic sarcoma (9/32.1%). After a median follow-upduration of 8 months, the median PFS and OS were 6 months (95% confidence interval (CI), 3.6–8.3) and 9.3 months(95% CI, 4.7–13.9), respectively. A multivariate analysis for overall survival revealed the ICE treatment line (HR:4.8, 95%Cl 1.7–12.8, p: 0.002), tumor site (HR: 0.12, 95% Cl 0.03–0.4, p: 0.001) and response to ICE regimen (HR: 0.09, 95% Cl0.01–0.49, p: 0.005) to be independent prognostic factors. The group that received 1–2 chemotherapy regimens priorto the ICE regimen recorded better OS than the group received more than two chemotherapy regimens (22.8 monthsvs 5 months, p: 0.006). Conclusion: The ICE regimen may be particularly effective when used for early treatment after doxorubicin-basedtherapy in patients with advanced or relapsed soft tissue sarcomas.en_US
dc.identifier.doi10.14744/ejmi.2021.30532
dc.identifier.endpage282en_US
dc.identifier.issn2602-3164
dc.identifier.issue2en_US
dc.identifier.startpage274en_US
dc.identifier.trdizinid484838
dc.identifier.urihttps://doi.org/10.14744/ejmi.2021.30532
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/484838
dc.identifier.urihttps://hdl.handle.net/11468/28299
dc.identifier.volume5en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Medical Investigation
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleICE Regimen in Adult Advanced/Relapsed Soft TissueSarcoma Patients; is it More Effective in Early Use?Retrospective Analysis of Single Center Studyen_US
dc.titleICE Regimen in Adult Advanced/Relapsed Soft TissueSarcoma Patients; is it More Effective in Early Use?Retrospective Analysis of Single Center Study
dc.typeArticleen_US

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