Use of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemia

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dc.contributor.authorC¸alis¸kan A.
dc.contributor.authorYazici S.
dc.contributor.authorKarahan O.
dc.contributor.authorGü?lü O.
dc.contributor.authorTezcan O.
dc.contributor.authorDemirtas¸ S.
dc.contributor.authorYildiz B.
dc.date.accessioned2024-04-24T17:58:28Z
dc.date.available2024-04-24T17:58:28Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: In this experimental study, alterations in plasma C-type natriuretic peptide (CNP) levels were evaluated during the critical initial hours of peripheral ischemia. Methods: Forty male Sprague-Dawley type rats (aged 8 to 12 weeks, weighing 230±30 g) were included in the study. Four groups were created with 10 rats namely control group, group 1, group 2, and group 3. Baseline plasma CNP levels were detected in the control group without any intervention, while the plasma CNP levels were determined in the second hour of peripheral ischemia in group 1. Plasma CNP levels were determined in the fifth hour of peripheral ischemia for group 2, whereas plasma CNP levels were determined in group 3 at the eighth hour of peripheral ischemia. Results: The baseline plasma CNP levels were 0.285±0.011 pmol/L in the control group. In rats with peripheral ischemia, a significant time-dependent increase was detected in plasma levels of CNP (p<0.05). The plasma CNP levels were detected as 0.350±0.015, 0.486±0.084, and 0.534±0.048 pmol/L in group 1, 2, and 3 respectively. Conclusion: Plasma CNP, an endothelium-derived vasodilator, is associated with the cellular response in ischemic tissues in a time-dependent manner.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2014.9378
dc.identifier.endpage619en_US
dc.identifier.issn1301-5680
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84907255903
dc.identifier.scopusqualityQ3
dc.identifier.startpage615en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2014.9378
dc.identifier.urihttps://hdl.handle.net/11468/23943
dc.identifier.volume22en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherBaycinar Medical Publishingen_US
dc.relation.ispartofTurkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectC-Type Natriuretic Peptideen_US
dc.subjectIschemic Responseen_US
dc.subjectPeripheral İschemiaen_US
dc.titleUse of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemiaen_US
dc.titleUse of C-type natriuretic peptide as an indicator in detection of inducible peripheral ischemia
dc.typeArticleen_US

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