Etiology and Histopathology of Alzheimer’s Disease and Current Approaches

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dc.contributor.authorErdemci, Fikri
dc.contributor.authorAşır, Fırat
dc.contributor.authorTaş, Fatih
dc.date.accessioned2025-03-08T18:25:57Z
dc.date.available2025-03-08T18:25:57Z
dc.date.issued2022
dc.departmentDicle Üniversitesi
dc.description.abstractAlzheimer’s disease (AD) is a widespread kind of dementia and is one of progressive neurodegenerative diseases that leads to permanent damage to neurons. It has known that genetic and non-genetic factors play a role in the etiopathogenesis of AD. The accepted genetic factors are mutations on genetic codes especially on PSEN1, PSEN2, and APP genes. However, non-genetic factors include advanced age, exposure to occupational factors, current disorders, and lifestyle characteristics of the person. The final AD diagnosis can establish by histopathological examination of the brain after death. Pathologically, AD has two distinguishing features. Of these, beta-amyloid (Aß) neurotic plaques are protein aggregates outside of nerve cells in the brain, whereas neurofibrillary tangles are structures found inside cells. The main component of amyloid plaques is Aß, and the main component of neurofibrillary tangles is tau protein. Despite current therapies for Alzheimer’s disease, no definitive treatment is available. Today, preventive and curative treatment approaches for the disease include cholinesterase inhibitors, neurotrophic factors, NMDA-receptor antagonists, HMG-CoA reductase inhibitors, non-steroidal anti-inflammatory drugs, estrogen replacement therapies, antioxidants, and regular sleep. Despite all these approaches for the disease, further multidisciplinary studies are needed for the definitive treatment of the disease.
dc.identifier.doi10.19127/bshealthscience.1064168
dc.identifier.endpage327
dc.identifier.issn2619-9041
dc.identifier.issue2
dc.identifier.startpage322
dc.identifier.urihttps://doi.org/10.19127/bshealthscience.1064168
dc.identifier.urihttps://hdl.handle.net/11468/30483
dc.identifier.volume5
dc.language.isoen
dc.publisherCem TIRINK
dc.relation.ispartofBlack Sea Journal of Health Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_21250205
dc.subjectAlzheimer’s disease
dc.subjectDementia
dc.subjectBeta-amyloid
dc.subjectTau protein
dc.titleEtiology and Histopathology of Alzheimer’s Disease and Current Approaches
dc.typeReview Article

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