Assessment of the protective effects of pomegranate peel extract and N-acetyl cysteine alone or in combination with Ornipural® against Cadmium-induced bone toxicity in rat

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dc.contributor.authorHatipoglu, Durmus
dc.contributor.authorDemircioglu, İsmail
dc.contributor.authorFilikci, Kursat
dc.contributor.authorKorkmaz, Yasemin
dc.contributor.authorGungor, Huseyin
dc.contributor.authorDemircioglu, Muhammed
dc.contributor.authorDik, Burak
dc.date.accessioned2025-02-22T14:18:00Z
dc.date.available2025-02-22T14:18:00Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: The present study was conducted to determine the effects of pomegranate peel extract (PPE) and N-acetyl Cysteine (NAC) alone or in their treatment combinations with commercial preparation Ornipural® (ORN) on bone metabolism against experimentally cadmium (Cd)-induced toxicity in rats. Materials and Methods: Totally 36 animals were used in the study including 6 Wistar Albino rats in each group. The animals were assigned to control, Cd, Cd+PPE, Cd+NAC, Cd+PPE+ORN and Cd+NAC+ORN groups. The animals in the groups were euthanized after their blood samples were taken at the end of the 8th week. The bones were subjected to maceration for morphometric and histopathological examinations after euthanasia. Results: The statistically significant differences were determined between the treatment groups and Cd group in terms of histopathological changes (osteoporotic alterations and changes in red bone marrow) and biomarkers (Ca, P and Mg) (P<0.05). Conclusion: Although PPE, NAC and treatment combinations with ORN applied against experimentally induced cadmium toxicity were determined to have positive effects on bone metabolism, it has been thought that carrying out trials by increasing treatment duration and dose would be beneficial to determine definite efficacy of the applied treatment protocols.en_US
dc.identifier.doi10.15312/EurasianJVetSci.2024.422
dc.identifier.endpage33en_US
dc.identifier.issn1309-6958
dc.identifier.issn2146-1953
dc.identifier.issue1en_US
dc.identifier.startpage24en_US
dc.identifier.trdizinid1228195en_US
dc.identifier.urihttps://doi.org/10.15312/EurasianJVetSci.2024.422
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1228195
dc.identifier.urihttps://hdl.handle.net/11468/30204
dc.identifier.volume40en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Veterinary Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectCadmiumen_US
dc.subjectpomegranate peelen_US
dc.subjectBone toxicityen_US
dc.subjectN-acetyl cysteineen_US
dc.subjectOrnipural®en_US
dc.titleAssessment of the protective effects of pomegranate peel extract and N-acetyl cysteine alone or in combination with Ornipural® against Cadmium-induced bone toxicity in raten_US
dc.typeArticleen_US

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