Kolorektal kanserde serum vasküler endotelyal büyüme faktör (VEGF) düzeylerinin bilinen prognostik faktörlerle ilişkisi
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2007
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info:eu-repo/semantics/closedAccess
Özet
GİRİŞ: Kolorektal kanserler (KRK) gelişmiş ülkelerde en sık görülen kanser tiplerinden biri olup görülme sıklığı giderek artış göstermektedir. KRK'li bir hastada uygun tedaviyi planlamak için hastalığın prognozu hakkında bilgiye gereksinim duyulur. Anjiyogenesiz KRK'in ilerlemesinde önemli bir rol oynar. Preklinik ve klinik çalışmalardaki kanıtlar VEGF' ün insan KRK'inde temel anjiyogenik faktör olduğunu ve metastazların oluşumu ve kötü prognozla ilişkili olduğunu göstermiştir. Yaptığımız çalışmanın amacı KRK'li hastalarda VEGF seviyelerini ve bunun hastalığın diğer klinikopatolojik özellikleri ile olan ilişkisini analiz etmektir YÖNTEM: Çalışmaya preoperatif ve /veya postoperatif kemoterapi ve/veya radyoterapi almamış 71 hasta alındı. Hastaların serum VEGF seviyeleri evre, yaş, cinsiyet, lokalizasyon, metastaz ve CEA ya göre analiz edildi. BULGULAR: Evre III?IV deki hastaların VEGF değerleri Evre I?II deki hastaların değerleri karşılaştırıldığında anlamlı bir şekilde (p<0,003) yüksek bulundu. Kolon lokalizasyonuna sahip hastaların VEGF seviyeleri ile rektum kanserli hastaların seviyeleri arasında istatistiki olarak anlamlı bir fark saptanmadı (p=0.266). VEGF'ün salınımı CEA düzeyleri (p<0,01) ve klinik evre ile korele bulundu (p<0,01). VEGF salınımı ile hastanın yaşı ( p=0.955) ve cinsiyeti (p = 0,740) arasında korelasyon bulunmadı. SONUÇ: VEGF salınımının hastalığın evresi ve metastaz ile anlamlı bir şekilde korele olduğu bulunurken bu ilişki hastanın yaşı, cinsiyeti ve tümörün lokalizasyonunda gösterilemedi. VEGF düzeyi KRK'in progresyonunda ve metastazında önemli bir rol oynayabilir. Bu nedenle VEGF, KRK'de bir prognostik belirteç olarak kullanılabilir ve noninvazif bir ölçüm olarak hastalığın klinik durumu hakkında bize bilgi verebilir. Anahtar kelimeler: Anjiyogenezis, VEGF, Kolorektal kanser
BACKGROUND: Colorectal cancer is one of the most common forms of cancer in developed nations, and the incidence of this disease is continuing to increase. A clinician encountering patients with colorectal cancer needs to know the prognostic factor expected outcome to plan appropriate therapy. There are numerous variables being related to survival. Angiogenesis plays an important role in colorectal cancer progression. Evidence from preclinical and clinical studies indicates that vascular endothelial growth factor (VEGF) is the predominant angiogenic factor in human colorectal cancer and is associated with formation of metastases and poor prognosis. The aim of the presented study is to analyze serum VEGF levels and its correlation with the other clinicopathological characteristics of patients with colorectal carcinoma. METHODS: 71 patient with colorectal adenocarcinoma were evaluated by estimation of VEGF and correlation with clinicopathological features. None of the patients received pre- and/or post-operative chemo- and/or radiotherapy. The results of serum VEGF were analysed with respect to stage, gender, age, CEA, metastases and topographical tumour localization. RESULTS: Patients with stage 3?4 disease had significantly (P<0.003) higher values of VEGF than patients with stage 1?2, who had comparable values. Patients with the primary tumour localized in the colon had no significantly (P=0.266.) higher levels of serum VEGF than patients with the primary tumour localized in the rectum. The VEGF expression significantly correlated with serum CEA level ( p< 0.01) and clinical stages of CRC (p<0.01 ). The VEGF expression was not correlated with patient ages (p =0.955) and gender (p =0.740). CONCLUSION: The VEGF expression was found significantly correlated with advanced stage, and metastases but not age, gender, and tumour localization. VEGF may play an important role in the invasion and metastasis of CRC. Therefore, VEGF could be applied as prognostic markers in CRC and measurement of VEGF in the serum may be a useful noninvasive clinical marker for evaluating the disease status. Keywords: Angiogenesis, VEGF, Colorectal cancer
BACKGROUND: Colorectal cancer is one of the most common forms of cancer in developed nations, and the incidence of this disease is continuing to increase. A clinician encountering patients with colorectal cancer needs to know the prognostic factor expected outcome to plan appropriate therapy. There are numerous variables being related to survival. Angiogenesis plays an important role in colorectal cancer progression. Evidence from preclinical and clinical studies indicates that vascular endothelial growth factor (VEGF) is the predominant angiogenic factor in human colorectal cancer and is associated with formation of metastases and poor prognosis. The aim of the presented study is to analyze serum VEGF levels and its correlation with the other clinicopathological characteristics of patients with colorectal carcinoma. METHODS: 71 patient with colorectal adenocarcinoma were evaluated by estimation of VEGF and correlation with clinicopathological features. None of the patients received pre- and/or post-operative chemo- and/or radiotherapy. The results of serum VEGF were analysed with respect to stage, gender, age, CEA, metastases and topographical tumour localization. RESULTS: Patients with stage 3?4 disease had significantly (P<0.003) higher values of VEGF than patients with stage 1?2, who had comparable values. Patients with the primary tumour localized in the colon had no significantly (P=0.266.) higher levels of serum VEGF than patients with the primary tumour localized in the rectum. The VEGF expression significantly correlated with serum CEA level ( p< 0.01) and clinical stages of CRC (p<0.01 ). The VEGF expression was not correlated with patient ages (p =0.955) and gender (p =0.740). CONCLUSION: The VEGF expression was found significantly correlated with advanced stage, and metastases but not age, gender, and tumour localization. VEGF may play an important role in the invasion and metastasis of CRC. Therefore, VEGF could be applied as prognostic markers in CRC and measurement of VEGF in the serum may be a useful noninvasive clinical marker for evaluating the disease status. Keywords: Angiogenesis, VEGF, Colorectal cancer
Açıklama
Anahtar Kelimeler
Anjiyogenezis, Angiogenesis, VEGF, Kolorektal kanser, Colorectal cancer, Onkoloji, Oncology
