Comparison of effects of iloprost and pentoxiphylline on walking capacity and skin oxygenation in diabetic patients with peripheral artery disease

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dc.contributor.authorTopal, Askin Ender
dc.contributor.authorEren, Mehmet Nesimi
dc.date.accessioned2024-04-24T17:28:09Z
dc.date.available2024-04-24T17:28:09Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractDiabetes is in close relation with peripheral artery disease (PAD) and there are conflicting results regarding efficacy of iloprost in PAD. The aim of this study was to investigate the efficacy of iloprost in improving walking capacity and increasing oxygenation to diseased tissues in PAD patients with diabetes, compared to pentoxiphylline. Data of 80 patients were recorded contemporaneously. Patients were divided into two groups (Group 1: Users of iloprost and pentoxiphylline; Group 2: Users of only pentoxiphylline). O-2 saturations in diseased limbs were significantly improved at three-months follow-up in both groups (both p<0.001). The difference between groups was in favor of Group 1 (p = 0.012). Maximum walking capacity was also increased significantly in both groups (both p<0.001). However, the improvements in walking distance were at similar extent (p = 0.226). In comparison with pentoxiphylline, iloprost has no superior effect on walking capacity of diabetic patients with intermittent claudication. However, iloprost improves oxygenation of tissues better than pentoxiphylline, therefore iloprost may be preferred especially in diabetic patients with critical limb ischemia as an adjunctive therapy followed by pentoxiphylline or cilostazol. Usage of iloprost may contribute to the recovery of diabetic ulcers and also, it may postpone occurrence of diabetic ulcers.en_US
dc.identifier.doi10.5897/AJPP11.313
dc.identifier.endpage299en_US
dc.identifier.issn1996-0816
dc.identifier.issue5en_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://doi.org/10.5897/AJPP11.313
dc.identifier.urihttps://hdl.handle.net/11468/20346
dc.identifier.volume6en_US
dc.identifier.wosWOS:000303761200003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherAcademic Journalsen_US
dc.relation.ispartofAfrican Journal of Pharmacy and Pharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectIloprosten_US
dc.subjectPentoxiphyllineen_US
dc.subjectWalking Capacityen_US
dc.subjectOxygen Saturationen_US
dc.titleComparison of effects of iloprost and pentoxiphylline on walking capacity and skin oxygenation in diabetic patients with peripheral artery diseaseen_US
dc.titleComparison of effects of iloprost and pentoxiphylline on walking capacity and skin oxygenation in diabetic patients with peripheral artery disease
dc.typeArticleen_US

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