Effects of urokinase on postoperative intraabdominal adhesion formation and healing of bowel anastomosis

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dc.contributor.authorOtcu S.
dc.contributor.authorOnen A.
dc.contributor.authorDokucu A.I.
dc.contributor.authorOzer M.
dc.contributor.authorIsik B.
dc.contributor.authorDeveci E.
dc.contributor.authorOzdemir E.
dc.date.accessioned2024-04-24T17:58:53Z
dc.date.available2024-04-24T17:58:53Z
dc.date.issued1997
dc.departmentDicle Üniversitesien_US
dc.description.abstractUrokinase with its' proteolytic enzyme activity, has been frequently used in experimental studies on postoperative intraperitoneal adhesion formation. As wound healing process may be effected with the same mechanism, we aimed to investigate if intraperitoneal administration of urokinase increases the rate of anastomotic complications. For every ten rats of the control and urokinase group, laparotomy and colonic anastomosis are performed. In the urokinase group abdominal cavities are irrigated with 2000 IU of urokinase. All the rats are sacrificed at postoperative seventh day and adhesion scoring, anastomosis bursting pressure and histopathological findings are investigated. There is no anastomotic leakage in both groups. Adhesion score in control group (2.6±0.52) was significantly higher than urokinase group (1.1±0.74). Differences in anastomotic bursting pressure between the groups were not statistically significant. Although serosal and mucosal continuity were not achieved properly due to excessive fibroblastic activity in control animals, it could be obtained in the urokinase group sufficiently. Our findings support the efficacy of urokinase in preventing the postoperative intraabdominal adhesion formation, while the healing process at the anastomotic site is not alter with its' intraperitoneal administration.en_US
dc.identifier.endpage63en_US
dc.identifier.issn1016-5142
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-0031387380en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://hdl.handle.net/11468/24142
dc.identifier.volume11en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofPediatrik Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Adhesionsen_US
dc.subjectIntestinal Anastomosisen_US
dc.subjectUrokinaseen_US
dc.subjectWound Healingen_US
dc.titleEffects of urokinase on postoperative intraabdominal adhesion formation and healing of bowel anastomosisen_US
dc.title.alternativeUrokinazin ameliyat sonrasi karin ici yapisikliklarinin olusumu ve barsak anastomozlarinin iyilesmesi uzerine etkilerien_US
dc.typeArticleen_US

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