Spectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin

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dc.contributor.authorTarkan, Nurettin
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorYiğit, Fatih
dc.contributor.authorErek, Figen
dc.contributor.authorAydın, Işıl
dc.date.accessioned2024-04-24T19:13:22Z
dc.date.available2024-04-24T19:13:22Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractAn easy and economical spectrophotometric method has been developed for the determination of atorvastatin from tablet formulation. This method is based on the formation of a blue-colored charge transfer complex of Atorvastatin with quinalizarin in methanol medium. The blue colored complex gives maximum absorbance at 573 nm. In order to develop the quantitative analysis method of atorvastatin, several parameters such as the type of solvent, the effect of reagent concentration, and the reaction time and temperature on absorbance of complex were investigated. It was determined that the optimum Quinz solution (0.5x10-³ M) was 3mL and the optimum temperature of the reaction was room temperature. Beer’s law range of proposed method is found 10-100 µg.mL-1. LOD and LOQ of the proposed method were found as 1.49 µg.mL-1 and 4.98 µg.mL-1, respectively. As a result, this proposed method can be used in the quantitative analysis of atorvastatin in tablet formulationsen_US
dc.identifier.doi10.17776/csj.1327163
dc.identifier.endpage715en_US
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue4en_US
dc.identifier.startpage710en_US
dc.identifier.trdizinid1215655
dc.identifier.urihttps://doi.org/10.17776/csj.1327163
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1215655
dc.identifier.urihttps://hdl.handle.net/11468/28570
dc.identifier.volume44en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSpectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarinen_US
dc.titleSpectrophotometric Determination of Atorvastatin Based on Charge Transfer Reaction with Quinalizarin
dc.typeArticleen_US

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