Investigation of Bax and Phospho-Tau Protein Expression in Preeclampsia Placenta

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dc.contributor.authorKaya, Seval
dc.contributor.authorAşır, Fırat
dc.contributor.authorAyaz, Hayat
dc.contributor.authorAğaçayak, Elif
dc.contributor.authorDeveci, Engin
dc.date.accessioned2025-02-22T14:13:32Z
dc.date.available2025-02-22T14:13:32Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Preeclampsia is a pregnancy complication with a high morbidity and mortality rate.BAX is a proapoptotic protein and in recent years, 14-3-3 tau proteins are considered as key regulators of many processes, such as apoptosis. In this study, we investigated the expression of phospho-tau and Bax in preeclampsia apoptosis immunohistochemically. Materials and Methods: 25 healthy and 25 preeclamptic pregnant placentas were included in the study. Placental samples were fixed with 10% neutral buffered formalin. Routine paraffin wax tissue protocol was used. Results: According to histological micrograf, the trophoblastic cells in the villi were normal in the control group. Mild dilatation in blood vessels was seen. Hyalinized and necrotic areas in chorionic villi and an increase in fibrinoid tissue in root villi were detected in preeclampsia sections. Phospho-tau and Bax primary antibodys were used for immunohistochemical evaluation. The sections from of the preeclampsia group were highly positive for syncytiotrophoblasts and villous connective tissue. It was also statistically different from the control group (p<0.05). Conclusions: When we evaluate the results shows that Phospho-tau and Bax may be determinant proteins in the apoptosis pathway of preeclampsia.en_US
dc.identifier.doi10.35440/hutfd.1337356
dc.identifier.endpage484en_US
dc.identifier.issn1304-9623
dc.identifier.issn1309-4025
dc.identifier.issue3en_US
dc.identifier.startpage477en_US
dc.identifier.trdizinid1219397en_US
dc.identifier.urihttps://doi.org/10.35440/hutfd.1337356
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1219397
dc.identifier.urihttps://hdl.handle.net/11468/30056
dc.identifier.volume20en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofHarran Üniversitesi Tıp Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectApoptosisen_US
dc.subjectpreeclampsiaen_US
dc.subjectbaxen_US
dc.subjectphospho-tauen_US
dc.titleInvestigation of Bax and Phospho-Tau Protein Expression in Preeclampsia Placentaen_US
dc.typeArticleen_US

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