The role of CA 72-4, a new tumor marker in gastric cancer

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dc.contributor.authorGöral V.
dc.contributor.authorYeşilbağdan H.
dc.contributor.authorKaplan A.
dc.contributor.authorŞit D.
dc.contributor.authorÇelik M.
dc.date.accessioned2024-04-24T18:43:40Z
dc.date.available2024-04-24T18:43:40Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Gastric cancer is among the most frequent malignancies throughout the world. Many studies are carried out with tumor markers, tumor suppressive genes and oncogenes in the diagnosis of gastric cancers and the prediction of prognosis. The role of CA 72-4, a new tumor marker in the diagnosis of gastric cancer, and the correlation between CA 72-4 and CA 19-9, CA 15-3, CA 125, carcinoembryonic antigen (CEA) were investigated in this study. Material and Methods: CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, erythrocyte sedimentation rate, AST, ALT, albumin and hematocrit values were examined in patients with gastric cancer. Age, sex, clinical manifestations, physical examination findings, localization (proximal/distal) and histological typing of the tumor according to Lauren classification, lymph node involvement, metastasis state, and tumor grade and the patient's performance status were evaluated. Results: Serum CEA, CA 19-9, CA 125, CA 15-3 levels were quite high in our study patients with gastric cancer. All patients whose CA 72-4 level was over 100 U/ml were advanced cases (grade IV). These 4 markers seemed to increase relatively consistently with tumor involvement and tumor grade. Although CA 72-4 is more sensitive, all other tumor markers except for CA 15-3 play an important role in the diagnosis and determining the prognosis in patients with gastric cancer. We determined that the serum CA 72-4 level in the group with cancer was significantly elevated with respect to the control group. This elevation was correlated with tumor expansion and tumor grade. Particularly in patients with liver metastases, CA 72-4 level was higher. Conclusion: We suggest that CA 72-4 level is a valuable parameter in determining the prognosis of gastric cancer and recommend its use as a laboratory test. Copyright © 2006 by Türkiye Klinikleri.en_US
dc.identifier.endpage8en_US
dc.identifier.issn1300-0292
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-33144458480en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3en_US
dc.identifier.urihttps://hdl.handle.net/11468/24283
dc.identifier.volume26en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGastric Canceren_US
dc.subjectTumor Markersen_US
dc.titleThe role of CA 72-4, a new tumor marker in gastric canceren_US
dc.title.alternativeMide kanserinde yeni bir tümör markeri olan CA 72-4'ün yerien_US
dc.typeArticleen_US

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