Thiol/Disulfide Homeostasis: A Potential New Peripheral Biomarker in Adolescent Depression

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dc.contributor.authorÖztürk, Masum
dc.contributor.authorÖzkan, Yekta
dc.contributor.authorSapmaz, Şermin Yalın
dc.contributor.authorErdal, Serkan
dc.contributor.authorTaneli, Fatma
dc.contributor.authorKandemir, Hasan
dc.date.accessioned2024-04-24T17:58:21Z
dc.date.available2024-04-24T17:58:21Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk ve Ergen Ruh Sağlığı Hastalıkları Anabilim Dalıen_US
dc.description.abstractBackground: Thiol-disulfide homeostasis (TDH), one of the most important antioxidants, is involved in the non-enzymatic removal of reactive oxygen molecules in the body and is one of the many methods to measure the level of oxidative stress (OS). In the present study, TDH is investigated in adolescent depression, and its relationship to clinical variables is examined. Methods: Thirty-two (50.0%) patients diagnosed with major depressive disorder (MDD) and without psychotropic drug use and 32 (50.0%) healthy controls were included in the present study. The subjects MDD and control groups were between 13 and 18 years old. Participants completed the DSM-5 Level-2 scales for depression and irritability. A colorimetric method proposed by Erel and Neselioglu was used to analyze the TDH parameters of serum samples. Results: Biochemical analyses of samples from the MDD and control groups showed significant differences between the groups in native thiol (SH) levels (P =.002), disulfide (SS) levels (P =.021), disulfide/total thiol (SS/ToSH) (P =.009), and disulfide/native thiol (SS/SH) (P =.003) levels. Analysis of receiver operating characteristic showed that the area under the curve values with “acceptable discrimination potential” for the TDH parameters were significantly able to discriminate individuals with MDD from healthy controls. Conclusion: Thiol-disulfide homeostasis, one of the OS parameters, was found to be impaired in adolescents with depression. Our results suggest that TDH may contribute to the etiopathogenesis of adolescent MDD and that TDH may be a novel approach to assess OS in adolescent depression. © 2024, AVES. All rights reserved.en_US
dc.description.sponsorship2020-017en_US
dc.description.sponsorshipFunding: This project was funded by Manisa Celal Bayar University Faculty of Medicine Scientific Research Projects Commission with the project number 2020-017. The funding source had no involvement in the study design, dataen_US
dc.identifier.citationÖztürk, M., Özkan, Y., Sapmaz, Ş. Y., Erdal, S., Taneli, F. ve Kandemir, H. (2024). Thiol/Disulfide homeostasis: A potential new peripheral biomarker in adolescent depression. Psychiatry and Clinical Psychopharmacology, 34(1), 29-37.
dc.identifier.doi10.5152/pcp.2024.23744
dc.identifier.endpage37en_US
dc.identifier.issn2475-0573
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85188539306
dc.identifier.scopusqualityQ4
dc.identifier.startpage29en_US
dc.identifier.urihttps://doi.org/10.5152/pcp.2024.23744
dc.identifier.urihttps://hdl.handle.net/11468/23861
dc.identifier.volume34en_US
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, Masum
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofPsychiatry and Clinical Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThiol/Disulfide Homeostasis: A Potential New Peripheral Biomarker in Adolescent Depressionen_US
dc.titleThiol/Disulfide Homeostasis: A Potential New Peripheral Biomarker in Adolescent Depression
dc.typeArticleen_US

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