Investigation of PLGF, sFlt-1 Expression in Placenta Previa, Placenta Accreta and Normotensive Placentas in the 3rd Trimester of Pregnancy

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dc.contributor.authorErdoğan, Gamze
dc.contributor.authorKaya, Seval
dc.contributor.authorPeker, Nurullah
dc.contributor.authorİbiloğlu, İbrahim
dc.contributor.authorDeveci, Engin
dc.date.accessioned2025-02-22T14:13:32Z
dc.date.available2025-02-22T14:13:32Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: We aimed to immunohistochemically examine the expression level of Placental growth factor (PLGF) and Soluble FMS-like tyrosine kinase-1 (sFlt-1) proteins in normotensive, Placenta accreta (PA) and Placenta previa (PP). Materials and Methods: Three groups were created for the study: 20 Nomotensive placentas, 20 PP and 20 PA from women diagnosed with placenta samples. 4-6 μm thick sections were taken from the placentas, PLGF and sFlt-1 immunostaining were applied to the obtained sections, and their expression intensities and localizations in the tissues were determined. Results: As a result of our observations, normotensive placenta group; sFlt-1 expression was observed in hofbauer cells and syncytial nodes and PLGF positive expression was observed in nuclei of muscle cells in some tunica media region. PP and PA group; sFlt-1 expression was positive in decidua cells, hofbauer cells and dilated vascular endothelium. PP and PA group; negative PLGF expression was observed in syncytial nodes and positive PLGF expression was observed in hofbauer cells and endothelial cells. There was a significant difference between normotensive, PP and PA groups (p<0.05). Conclusions: It can be thought that sFlt-1 and PLGF may be important signal stimulators and markers in the trophoblastic degeneration, apoptotic cells, increase in angiogenesis and imbalance in implanta-tion seen in cases of PP and PA.en_US
dc.identifier.doi10.35440/hutfd.1487194
dc.identifier.endpage414en_US
dc.identifier.issn1304-9623
dc.identifier.issn1309-4025
dc.identifier.issue3en_US
dc.identifier.startpage407en_US
dc.identifier.trdizinid1289399en_US
dc.identifier.urihttps://doi.org/10.35440/hutfd.1487194
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1289399
dc.identifier.urihttps://hdl.handle.net/11468/30054
dc.identifier.volume21en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofHarran Üniversitesi Tıp Fakültesi Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_TR_20250222
dc.subjectSFlt-1en_US
dc.subjectPlacenta previaen_US
dc.subjectPlacenta accretaen_US
dc.subjectPLGFen_US
dc.titleInvestigation of PLGF, sFlt-1 Expression in Placenta Previa, Placenta Accreta and Normotensive Placentas in the 3rd Trimester of Pregnancyen_US
dc.typeArticleen_US

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