Vimentin and Tumor Necrosis Factor-? Expression in Peripheral Nerves in Experimental Diabetic Neuropathy

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dc.contributor.authorBaloglu, Murat
dc.contributor.authorCetin, Abdurrahman
dc.contributor.authorTuncer, Mehmet Cudi
dc.date.accessioned2024-04-24T17:47:36Z
dc.date.available2024-04-24T17:47:36Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the role of intermediate filaments and cytokines in peripheral nerve injury in experimentally induced diabetic rats. STUDY DESIGN: Male Sprague-Dawley rats were administered streptozotocin (STZ) 55 mg/kg/day intraperitoneally to induce type 1 diabetes mellitus. At 2 days post-administration, the caloric intake from the tail vein was 250 mg/dL and the rats were considered to be diabetic. The diabetic and control groups were compared in terms of glucose values. Sciatic nerve specimens were taken for basic histology, immunohistochemistry, and western blot analyses. RESULTS: The blood glucose concentration in the diabetic rats was significantly increased (p <0.001). Histopathological examination of the diabetic group showed axonal degeneration with thinning in myelinated fibers, hypertrophy in Schwann cells, dilation in small blood vessels, and mononuclear cell infiltration in connective tissue areas. CONCLUSION: There was a deterioration in the myelination mechanism as a result of the influence of the intermediate filaments. The peripheral nerve caused the rapid development of axonal atrophy, resulting in the loss of nerve cells due to increased necrotic formation with cellular infiltration.en_US
dc.identifier.endpage238en_US
dc.identifier.issn0884-6812
dc.identifier.issue5en_US
dc.identifier.startpage231en_US
dc.identifier.urihttps://hdl.handle.net/11468/22628
dc.identifier.volume40en_US
dc.identifier.wosWOS:000448394500003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectDiabetic Footen_US
dc.subjectDiabetic Neuropathiesen_US
dc.subjectDiabetic Neuropathyen_US
dc.subjectPainfulen_US
dc.subjectDiabetic Peripheral Neuropathyen_US
dc.subjectNeuropathyen_US
dc.subjectRatsen_US
dc.subjectLaboratoryen_US
dc.subjectRatsen_US
dc.subjectSprague-Dawleyen_US
dc.subjectTnf-Alphaen_US
dc.subjectTumor Necrosis Factoren_US
dc.subjectTumor Necrosis Factor-Alphaen_US
dc.subjectVimentinen_US
dc.titleVimentin and Tumor Necrosis Factor-? Expression in Peripheral Nerves in Experimental Diabetic Neuropathyen_US
dc.titleVimentin and Tumor Necrosis Factor-? Expression in Peripheral Nerves in Experimental Diabetic Neuropathy
dc.typeArticleen_US

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