Effects of Malathion in Fetal Kidney Tissues in Pregnant Rats: Teratogenic Effects Induced by Different Doses

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dc.contributor.authorAlp, Harun
dc.contributor.authorSak, Muhammet Erdal
dc.contributor.authorEvsen, Mehmet Siddik
dc.contributor.authorFirat, Ugur
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorPenbegül, Necmettin
dc.contributor.authorSancaktutar, Ahmet Ali
dc.date.accessioned2024-04-24T17:48:01Z
dc.date.available2024-04-24T17:48:01Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of this study was to investigate the teratogenic effects of Malathion (ML) induced by different doses on fetal kidney tissues in pregnant rats. A total of 28 Sprague-Dawley pregnant rats were randomly divided into 4 groups of 7 rats each. Depending on ML dose, four groups were formed, including (I) control, (II) ML 2.5 (ML 2.5 mg/kg/day, orally), (III) ML 5 (5 mg/kg/day, orally), and (IV) ML 10 (10 mg/kg/day, orally). ML application started when the male and female were put together (when mating started). Daily ML application was continued until birth. It was determined that in parallel with dose of ML, ML resulted in toxic effects on serum enzymes (acetyl-cholinesterase (AChE), amylase and lipase) and kidney tissues of pregnant rats, and also -regardless of ML dose in fetal kidneys-it led to teratogenic effects in all the doses. Biochemical data wasconfirmed by histopathologic data. We concluded that ML leads to kidney damage in both pregnant and fetal rats as a result of its teratogenic and toxic effects.en_US
dc.identifier.endpage226en_US
dc.identifier.issn1300-6045
dc.identifier.issue2en_US
dc.identifier.startpage221en_US
dc.identifier.urihttps://hdl.handle.net/11468/22854
dc.identifier.volume18en_US
dc.identifier.wosWOS:000302198700009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisien_US
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFetusen_US
dc.subjectPregnant Raten_US
dc.subjectOrganophosphateen_US
dc.subjectPrenatal Exposureen_US
dc.subjectTeratogenic Effecten_US
dc.titleEffects of Malathion in Fetal Kidney Tissues in Pregnant Rats: Teratogenic Effects Induced by Different Dosesen_US
dc.titleEffects of Malathion in Fetal Kidney Tissues in Pregnant Rats: Teratogenic Effects Induced by Different Doses
dc.typeArticleen_US

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