Ascitic fluid lymphocyte subgroups and cytokine levels in patients with spontaneous bacterial peritonitis
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Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: Spontaneous bacterial peritonitis (SBP) is a serious complication of liver cirrhosis and has a high mortality rate. Immune system plays a part in all steps of this infection increase. Insufficient serum complement activity in ascitic fluid, reticuloendothelial system dysfunction, all of the insufficient opsonic activity seem related to spontaneous bacterial peritonitis increase. The aim of our study is to investigate the effects of some cytokines and lymphocyte subgroups in ascitic fluid on increase of spontaneous bacterial peritonitis. Methods: The study population consisted of 41 decompensated cirrhotic patients (30 men, 11 women) with different etiologies. Ascitic fluid lymphocyte surface markers (CD3, CD4, CD8, CD16, CD19, CD56) and cytokine levels (IL-6, IL-8, IL-10, TNF-?) were searched in all patients. Results: In culture positive and negative groups, no significant differences were found between CD3, CD4, CD8, CD16, CD19, CD56 with CD4/CD8 ratio from lymphocyte surface markers worked in ascitic fluid (P > 0.05). There was a significant difference between infected and non -infected groups concerning CD4/CD8 ratio and between CD4 and CD8 values concerning lymphocyte surface markers in ascitic fluid. No significant difference was found in ascitic fluid IL-8 and TNF-? levels between infected and non-infected groups. Conclusion: According to the study, Th1 immune response is predominant to Th2 immune response. It also demonstrates that TNF-? might be involved in the pathogenesis of ascites infections.
Açıklama
Anahtar Kelimeler
Ascidic Fluid Lymphocyte Subgroups, Cytokines, Spontaneous Bacterial Peritonitis
Kaynak
Journal of Chinese Clinical Medicine
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
4
Sayı
9
