Comparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertility

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dc.contributor.authorOğlak S.C.
dc.contributor.authorSakar M.N.
dc.contributor.authorEge S.
dc.contributor.authorOtçu S.M.Ö.
dc.contributor.authorObut M.
dc.contributor.authorKahveci B.
dc.contributor.authorYıldız İ.
dc.date.accessioned2024-04-24T17:58:26Z
dc.date.available2024-04-24T17:58:26Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis study aimed to determine the outcomes of combined treatment of letrozole (LTZ) with recombinant follicle-stimulating hormone (rFSH) in comparison with rFSH alone in intrauterine insemination (IUI) cycles. This study consisted of 86 patients who experienced 106 IUI cycles. Patients were classified into two treatment groups: group I underwent a combination of LTZ plus rFSH, and group II received rFSH alone. Ovulation was tr iggered with human chorionic gonadotropin (hCG), and IUI performed 36 hours later. The number of follicles ?18 mm, endometrial thickness, required dose of FSH, duration of ovulation induction (OI), clinical pregnancy rates, multiple pregnancy rates, spontaneous abortion rates, and live birth rates were evaluated. The total required rFSH dose during the OI was significantly lower in the LTZ-rFSH combination group than the rFSH alone group (401.2±177.1 IU and 770.1±345.8 IU, respectively, p<0.001). The days of stimulation with rFSH were also lower in the LTZ co-treatment group than the rFSH-alone group (5.2±1.3 days and 10.1±3.0 days, respectively, p<0.001). Clinical pregnancy rate was 17.0% in LTZ-rFSH group, and 15.2% in rFSH group (p>0.05). The combined use of LTZ with rFSH resulted in a lower required dose of rFSH, a similar and ac ceptable endometrial thickness at the day of hCG administration, and comparable pregnancy rate compared with rFSH alone. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.en_US
dc.identifier.doi10.5505/ejm.2020.24993
dc.identifier.endpage433en_US
dc.identifier.issn1301-0883
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85089313988
dc.identifier.scopusqualityQ4
dc.identifier.startpage427en_US
dc.identifier.urihttps://doi.org/10.5505/ejm.2020.24993
dc.identifier.urihttps://hdl.handle.net/11468/23918
dc.identifier.volume25en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherYuzuncu Yil Universitesi Tip Fakultesien_US
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGonadotropinen_US
dc.subjectIntrauterine İnseminationen_US
dc.subjectLetrozoleen_US
dc.subjectOvulation İnductionen_US
dc.titleComparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertilityen_US
dc.titleComparison of the efficacy of letrozole and gonadotropin combination versus gonadotropin alone in intrauterine insemination cycles in patients with unexplained infertility
dc.typeArticleen_US

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