Ethyl pyruvate prevents ischemia reperfusion injury in isolated perfused rat heart

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dc.contributor.authorAkkoc H.
dc.contributor.authorTunik S.
dc.contributor.authorKelle I.
dc.contributor.authorGurkan A.
dc.contributor.authorErdogmus Z.
dc.contributor.authorSimsek S.
dc.contributor.authorErdinc M.
dc.date.accessioned2024-04-24T18:45:44Z
dc.date.available2024-04-24T18:45:44Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the present study was to investigate the protective effect of ethyl pyruvate (EP) against ischemia reperfusion (I/R) injury in isolated rat heart. Male Sprague-Dawley rats were divided into three groups (n = 8); Group 1: Control group, Group 2: I/R, Group 3: I/R+EP. Ischemia was produced for 30 min by blocking the perfusion with Krebs Henseleit solution and it was followed by reperfusion for 60 min. In group 3, EP (2 mmol/L) was added into Krebs Henseleit solution after stabilization period. EP did not change the number of ?-smooth muscle actin positive vessels and expression of Bcl-2 and desmin. Treatment with EP significantly reduced I/R induced extension in infarct size (p < 0.001) and release of lactate dehidrogenase (p < 0.001) and creatine phosphokinase (p < 0.05). Myocardial I/R injury significantly increased oxidative stress index and malondialdehyde, total oxidant status levels and significantly decreased paraoxonase actvity and total antioxidant status (p < 0.05). On the other hand, alterations in these biochemical indices due to I/R injury were attenuated by EP treatment (p < 0.01). These results show that ethyl pyruvate prevents ischemia reperfusion injury in isolated perfused rat heart.en_US
dc.identifier.endpage370en_US
dc.identifier.issn0326-2383
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84878688226
dc.identifier.scopusqualityQ4
dc.identifier.startpage364en_US
dc.identifier.urihttps://hdl.handle.net/11468/24845
dc.identifier.volume32en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectEthyl Pyruvateen_US
dc.subjectInfarct Sizeen_US
dc.subjectMyocardial Reperfusion İnjuryen_US
dc.subjectOxidative Stressen_US
dc.titleEthyl pyruvate prevents ischemia reperfusion injury in isolated perfused rat hearten_US
dc.titleEthyl pyruvate prevents ischemia reperfusion injury in isolated perfused rat heart
dc.typeArticleen_US

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