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    Evaluation of the Frequency of QTc Dispersion and Its Relationship with Clinical and Laboratory Parameters in Dialysis Patients
    (Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2013) Yilmaz, Zulfukar; Yildirim, Yasar; Yilmaz Aydin, Fatma; Aydin, Emre; Kadiroglu, Ali Kemal; Yilmaz, Mehmet Emin; Kayabasi, Hasan
    OBJECTIVE: QTc dispersion is defined as the difference between the maximal and minimal correct QT interval on standard 12-lead ECG. Increased QTc dispersion has been reported in ESRD patients. In our study, we aimed to evaluate the frequency of QTc dispersion and its relationship between clinical and laboratory parameters in patients on regular dialysis programme. MATERIAL and METHODS: Sixty patients underwent dialysis ( 30 HD, 30 CAPD) and another 30 healthy subjects were enrolled into the study. The standard 12 lead ECGs were performed and QTcd was measured from all dialysis patients and control subjects. Blood samples were collected for the measurement of laboratory parameters. RESULTS: Dialysis patients showed significantly higher QTcd than control subjects (55.75 +/- 36.48 versus 28.73 +/- 28.27; p=0.001). Patients with QTcd > 50 ms had significantly higher SBP, urea and ferritin levels, but significantly lower iron binding capacity and calcium levels compared those with QTcd <= 50 ms(p<0.05). Positive correlations were found between QTcd and urea, ferritin and SBP levels, and inverse correlations with iron binding capacity level (p<0.05). CONCLUSION: The frequency of QTc dispersion was 40% among the dialysis patients. Although serum calcium was significantly lower in patients who had QTcd > 50 ms than QTcd <= 50 ms (p<0.05), there was no significant correlation between QTcd and calcium.
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    The relationship between acute kidney injury and inflammation-based parameters and mortality in oncologic intensive care patients
    (Turkish Society of Medical and Surgical Intensive Care, 2020) Aydın, Emre E.; Kadiroǧlu, Ali Kemal; Yilmaz Aydin, Fatma; Kara, Ali Veysel
    Background and Aims: Cancer patients are admitted to intensive care units (ICU) due to primary diseases, treatment-related conditions or comorbid diseases. Acute kidney injury (AKI) and infections appear to be factors affecting mortality and morbidity in ICU follow-up. Therefore, in our study, we investigated the effect of AKI and inflammation-based parameters on mortality in cancer patients admitted to the ICU. Materials and Methods: In this study, 386 patients diagnosed with malignancy hospitalized between 2010 and 2014 in Dicle University Medical Faculty Internal Medicine ICU were included. The study was designed retrospectively. The demographic characteristics and clinical information of the patients were obtained from the files. Subsequently, patients were classified as non-survivors (group 1) and survivors (group 2). Both groups were compared in terms of the presence and stage of AKI by KDIGO definition, neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR). Results: Creatinine, CRP, neutrophil counts were found to be significantly higher and albumin, hemoglobin, platelet and lymphocyte counts were found to be lower in group 1 (n=276) compared to group 2 (n=110). Length of ICU was longer in group 2 patients. There was a positive correlation between mortality and KDIGO stages and NLR. Mortality rate was increased 1.9 fold in KDIGO stage 1, 2.3 fold in stage 2, 2.4 fold in stage 3 and 1.5 fold if NLR>5. There was no statistically significant relationship between PLR and mortality. Conclusion: The presence of AKI and elevated inflammation-based parameters were associated with mortality in oncologic patients admitted to the ICU.