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    PREVALENCE OF FACTOR XIII VAL34LEU POLYMORPHISM IN THROMBOSIS CASES IN THE SOUTHEAST OF TURKEY AND ITS CORRELATION WITH THROMBOSIS
    (Carbone Editore, 2017) Yildirim, Mehmet Serdar; Dal, Mehmet Sinan; Karakus, Abdullah; Oto, Ferhat; Goruk, Mucahit; Akdogan, Mehmet Recai; Nas, Necib
    Background: Thrombosis is triggered by a shift in the balance of procoagulant and anticoagulant factors due to acquired or inherited causes. Factor XIII plays an important role in the stabilization of the linkage between fibrins. Three different genetic structure of Valine34Leucine polymorphism in FXIIIA have been described. Valine/Valine structure has been identified as the homozygous normal (wild-type), whereas Valine/Leucine and Leucine/Leucine structures have been identified as heterozygous and homozygous mutants respectively. Genetic polymorphisms in FXIII-A subunit vary substantially from society to society. The primary objective of this study was to determine the relationship between factor XIII polymorphisms and arterial/venous thromboembolism in the southeast of Turkey. Methods: A total of 127 patients with arterial and venous thrombosis were included as the study group and 102 healthy subjects with no thromboembolic disorders were included as the control group. Val34Leu polymorphism in FXIII was investigated in both groups using PCR (Polymerase chain reaction). Results: The prevalence of the polymorphism in the study and control groups were compared with chi-square test, no statistically significant differences were found (the prevalence in the study and control group are 68.5% and 66.7% for V/V allele, 29.2% and 29.4% for V/L allele, and 2.4% and 3.9% in L/L allele respectively, with p = 0.787). When deep vein thrombosis (DVT) diagnosed female patients group (n = 8) was compared to the healthy female control group, V/L allele was significantly lower, whereas L/L allele was significantly higher (p = < 0.01). Conclusions: This study indicates that there is no evidence for association between factor XIII-A Val34Leu polymorphism and arterial/venous thromboembolism. The significant result we found for the DVT patients should be strengthened by further studies with greater number of cases. In future, further studies are needed with more specific groups and with greater numbers of patients.
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    Öğe
    Roles of metabolic tumor volume and total lesion glycolysis on 18F-FDG PET/CT, CA19-9 levels, and complete blood parameters in predicting survival in patients with unresectable or metastatic pancreatic cancer
    (Edizioni Luigi Pozzi, 2022) Erdur, Erkan; Guzel, Yunus; Yildirim, Ozgen Ahmet; Poyraz, Kerem; Yildirim, Mehmet Serdar; Kaplan, Ilsan
    AIM: In this study, we aimed to investigate the roles of volume based F-18-FDG PET/CT parameters, CA19-9 levels, and complete blood count parameters in predicting survival in patients with unresectable and/or metastatic pancreatic ductal adenocarcinoma. MATERIALS AND METHOD: Fifty-seven pancreatic cancer patients who were followed in University of Health Sciences Gazi Yasargil Training and Research Hospital between January 2017 and June 2020, declined surgical treatment and/or radiation therapy or had medically inoperable, unresectable, or metastatic disease, and received chemotherapy were included in the study. F-18-FDG PET/CT images of patients were evaluated and calculated metabolic tumor volume (MTV) and total lesion glycolysis (TLG) parameters were compared with CA19-9 levels and complete blood count parameters. Patients were assessed in two groups as survivors and non-survivors. RESULTS: Total MTV and total TLG on F-18-FDG PET/CT were significantly higher among non-survivors than survivors (p: 0.023 and 0.034, respectively). Multivariate Cox regression analysis revealed that TLG higher than 46 g/ml.cm(3), MTV higher than 11.02 cm(3) (OR 0.987, 95%CI 0.976-0.999, p:0.029 and OR 0.246, 95%CI 0.089-0.685, p: 0.007, respectively) and elevated MPV (OR:0.785, 95% CI 0,574-0.976, p:0.042) were independent prognostic factors for predicting mortality. CONCLUSION: TLG >46 g/ml.cm(3) and MTV >11.02 cm(3) in F-18-FDG PET/CT and elevated MPV in complete blood count are independent prognostic factors for predicting mortality in patients with unresectable or metastatic pancreatic cancer who are treated with chemotherapy.