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Öğe Bir erkek keçide ürolithiazis olgusu(Dicle Üniversitesi Veteriner Fakültesi, 2014) İçen, Hasan; Şimşek, Aynur; Sekin, Servet; Çelik, Özgür Yaşar; Çakmak, Fırat; Yaman, TuranÇalışmanın materyalini 2-3 gündür idrar yapamama, sancı ve iştahsızlık şikayeti ile Dicle Üniversitesi Veteriner Fakültesi İç Hastalıkları Kliniği’ne getirilen 1,5-2 yaşlı bir erkek keçi oluşturdu. Hastanın klinik muayenesinde ayakta durmakta güçlük, abdominal gerginlik, anal bölge ile prepisyum çevresinde ödem, prepisyumun uç kısmında kuruluk ve küçük taşlar saptandı. Nabız frekansı 119/dk, solunum frekansı 32/dk ve vücut ısı 36.9 °C olarak tespit edilen hayvana, kan ve idrar örneklerinin laboratuar analiz sonuçları ile otopsi bulgularına göre ürolithiazis tanısı konuldu.Öğe Congenital meningoencephalocele in a Brown Swiss calf: A case report(2013) Yaman, Turan; Özyıldız, Zafer; Terzi, Funda; Erdoğan, SerkanDicle Üniversitesi Veteriner Fakültesi Pataloji Anabilim Dalına ölü olarak getirilen 2 günlük montofon ırkı erkek buzağıda inspeksiyon ve radyolojik muayeneler sonucu meningoceleden şüphelenildi. Yapılan patolojik-anatomik incelemeler sonunda, squama frontalis üzerinde 17x15 cm çapında, fluktuan kıvamlı, üzeri kıllı deri ile kaplı bir kese gözlendi. Kese içerisinde yaklaşık 200 mL kanla karışık seröz ve akışkan bir sıvı ile karşılaşıldı. Beyin meninkslerle birlikte frontal kemiğin rostrodorsaline doğru fıtıklaşmıştı. Os ethmoidale rudimenter olarak gelişmişti ve bu yüzden etmoid labirentler bu bölgede saptanamadı. Ayrıca, os nasalenin ve os frontalenin pars nasalis bölümünün olmadığı, nazal konkalar ile sert damağın rostral yarımının bulunmadığı saptandı. Serebral hipoplazi ve makrogyri belirgindi. Sonuç olarak nadir olarak gözlenen meningoencephalocele olgusu, Diyarbakır ilinde ilk defa bir buzağıda anatomopatolojik olarak tanımlandı.Öğe Detection of bovine respiratory syncytial virus, Pasteurella multocida, and Mannheimia haemolytica by immunohistochemical method in naturally-infected cattle(Sciendo, 2018) Yaman, Turan; Büyükbayram, Hüseyin; Özyıldız, Zafer; Terzi, Funda; Uyar, Ahmet; Keleş, Ömer Faruk; Özsoy, Şule Yurdagül; Yener, ZabitIntroduction: The aim of this study was to determine the predisposing effect of bovine respiratory syncytial virus (BRSV) on Pasteurella spp. infection in naturally-induced pneumonia in cattle by immunohistochemical labelling. Material and Methods: Lungs of cattle slaughtered in the slaughterhouse were examined macroscopically, and 100 pneumonic samples were taken. The samples were fixed in 10% neutral formalin and embedded in paraffin by routine methods. Sections 5 μm in thickness were cut. The streptavidin-peroxidase method (ABC) was used to stain the sections for immuno-histochemical examination. Results: BRSV antigens were found in the cytoplasm of epithelial cells of bronchi, bronchioles, and alveoles and within inflammatory cell debris and inflammatory exudate in bronchial lumens. Pasteurella spp. antigens were detected in the cytoplasm of the epithelial cells of bronchi and bronchioles, and in cells in the lumens of bronchi and bronchioles. Eleven cases were positive for only one pathogen (six for BRSV and five for Pasteurella spp.), while 35 cases were positive for 2 pathogens: BRSV plus P. multocida (n = 21) or M. haemolytica (n = 14). Conclusion: The presence of high levels of BRSV in dual infections indicates that BSRV may be the main pneumonia-inducing agent and an important predisposing factor for the formation of Pasteurella spp. infections in cattle naturally afflicted with pneumonia.Öğe Diagnosis of q fever and brucellosis in aborted ovine fetuses by microbiological, pathological and immunohistochemical methods(Walter de Gruyter GmbH, 2018) Yeşilmen, Simten; Yaman, Turan; Sağsöz, Hakan; Bademkıran, ServetBrucellosis and Q fever, two zoonoses, are important causes of abortion in ruminants, as well as economically significant diseases caused by a gram-negative bacterium. Determination of these diseases is therefore of great importance. In this study, the organs of 35 naturally infected and aborted ovine fetuses were examined for the presence of changes resulting from infections by Brucella melitensis and Coxiella burnetii, according to macroscopic, bacteriological, histopathological and immunohistochemical methods. B. melitensis was observed in 21 cases, and C. burnetii was observed in 8 cases of the aborted ovine fetuses, and these were determined with immunohistochemical methods. Brucellosis was observed in 18 of the aborted ovine fetuses, and this was determined by microbiological methods. Negative (-) results were found for all of the other fetuses. The Brucella antigen was determined to be localized as intracytoplasmic in mainly alveolar macrophages, bronchi, bronchioles, glandular epithelial cells around bronchial glands, neutrophils, hepatocytes and Kupffer cells. The Coxiella antigen was found to be localized in the alveolar macrophages in the lungs, bronchi, bronchioles and alveolus, and in the cytoplasms of bronchial gland epithelial cells, and in the cytoplasms of hepatocytes and Kupffer cells in the liver. Immunohistochemical and microbiological diagnoses of brucellosis and coxiellosis were compared; it was concluded that immunohistochemical methods were more safely applied than microbiological methods.Öğe Diaphragmatic hernia in a sheep - a case report(Univ Zagreb Vet Faculty, 2018) Simsek, Aynur; Yaman, Turan; Icen, Hasan; Kochan, AkinA two-year-old sheep was referred to the clinics of the Department of Internal Medicine of Dicle University, Faculty of Veterinary Medicine, with signs of anorexia, abdominal tympany and constipation. The clinical examination of the animal revealed the presence of respiratory failure associated with weaker lung sounds on the right side of the body when compared to the left side. There were no ruminal movements, and when the rumen was probed with a stomach tube, no ruminal content was obtained. The animal was euthanized upon the request of the owner, and a necropsy was performed. At necropsy, it was observed that the left hepatic lobe had protruded into the thoracic cavity through a defect in the diaphragm, and that a diaphragmatic hernia had developed.Öğe Protective effect of intravesical platelet-rich plasma on cyclophosphamide-induced hemorrhagic cystitis(Canadian Soc Clinical Investigation, 2016) Özyuvalı, Ekrem; Yıldırım, Mehmet Erol; Yaman, Turan; Kösem, Bahadır; Atlı, O.; Çimentepe, ErsinPurpose: Hemorrhagic cystitis (HC) is the most common urotoxic side effect of cyclophosphamide (CYP). Platelet rich plasma (PRP) plays an important role in wound healing and inflammatory responses. The aim of this study was to investigate the efficacy of intravesical PRP at treatment of interstitial cystitis (IC). Material-Methods: Female rats (n=24) were used. IC was induced by intraperitoneal injection of cyclophosphamide (CYP). Rats were randomly allocated to one of four groups (n = 6 per group): a control group; a sham group with saline (75 mg/kg; i.p.) instead of CYP on day 1; a IC group, which was injected with CYP (150 mg/kg; i.p.) on day 1; and, a intravesical PRP-treated group which was injected with CYP (150 mg/kg; i.p.) on day 1. On day 2, the rats in each group were sacrificed under anesthesia. Results: Histological evaluation showed that bladder inflammation in CYP-treated rats was not suppressed by PRP. CYP administration induced severe IC with marked edema, hemorrhage and inflammation in CYP and CYP+PRP groups, but PRP was not found to be effective to decrease these effects. Conclusion: The application of PRP could not reverse the histopathological changes in rats that had interstitial cystitis due to the cyclophosphamide injection.Öğe Streptozotosin ile diyabet oluşturulan sıçanlarda meşe palamudu (Quercus branti lindl.) ekstraktların karaciğer ve pankreası koruyucu etkileri(Dicle Üniversitesi Veteriner Fakültesi, 2016) Yaman, Turan; Doğan, AbdulahadDiabetes mellitus (DM) tüm dünyada en sık rastlanan kronik endokrin bozukluktur. Sunulan bu çalışmada, streptozotosin (STZ) ile oluşturulan diyabetik sıçan modelinde, karaciğer ve pankreas yapısında ortaya çıkan histolojik değişiklikler üzerine güçlü antioksidan özelliklere sahip olan meşe palamudu (Quercus branti Lindl.) ekstraktının farklı dozlarının koruyucu etkinliği diyabet tedavisinde kullanılan ticari bir preparasyon olan Akarboz (Glukobay®) ile kıyaslamalı olarak araştırıldı. Kırkiki adet erkek Wistar albino cinsi sıçan; Kontrol; Diabetes mellitus (DM); DM + 20 mg/kg Akarboz; DM + 100 mg/kg meşe palamudu (MP) ekstresi (MP1); DM + 250 mg/kg MP ekstresi (MP2) grubu, DM + 500 mg/kg MP ekstresi (MP3) olmak üzere 6 gruba ayrıldı. Deneysel diyabet 50 mg/kg streptozotosinin intraperitoneal (i.p.) olarak enjeksiyonu ile oluşturuldu. Meşe palamudu ekstraktının tüm dozları ve Akarboz 21 gün boyunca gastrik gavaj yolu ile verildi. Kan glukoz düzeyleri deney süresince kaydedildi. Karaciğer kesitlerinin incelenmesinde, diyabetik sıçanlarda hepatositlerde dejenerasyon ve nekroz, portal alanlarda yangısal hücre infiltrasyonu, fibrozis ve safra kanalı hiperplazisi görüldü. Pankreas kesitlerinde langerhans adacıklarının belirgin hücre kaybı sonucu normal görünümünü kaybettiği gözlendi. Bu histopatolojik değişiklikler meşe palamudu ekstraktı verilen MP1, MP2 ve MP3 gruplarında önemli derecede azalmıştı. Sonuç olarak, meşe palamudu ekstraktının sıçanlarda STZ ile oluşturulan diyabette karaciğer ve pankreas hasarına karşı koruyucu etkiye sahip olduğu sunulan bu çalışma ile ortaya konmuştur.
