Yazar "Yaldiz, Mehmet" seçeneğine göre listele

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    Evaluation of effects of memantine on cerebral ischemia in rats
    (Riyadh Armed Forces Hospital, 2008) Aluclu, Mehmet U.; Arslan, Seyfi; Acar, Abdullah; Guzel, Asian; Bahceci, Selen; Yaldiz, Mehmet
    Objective: To evaluate the effects of memantine on infarct size in cerebral ischemia and on neurological outcome after temporary middle cerebral artery occlusion (MCAO) and reperfusion in rats. Methods: In this study, performed between 2002-2004 in Dicle University School of Medicine, Diyarbakir, Turkey, 30 adult Sprague-Dawley rats were used. Cerebral ischemia was constituted by the intraluminal filament method with a 4-0 nylon suture. Reperfusion was started after 2 hours of MCAO. The rats were randomly divided into 2 groups as control and memantine. Saline 0.9% (0-5 ml/kg) and memantine (30 mg/kg) were administered via nasogastric intubations. Three coronal slices of 2 mm thickness were obtained from cerebrum, cerebellum, and brain stem, and were stained with a 2% solution of triphenyltetrazolium chloride. Transparent sheets were placed over each section and the areas of the brain and infarct were measured. Results: Forty-five slices from each group (total 90) were obtained. Percent of ischemic area (%) in cerebrum, cerebellum, and brain stem level in memantine was lower than those of the control group (p < 0.0001). In addition, we determined an improvement in neurological score at 24th and 72nd hours in the rats that have been given memantine. The memantine group showed significantly better recovery than the control group (p < 0.0001). Conclusions: We concluded that memantine may decrease ischemic area in experimental cerebral ischemia in rats and it seems that memantine may be beneficial in cerebral ischemia.
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    Evaluation of erythroprotein effects on cerebral ischemia in rats
    (Maghira & Maas Publications, 2007) Aluclu, Mehmet Ufuk; Acar, Abdullah; Guzel, Aslan; Bahceci, Selen; Yaldiz, Mehmet
    Objective: Majority of severe disabilities in adults are caused by stroke. The aim of our study is to learn the effects of erythropoietin (EP), on infarct size in cerebral ischemia and to determine neurological behavioral scores and histopathological evaluation. Material & Methods: In this study 30 adult Sprague-Dawney rats were used. Cerebral ischemia was constituted by intraluminal filament method with a 4-0- nylon suture. Reperfusion was started after two hours of middle cerebral artery occlusion. The rats were randomly divided into two groups as follow: control and EPO groups. Saline 0.9% (0.5 ml/kg) and EPO (5000 U/kg) was administered intraperitoneally in the groups. Three coronal slices in two millimeters thickness were obtained from cerebrum, cerebellum and brain stem, and were stained with a 2% solution of triphenyltetrazolium chloride. Transparent sheets were placed over each section and the areas of the brain and infarct were measured. The neurological scores were determined at 24(th), 48(th) and 72(nd) hours after reperfusion. Results: Percent of ischemic area (%) in cerebrum, cerebellum and brain stem level in EPO groups were less than those of control group (p<0.0001). In addition, we determined that EPO group was better than controls of neurologic score and histopatologically after cerebral ischemia. Conclusions: We concluded that EPO may decrease ischemic area in experimental cerebral ischemia in rats and it seems that EPO may be beneficial.
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    Öğe
    Microbiologic and histologic assessment of intentional bacterial contamination of bone grafts
    (W B Saunders Co-Elsevier Inc, 2007) Yaman, Ferhan; Uenlue, Guelten; Atilgan, Serhat; Celik, Yusuf; Oezekinci, Tuncer; Yaldiz, Mehmet
    Purpose: The purpose of this study was to investigate methods of removing pathogenic microorganisms from bone grafts that have been contaminated during surgery. Materials and Methods: Femora were removed from Sprague-Dawley rats and were divided into sections and contaminated in solutions of the bacteria Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Contaminated bone specimens in each group were immersed in various solutions for specified periods so their antibacterial effects could be evaluated. After these procedures were performed, bone specimens were cultured in nutrient media. Bone structure was evaluated, and the appropriate decontamination method was selected. Results: Solutions such as povidone-iodine, neomycin, cephazolin sodium, and rifamycin were found to be effective decontaminants. These solutions did not damage the bone structure. Among these solutions, only rifamycin was effective against all bacteria used in this study to contaminate bone grafts. Conclusions: Rifamycin seems to be the most suitable agent for the elimination of contamination introduced into bone grafts during surgery. (c) 2007 American Association of Oral and Maxillofacial Surgeons.