Yazar "Yalcin K." seçeneğine göre listele

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    HCV genotypes in HCV related chronic hepatitis in southeast anatolia
    (1999) Yalcin K.; Degertekin H.; Akkiz H.
    The relationship of HCV genotypes with the clinical course and prognosis, and their influence on response to interferon therapy is an important aspect of management of HCV related chronic liver disease. In this study, HCV genotypes were examined for the first time in our region. Serum samples of 50 chronic liver disease patients with HCV antibody positivitiy were analyzed. The male to female ratio was 35/15 with a mean age of 38.13 years (female) and 41 years (male). Hepatitis C virus genotypes were examined by means of Okamoto's mixing method which is based on type specific primers. Of the 50 patients, 28 were positive for HCV RNA and 22 were negative by polymerase chain reaction. We determined genotype 1b in all 28 patients who were positive for HCV RNA. There were no differences between HCV RNA's positive and negative patients in respect to age, gender, history and other findings. Our results are in correlation with those of other studies made in different regions of Turkey. According to these results, HCV genotype 1b is the predominant genotype in patients with HCV related disease in Turkey, including the Southeast region. The results of our study contribute important information to the management and treatment of HCV related chronic liver disease in our country.
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    Öğe
    Horizontal transmission of HBV among students in the Southeastern Anatolia
    (2000) Degertekin H.; Tuzcu A.; Yalcin K.
    Background/aim: In this study, the HBsAg Carrier State and horizontal transmission were investigated among primary and high school students in Diyarbakir, where HBsAg positivity is remarkably high. All results were compared with those of similar studies conducted previously in the same schools. Methods: Overall, 150 students from primary school first grade, 150 students from fifth grade, 200 students from eleventh grade and 200 adults were studied. In all cases HBsAg and anti-HBs were screened by ELISA. Results: HBsAg positivity was 2.7%, 6.1% and 6.2% in the first, fifth and eleventh grade students respectively, while anti-HBsAg positivity was 14%, 20% and 21% in these groups. In adults, HBsAg positivity was 10% and anti-HBsAg 49%. Our results were similar to those of a prior study performed in the same school eight years previously (p>0.05). When both the results from the present study and those from the previous one were evaluated, the difference between the first and fifth grade students was found to be significant (2.1% vs. 6.1% and p<0.05) but that between the fifth and eleventh grades was not (6.2%, p>0.05). This trend also applied to HBsAg positivity. Conclusion: It is concluded that in Diyarbakir and probably in Turkey generally the 7-11 year-old period seems to be the most critical age in the horizontal transmission of HBV infection. During high school years, this risk lessens. In addition to HBV vaccination at birth, it would therefore be appropriate to vaccinate first grade students at the age of seven for the next 7-8 years.
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    Öğe
    Seroepidemiology of delta hepatitis in Turkey
    (1999) Degertekin H.; Yukselen A.V.; Dursun M.; Yalcin K.
    Hepatitis Delta Virusu (HDV) infection is an important viral disease and its relationship with HBV and related liver disease is well known. This study investigated the role of HDV infection in acute viral hepatitis, HBsAg carriers and chronic liver disease cases in Turkey. The results of studies undertaken during the last decade were also evaluated. According to these studies, anti-HDV positivity is about 10% in western of Turkey whilst it is higher in the middle and eastern regions and 15-25% in the south-east in viral hepatitis cases. Delta co and superinfections are of equal prevalence in the southeastern region. Anti-HDV positivity is about 4% in HBsAg carriers in our country and the role of HDV infection in chronic liver disease is of great interest. Anti-HDV positivity varies from 20% to 50% in such cases with the highest prevalence in the south-east. However, the high seropositivity of HDV infection has been decreasing in recent years. To conclude, HDV infection remains a serious disease in Turkey, and should be considered in both acute and chronic liver disease. The significantly high rate of HDV infection in a number of liver diseases in south eastern Turkey is of great interest and appears similar to that of some other Mediterranean Countries, some Mediterranien Countries.