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    The impact of metabolic syndrome on carotid intima media thickness
    (Verduci Publisher, 2013) Aydin, M.; Bulur, S.; Alemdar, R.; Yalcin, S.; Turker, Y.; Basar, C.; Aslantas, Y.
    OBJECTIVES: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities involving several cardiovascular risk factors. Carotid intima media thickness (CIMT) is an important early screening tool to assess subclinical manifestation of cardiovascular and metabolic diseases. We aimed to investigate the impact of MetS on CIMT in a large scaled community based study. METHODS: The study was conducted on 2102 participants. Carotid intima media thickness was measured in all of the participants. The study sample was divided into 4 groups; Group 1 subjects with a body mass index (BMI) < 25.0 kg/m(2) [n = 499 (MetS- = 488, MetS+ = 11)], Group 2 BMI between 25.0 and 29.9 kg/m(2) [n = 693 (MetS-= 559, MetS+ = 134)], Group 3 BMI between >= 30 kg/m(2) and 39.9 kg/m(2) [n = 822 (MetS-= 375, MetS+ = 477)], and Group 4 BMI >= 40 kg/m(2) [n = 88 (MetS-= 27, MetS+ = 61)]. RESULTS: Carotid intima media thickness was higher in the individuals with MetS compared to their normal counterparts. Furthermore, the sub-group analysis showed that CIMT values in Group 1 (0.55 +/- 0.18 vs 0.82 +/- 0.70; p < 0.001), Group 2 (0.59 +/- 0.20 vs 0.68 +/- 0.18; p < 0.001) and Group 3 (0.61 +/- 0.15 vs 0.65 +/- 0.18; p < 0.001) were significantly higher in subjects with MetS compared to their normal counterparts, whereas the values were similar in Group 4 (0.62 +/- 0.13 vs 0.65 +/- 0.17; p = 0.363). CONCLUSIONS: Carotid intima media thickness of overweight, obese and normal weight individuals without MetS were lower than their counterparts with MetS. MetS had no impact on CIMT in morbid obese individuals possibly due to established insulin resistance earlier than MetS.
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    Öğe
    Opinions of the Turkish population on cancer and being informed for the diagnosis of cancer: An opinion survey
    (Amer Soc Clinical Oncology, 2007) Yalcin, B.; Yalcin, S.; Buyukcelik, A.; Sencan, O.; Dogan, M.; Turk, M.; Ozdemir, F.
    [Abstract Not Available]
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    Öğe
    Oxidative stress parameters and ceruloplasmin levels in patients with severe preeclampsia
    (Soc Editrice Univ, 2013) Demir, M. E.; Ulas, T.; Dal, M. S.; Eren, M. A.; Aydogan, H.; Yalcin, S.; Camuzcuoglu, A.
    Background. Oxidative stress is believed to have a role in the development of preeclampsia (PE). It is known that an increased ceruloplasmin (CP) level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and CP levels in patients with severe PE. Patients and Methods. Sixty patients with severe PE and 60 healthy pregnant women were recruited to the study. All study subjects were divided into 2 groups; group 1(n=60) consisted of patients with severe PE, and group 2 (n=60) consisted of healthy pregnant subjects. Blood samples were obtained to measure CP, total antioxidant status and total oxidant status from all subjects. Oxidative stress index was calculated. Results. Compared to group 2; group 1 had significantly higher CP, total oxidant status, oxidative stress index and lower total antioxidant status levels (p<0.001, p<0.001, p=0.001, p=0.008, respectively). Serum CP levels were significantly correlated with oxidative stress index levels (r=0.385, p=0.002). Conclusion. The present study demonstrated that both oxidative stress and CP levels increased in patients with PE, and increased CP levels seem to be a consequence of oxidative stress.