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Öğe Castleman's disease in the porta hepatis(Springer-Verlag, 2000) Uzunlar, AK; Özates, M; Yaldiz, M; Büyükbayram, H; Özaydin, MWe report the CT, ultrasonographic, and pathologic features of a localized forms of Castleman's disease in the porta hepatis due to their unusual location. Our report suggests that the CT and the ultrasonographic features of Castleman's disease in these locations without calcifications is nonspecific.Öğe Cavernous hemangioma of the uterus (A case report)(I R O G Canada, Inc, 2002) Uzunlar, AK; Yilmaz, F; Kilinç, N; Arslan, ACavernous hemangioma of the uterus is an extremely rare lesion. We report a postmenopausal patient with abnormal uterine bleeding due to hemangioma and simple endometrial hyperplasia.Öğe Clenched fist syndrome with palmar lichen planus(Wiley, 2005) Aytekin, S; Turhanoglu, AD; Ozkan, M; Uzunlar, AKA 16-year-old girl had a 4-year history of hyperkeratosis and fissures on the palm. The skin lesions had gradually progressed to thick hyperkeratosis with mild pruritus, diffusely covering the right palm, and leading to flexion contractures of the fingers with mild pain. There was no family history of similar lesions. Her father had died 4 years previously. Dermatologic examination revealed hyperkeratosis, scaling, a mild yellow color, fissures, and maceration on the palm and volar surface of the fingers of the right hand ( Fig. 1). There was an approximately 3 cm x 4 cm hyperkeratotic lesion on the palm of the left hand. Flexion contractures were found at the metacarpophalangeal and proximal interphalangeal joints of the three fingers of the right hand ( Fig. 1). There was no pain, tenderness in the joints of the fingers, or palpable nodular lesions on the palmar surface of the hand. Forced extension was difficult, and there was pain with passive extension. Radiography of the patient's hands revealed no abnormality, other than the clenched fingers. Electromyography of the upper extremities was normal. There were no lesions of the oral mucosa. The nails and scalp were normal. The patient showed very poor eye contact, and responded tersely and somewhat reluctantly to questions about her medical history. The patient was evaluated by psychiatry, but did not meet the diagnostic criteria for any mental disorder. There was a schizoid personality characteristic on both the structured clinical interview for DSM-IV personality disorders (SCID-II) and the Minnesota Multiphasic Personality Inventory ( MMPI). In addition, there was an increase in scores on the hostility and resentment/ aggression subscales of the MMPI. The results of routine laboratory tests were within normal limits or negative, including the venereal disease research laboratory ( VDRL) test. A skin biopsy specimen showed histopathologic changes of lichen planus ( orthokeratotic hyperkeratosis, focal hypergranulosis, acanthosis, papillomatosis, and vacuolization with dense lymphocytic reaction at the dermo- epidermal junction) ( Fig. 2). The patient was treated with topical 5% salicylic acid and 0.1% methylprednisolone aceponate ointment. Static splinting plus stretching was used for hand therapy. Active assisted motion was employed. The treatment produced a remarkable reduction in the skin lesions ( Fig. 3), but no improvement in the flexion posture of the hand. The psychiatric and clinical findings were thought to be consistent with clenched fist syndrome and lichen planus.Öğe Ectopic thyroid tissue in the uterus(Blackwell Munksgaard, 2005) Yilmaz, F; Uzunlar, AK; Sögütçu, N[Abstract Not Available]Öğe Effects of melatonin administration on intestinal adaptive response after massive bowel resection in rats(Springer, 2006) Ozturk, H; Öztürk, H; Yagmur, Y; Uzunlar, AKThis study evaluates whether melatonin can improve the structure of the small intestine and enhance adaptation in an experimental model of short bowel syndrome. Thirty Sprague-Dawley rats were divided randomly into three experimental groups of 10 animals each. In one group, only laparotomy was performed and these rats served as the sham-control group (G 1). The remaining 20 rats under-went 90% small bowel resection (SBR) and formed the two experimental groups: the SBR/untreated group (G2), and the SBR/melatonin-treated group (G3). Rats in the SBR/untreated group received no therapeutic treatment. Rats in the SBR/melatonin-treated group received melatonin intraperitoneally for 3 weeks. The animals were weighed daily. All rats underwent relaparotomy on day 21 of the experiment. Remnant small bowel was excised and evaluated for villus height. total mucosal thickness, and crypt cell mitosis. After the 90% SBR, all animals suffered from diarrhea and weight loss between the first and the sixth postoperative days. The body weight of the SBR/melatonin group showed significant increases at the beginning of postoperative day 10 and day 21 in comparison to that of the SBR/untreated group. The rats treated with melatonin had significantly greater villus height and crypt cell mitosis compared to the sham-control group and the SBR/untreated group. In addition, the mucosal thickness was significantly increased in the SBR/melatonin-treated group compared to the SBR/untreated rats. These observations suggest that melatonin treatment increases villus height, total mucosal thickness, and crypt cell mitosis after massive SBR and it may exert a considerable effect oil the mucosal adaptive response in short bowel syndrome in rats.Öğe Expression of cathepsin D in colorectal adenocarcinomas: Correlation with clinicopathologic features(K Faisal Spec Hosp Res Centre, 2003) Yilmaz, F; Uzunlar, AK; Kilinc, N; Yilmaz, G[Abstract Not Available]Öğe Expression of p53 oncoprotein and bcl-2 in renal cell carcinoma(Saudi Med J, 2005) Uzunlar, AK; Sahin, H; Yilmaz, F; Ozekinci, SObjective: The aim of the present study was to investigate the significance of p53 and bcl-2 as prognostic factors among others in renal cell carcinoma patients. Methods: We evaluated the stages, histological grades, tumor diameters, cellular patterns and the presence of mutant p53 protein and bcl-2 overexpression in 57 cases of renal cell carcinoma (RCC). Kaplan-Meier and log-rank tests estimated the survival function of each parameter. The study was carried out in the Department of Pathology and the Department of Urology, Faculty of Medicine, Dicle University Hospital, Diyarbakir, Turkey, in 2003. Results: The p53 mutation was 35% and bcl-2 overexpression incidence was 89.4% in the RCC cases included in the study. The 5-year disease specific survival rates of mutant p53 positive was 46.6% and p53 negative cases were 83.3%, (p=0.0063). There was no pathological parameter associated in bcl-2, and it has no prognostic significance. Conclusion: The tumor stage, grade, diameter and p53 mutations affect the survival of RCC cases. The bcl-2 staining did not play any role to estimate patients at high risk of the disease progression.Öğe Expressions of p53, proliferating cell nuclear antigen, and Ki-67 in gestational trophoblastic diseases(I R O G Canada, Inc, 2002) Uzunlar, AK; Yilmaz, F; Bayhan, G; Akkus, ZObjective: This study was done to determine whether the expressions of p53, PCNA. and Ki-67 could differentiate spontaneous abortions with hydropic changes from gestational trophoblastic diseases. Materials and Methods: Twenty partial hydatidiforin moles, 21 complete hydatidiform moles. nine invasive hydatidiform moles. three choriocarcinomas and 19 first trimester hydropic spontaneous abortions were evaluated by means of immunohistochemical methods with antibodies to p53, PCNA. and Ki-67 in this study. Results: The Ki-67, PCNA, and p53 immunoreactivity was significantly higher in the gestational trophoblastic disease group than in the spontaneous abortion group with hydropic changes. None of the three parameters provided reliable discrimination among gestational trophoblastic disease subgroups. Conclusion: Our findings Suggest that expressions of Ki-67, proliferating cell nuclear antigen and p53 can be used to differentiate between spontaneous abortion with hydropic changes and gestational trophoblastic disease when all three markers are used together.Öğe Hodgkin's disease and association with Epstein-Barr virus in children in Southeast Turkey(Saudi Med J, 2005) Yilmaz, F; Uzunlar, AK; Sogutcu, N; Ozaydin, MObjectives: There are relatively few reports on histologic and immunophenotypic features of Hodgkin's disease (HD) in children in Turkey. The aim of the present study is to characterize the clinicopathologic, immunophenotypic features and Ebstein-Barr virus (EBV) status of HD in children in our region. Methods: Fifty-two cases coded as HD in the Department of Pathology, Medical Faculty, Dicle University, Turkey, from 1990 to 2002 were retrieved. We analyzed clinicopathologic data, immunophenotype, and EBV status of all patients. Results: In most cases, the cervical lymph nodes were involved. The 52 cases (35 boys, 17 girls; male to female ratio was 2.1) were categorized as mixed cellularity (MC) in 23 (44.2%), lymphocyte predominance (LP) in 16 (30.8%), nodular sclerosis (NS) in 10 (19.2%), and lymphocyte depletion (LD) in 3 (5.8%). Of 33 cases, including MC and NS, Hodgkin's Reed-Sternberg cells and variants were positive for CD15 in 27 cases (81.8%) and positive for CD30 in 30 cases (90.9%). All the cases of LP demonstrated the characteristic phenotype of this variant (CD45RB+, CD20+, CD15-, CD30-). Epithelial membrane antigen stained the lymphocytic/histiocytic cells in 3 cases (18.7%) of 16. Ebstein-Barr virus-LMP1 were positive in 31 cases (61.5%) of a total of 52 cases and the most were MC (91.3%). Conclusion: In conclusion, mixed cellularity HD is the most common histologic subtype. This result differed from that reported in developed countries. We found a striking association with expression of EBV-latent membrane protein 1 in malignant cells in childhood HD.Öğe Malignant ovarian germ cell tumors(I R O G Canada, Inc, 2003) Yilmaz, F; Gül, T; Uzunlar, AKObjective: In this study, some clinicopathologic characteristics and the outcome of patients with malignant ovarian germ cell tumors (MOGCT) were evaluated. Materials and Methods: The clinical charts and pathologic reports of 32 patients with MOGCT treated at the Department of Obstetrics and Gynecology, and diagnosed at the Department of Pathology, Medical Faculty of Dicle University, Turkey from 1983 to 1999 were reviewed. Results: Thirteen patients (40.6%) had dysgerminoma, nine (28.1%) had immature teratoma (four grade 1, three grade 2, and two grade 3), eight (25%) had endodermal sinus tumor, and two (6.3%) patients had mixed germ cell tumors. Site of involvement was unilateral in 30 (19 on the right and 11 on the left) and bilateral in two. All patients underwent primary surgery and 26 patients combination chemotherapy. There seemed to be a relationship between pathologic findings and clinical outcome, and MOGCT histologic types may affect the prognosis. Conclusion: Dysgerminoma had a better prognosis than the nondysgerminomatous group (p < 0.05). This study provides additional data in confirmation of previous reports that management of MOGCT with fertility preservation is safe.Öğe Mucinous tumors of the ovary(I R O G Canada, Inc, 2001) Yaldiz, M; Uzunlar, AK; Kilinç, N; Yalinkaya, A; Akkus, M; Tunik, SOvarian mucinous tumors stem from ovarian surface epithelium and are divided into benign, borderline and malignant. If is difficult to differentiate borderline and malignant mucinous tumors. Thirty-eight cases of ovarian mucinous tumors which were diagnosed at the Pathology Department of Dicle University Medical Faculty were reviewed. Of these, 18 (47.3%), six (15.7%) and 14 (36.8%) were benign, borderline and malignant. respectively. The patients' ages ranged from 18 to 67 (average 44.5) years. Bilaterality was detected in 1/18 (5.5%). 0/6 and 4/14 (28.5%) of benign, borderline and malignant mucinous tumors, respectively. Mean tumor size was 26.4 cm. Microscopically, there was no stratification in the benign tumors. The borderline tumors had papillary infoldings and 2-3 layers of atypical epithelial cells but no invasion of the stroma. Malignant tumors had four or more layers of atypical epithelial cells and stromal invasion.Öğe Naevoid hyperkeratosis of the nipple and areola(European Acad Dermatology & Venereology, 2003) Aytekin, S; Tarlan, N; Alp, S; Uzunlar, AK[Abstract Not Available]Öğe Non-squamous papilloma of the bronchus(Med Assoc S Africa, 2000) Sari, I; Uzunlar, AK; Büyükbayram, H; Ozçelik, C; Yilmaz, F; Özaydin, M[Abstract Not Available]Öğe Protruding urethral leiomyoma obscuring vaginal introitus(East African Medical Journal, 1999) Uzunlar, AK; Özdemir, E; Yilmaz, F; Yaldiz, M; Özaydin, M; Arslan, ALeiomyoma is quite rare in the female urethra. We report an additional case to 29 reported in the literature. A multiparous woman presented with a complaint of a gradually enlarging mass causing dyspareunia for the last seven months. The mass was originating from the upper part of the distal urethra with a relatively thin stalk covered by squamous epithelia, and immunohistopathological examination confirmed it as leiomyoma.Öğe Recurrent malignant schwannoma of the small bowel(Springer-Verlag Wien, 2004) Yilmaz, F; Uzunlar, AK; Bükte, YPrimary malignant schwannoma of the small bowel is an extremely rare disease. Only 24 malignant schwannomas of the small bowel have been reported in the medical English literature. We report a primary malignant schwannoma of the distal ileum in a 53-year old woman, who was admitted to the hospital because of abdominal pain. CT scan revealed a semisolid mass in the small intestine of the serosa. The tumour measuring 14 x 13 x 8 cm and 100 cm of the distal ileum were resected. We observed a recurrence after seventeen months and the recurrent tumour measured 6 x 2.5 x 1 cm was excised.Öğe Survival and reproductive function after treatment of immature ovarian teratoma(I R O G Canada, Inc, 2001) Uzunlar, AK; Yalinkaya, A; Yaldiz, M; Kilinç, N; Gül, TWe conducted a clinical and pathologic review of nine patients with immature ovarian teratoma. The histologic grade of the tumor seemed to be a reliable indicator of prognosis. Low stage and low grade immature ovarian teratomas have an excellent prognosis. Platinum-based chemotherapy has been confirmed to be effective in the management of patients with ovarian germ cell tumors. Low grade pure ovarian immature teratoma is a potentially curable disease and a fertility-sparing surgical approach is possible,Öğe Tuberculosis in an intramammary lymph node(Scandinavian University Press, 2000) Yilmaz, F; Yagmur, Y; Uzunlar, AK[Abstract Not Available]
