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    Öğe
    Immunological Parameters in Migraine Patients
    (Ortadogu Ad Pres & Publ Co, 2009) Tasdemir, Nebahat; Ulug, Nuray Can; Dogan, Bahar Burtan
    Objective: In this study, we aimed to investigate by measuring differences between the levels of plasma cytokines interleukin-1 beta (IL-1 beta), IL-2 receptor, IL-6, IL-8, IL-10, turnout necrotizing factor alpha (TNF-alpha), compleman 3 (Q) and 4 (C4); immunoglobulins G (IgG), IgA, IgM, IgE during migraine attacks and headache-free periods. Material and Methods: Seventy-two patients and 41 age and sex matched healthy people were enrolled in the study. The diagnosis was made according to the International Classification of Headache Disorders (ICHD-II) criteria. Thirty patients out of 72 were in a migraine status while 42 were headache-free. The plasma levels of the cytokines such as IL-10, IL-2 receptor, IL-6, IL-8, IL-10, TNF-alpha, complements (C3, C4) and immunoglobulins were measured in all patients and the controls. Results: The level of TNF-alpha was higher during the attack and the headache-free period in migraine patients than in the healthy control group. The level of C3 was higher during a headache-free period than in the healthy control group. There were significant differences between groups regarding IL-1 beta, IL-6, IL-10 and IgG levels. Conclusion: Immunologic alterations and activity of proinflammatory markers were present during the migraine attack and headache free period in migraine patients.
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    Öğe
    Stevens-johnson syndrome caused by combined use of lamotrigine and fluoxetine and review of the literature
    (Versita, 2010) Ulug, Mehmet; Ulug, Nuray Can; Celen, Mustafa Kemal; Geyik, Mehmet Faruk; Ayaz, Celal
    Stevens-Johnson syndrome (SJS) is a rare, life-threatening acute allergic drug reaction presenting with target lesions and blebs of epidermis. Although a variety of etiologies such as infections and underlying malignancies have been implicated as potential causes of SJS, drugs remain the predominant inciting agent. This report presents a SJS case due to combined use of lamotrigine and fluoxetine. A 41-year-old man was admitted to our clinic with fever, skin eruptions (especially on the face and trunk) and lesions around the mouth. The patient's history revealed lamotrigine and fluoxetine use during the previous three weeks for major depression. Dermatological examination revealed a typical clinical picture of SJS; his psychotropic medications were all stopped. While topical and ocular prednisolone (1mg/kg/day) cares were initiated, steroid dosage was reduced within 15 days. The condition of patient rapidly improved through this treatment. Effective management of SJS begins with prompt recognition of the entity, combined with attention to each of the major organs that may be affected, potential comorbidities and withdrawal of all potentially causative drugs. Clinicians should bear in mind the possibility that drugs with potential risk in developing SJS must be used carefully.