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Öğe ASSESSMENT OF THE UNDERLYING CAUSES OF IMMUNE THROMBOCYTOPENIA: TEN YEARS EXPERIENCE(Pergamon-Elsevier Science Ltd, 2016) Dal, M.; Karakus, A.; Dal, T.; Aydin, B.; Hattapoglu, E.; Ekmen, M.; Ulas, T.[Abstract Not Available]Öğe The effect of day and night shifts on oxidative stress and anxiety symptoms of the nurses(Verduci Publisher, 2012) Ulas, T.; Buyukhatipoglu, H.; Kirhan, I.; Dal, M. S.; Eren, M. A.; Hazar, A.; Demir, M. E.Background: Oxidative stress is believed to have a role in the development of chronic diseases. It is also known that long-term night and shift work in nurses might be associated with many health-related problems like fatigue, sleep problems, anxiety and difficulties in maintaining regular lifestyles. Aim: In this study, we aimed to evaluate the changes of oxidative stress parameters and anxiety indexes of the nurses on day and night shifts. Materials and Methods: One hundred and twenty nurses in ordinary service and intensive care unit (ICU) were enrolled to the study. Subjects were divided into 2 groups; group 1 (n=60) consisted of nurses working in a day shift and group 2 (n=60) as working in the night shift. Further, both groups were divided in to 2 groups again; group la and 2a (both n=30) who working in the ICU, group 1b and 2b (both n=30) in the ordinary service. Just before and the end of the shifts, blood samples were obtained to measure total antioxidant status (TAS) and total oxidant status (TOS). Oxidative stress index (OSI) was calculated. Anxiety index were determined at the end of the shift using State-Trait Anxiety Inventory index. Results: Oxidative stress parameters were increased in all nurses at the end of the day and night shifts (p < 0.05). However, both in service and ICU nurses TAS, TOS, and OSI levels were not significantly different at the beginning and the end of the shifts (p > 0.05). Anxiety indexes of each ordinary service and ICU nurses were found to be similar (p > 0.05). Conclusions: Ordinary service and ICU nurses' oxidative stress parameters and anxiety indexes were not different and all nurses suffer the similar effects of the shifts both in day and night.Öğe Familial Mediterranean fever without cardinal symptoms and role of genetic screening(Pagepress Publ, 2012) Ulas, T.; Buyukhatipoglu, H.; Bes, C.; Dal, M. S.; Hacibekiroglu, I.; Apucu, H. G.; Borlu, F.Familial Mediterranean fever is an autosomal recessive disorder characterized by paroxysmal episodes of fever and serosal inflammation. The classical presentation is fever and severe recurrent abdominal pain due to serositis that lasts for one to three days and the resolves spontaneously. Between the episodes patients are asymptomatic. Ninety-five percent of patients with familial mediterranean fever have painful episodes localized to the abdomen, which is usually the dominant manifestation of the disease. Herein, we present a case of a 34-year-old man with incomplete abdominal pain episode of familial mediterranean fever limited to the epigastrum and had no cardinals symptoms of this disease. The diagnosis was made by genetic screening. Successful treatment response was achieved by colchicine.Öğe IS THE ELTROMPOBAG TREATMENT SAFE OR EFFECTIVE FOR REFRACTORY CHRONIC IMMUNE THROMBOCYTOPENIA PATIENTS?(Pergamon-Elsevier Science Ltd, 2016) Dal, M.; Karakus, A.; Cakar, M.; Ulu, B.; Hattapoglu, E.; Ekmen, M.; Ulas, T.[Abstract Not Available]Öğe Oxidative stress parameters and ceruloplasmin levels in patients with severe preeclampsia(Soc Editrice Univ, 2013) Demir, M. E.; Ulas, T.; Dal, M. S.; Eren, M. A.; Aydogan, H.; Yalcin, S.; Camuzcuoglu, A.Background. Oxidative stress is believed to have a role in the development of preeclampsia (PE). It is known that an increased ceruloplasmin (CP) level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and CP levels in patients with severe PE. Patients and Methods. Sixty patients with severe PE and 60 healthy pregnant women were recruited to the study. All study subjects were divided into 2 groups; group 1(n=60) consisted of patients with severe PE, and group 2 (n=60) consisted of healthy pregnant subjects. Blood samples were obtained to measure CP, total antioxidant status and total oxidant status from all subjects. Oxidative stress index was calculated. Results. Compared to group 2; group 1 had significantly higher CP, total oxidant status, oxidative stress index and lower total antioxidant status levels (p<0.001, p<0.001, p=0.001, p=0.008, respectively). Serum CP levels were significantly correlated with oxidative stress index levels (r=0.385, p=0.002). Conclusion. The present study demonstrated that both oxidative stress and CP levels increased in patients with PE, and increased CP levels seem to be a consequence of oxidative stress.Öğe Serum uric acid and inflammation in patients with immune thrombocytopenic purpura: preliminary results(Verduci Publisher, 2015) Dal, M. S.; Karakus, A.; Aydin, B. B.; Ekmen, M. O.; Ulas, T.; Ayyildiz, O.OBJECTIVE: The purpose of this study was to evaluate the uric acid (UA) and Creactive protein (CRP) levels in patients with immune thrombocytopenic purpura (ITP). PATIENTS AND METHODS: Forty patients with newly diagnosed ITP and 40 healthy individuals were enrolled in the study. The patients were divided into two groups; group 1 (n = 40) consisted of patients with ITP, and group 2 (n = 40) consisted of healthy subjects. UA and CRP levels were measured in the blood samples from them. RESULTS: There were no statistical differences in gender, age and body mass index between two groups (p > 0.05 for all). Compared to group 2, group 1 had significantly higher UA levels (p = 0.002), whereas CRP levels were not significantly different (p > 0.05). In ITP patients, serum UA and CRP levels significantly correlated with low platelet count (r = -0.362, p = 0.022; r = -0.383, p = 0.015, respectively); and UA levels significantly correlated with CRP levels (r = 0.436, p = 0.005). CONCLUSIONS: The present study showed that UA levels increased in patients with ITP and negatively correlated with platelet counts. UA levels might be a mediator of inflammation via enhanced production of inflammatory cytokines; they might also be a potential mediator of low platelet count, and could play a pathophysiological role in the development of ITP.
