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    Effect of fish oil on indometacin-induced gastric lesions in rats
    (1995) Guzel C.; Ulak G.; Sermet A.; Cicek R.; Ulak M.
    The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats. After indometacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. The ulcer index was found to be decreased to 2.1 ± 1.8 mm with fish oil, 13.7 ± 5.4 mm with olive oil, and 14.6 ± 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indometacin and significantly enhanced the mucus content of the mucosa (p < 0.05).
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    Effect of vitamin B6 intake on tissue zinc levels in the rat
    (1995) Sermet A.; Atmaca M.; Ulak G.; Diken H.; Ulak M.
    Effect of vitamin B6 intake on tissue zinc (Zn) concentrations was investigated in weanling, male Wistar albino rats (100-120 g). The animals were divided into two groups (n = 9) and treated for 4 weeks by intraperitoneal 5 mg/kg/day pyridoxine-HCl or placebo. The Zn content of the liver, spleen, right kidney and right femur were determined. Increases in weight gain in the control and Pyridoxine-treated group were 29.20 ± 1.43% and 51.20 ± 4.53%, respectively (P < 0.001). Dried weights of liver, kidney and femur were significantly higher than those of control group (p < 0.01; p < 0.02; p < 0.001, respectively). No significant difference was observed between the serum Zn concentrations of the experimental and control group (P > 0.05). The Zn content of the liver, spleen, kidney and femur for both total and dry weight per gram of organ weight were significantly higher in the experimental group compared to controls. These findings suggested that pyridoxine affects Zn metabolism in young rats.
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    Protective effect of fish oil against stress-induced gastric injury in rats
    (1995) Ulak G.; Cicek B.; Sermet A.; Guzel C.; Ulak M.; Denli O.
    The effect of fish oil and olive oil on the gastric mucosal damage induced by cold-restraint stress was investigated in rats. The oils were dietary supplemented for 3 weeks. The results demonstrate that a diet containing fish oil, when ingested for 3 weeks before exposure to stress, protected from gastric ulceration significantly (p < 0.01) and led to a statistically significant increase both in mucus and phospholipid content of the gastric mucosal barrier (p < 0.02 and p < 0.001, resp.) in cold-restraint stress-induced gastric injury in rats. However, further studies are required to determine the role of dietary fish oils in the prophylaxis and treatment of peptic ulcer.