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Öğe COMPARISON OF THE DURATION OF ULTRASOUND TREATMENT IN PATIENTS WITH KNEE OSTEOARTHRITIS(Springer London Ltd, 2013) Yildirim, Mustafa Aziz; Ones, Kadriye; Ucar, Demet[Abstract Not Available]Öğe Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life(Springer Heidelberg, 2013) Oktayoglu, Pelin; Em, Serda; Tahtasiz, Mehmet; Bozkurt, Mehtap; Ucar, Demet; Yazmalar, Levent; Nas, KemalThis study was carried out to determine the serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis (AS) and to evaluate its correlation with disease activity and quality of life. According to our knowledge, it is the first trial evaluating HMGB1 levels in AS. Serum samples of 30 patients (18 males and 12 females) with AS and 29 healthy controls (HC) (15 females and 14 males) were collected. HMGB1 levels were measured by enzyme-linked immunosorbent assay, activity of disease was assessed according to the Bath AS Disease Activity Index (BASDAI), and functional status of patients was evaluated with Bath AS Functional Index (BASFI). Modified Schober, chest expansion values and AS Quality of Life Questionnaire (ASQoL) scores were noted. The serum levels of HMGB1 were obtained significantly increased in AS patients compared to HC (p < 0.05). There was no significant correlation between HMGB1 levels and ESR (p > 0.05), and CRP (p > 0.05) values. BASDAI, BASFI and ASQoL scores were also not correlated with serum levels of HMGB1 (p > 0.05). Our results suggest that HMGB1 might play an important role in the pathogenesis of AS; however, it seems not to be a good candidate for reflecting disease activity, functional abilities and the quality of life in patients with AS; on the other hand, the increased levels of HMGB1 in patients may open a new dimension for targeting this cytokine as a new therapy option in AS.Öğe EXERCISES IN THE TREATMENT OF ELDERLY PATIENTS WITH KNEE OSTEOARTHRITIS: FACTORS AFFECTING THE EFFICIENCY OF PATIENT EDUCATION(Gunes Kitabevi Ltd Sti, 2013) Onat, Sule Sahin; Unsal Delialioglu, Sibel; Ucar, DemetIntroduction: The aim of this study was to investigate the significance of patient education, factors affecting the education, compliance of patients to exercises and the reasons of nonconformity among elderly patients with knee osteoarthritis. Materials and Method: During the initial assessments of 482 patients with knee OA, information was provided about the disease, and the benefits of exercises were explained and individual exercise programs were designed. After three months, pharmacological treatments and compliance to exercises and the reasons of failure to comply were questioned. Pain levels were measured with Visual Analog Scale (VAS). Results: 60.2% of the patients were found to be not complying with their exercise programs. Rates of literacy and speaking the same language with the doctor among these patients were significantly lower than the group complying with their exercises but the mean age was higher. The most common reasons for not doing the exercises were finding them tiring and boring, doubting their effectiveness and being older. The initial VAS values of both groups were similar, however the control VAS values of the compliant group were significantly lower. Conclusion: Informing the patients with knee osteoarthritis about the significance of management and exercises is of importance for the success of the treatment. In this study, the patient's education level, speaking the same language and factors affecting communication such as hearing loss have emerged as the most important parameters that convince the patients to implement exercises.Öğe Relationship between urinary incontinence and quality of life/depression in elderly patients(Elsevier Taiwan, 2014) Sahin-Onat, Sule; Unsal-Delialioglu, Sibel; Guzel, Ozer; Ucar, DemetPurpose: The aim of this study was to investigate the relationship between urinary incontinence (UI) and quality of life/depression in elderly patients. Methods: The study included a total of 109 elderly adults aged 65 years and older, consisting of 44 patients with and 65 patients without UI. Demographic data were recorded and UI was assessed using a questionnaire. The Standardized Mini-Mental State Examination was used to evaluate cognitive function. Depression status was assessed using the Yesavage Geriatric Depression Scale and quality of life was assessed using Short Form-36 (SF-36) Health Survey scoring. Results: The mean +/- standard deviation (SD) age of the elderly patients with UI was 80.06 +/- 6.25 years; 21 (47.7%) were women and the other 23 (52.3%) were men. The mean +/- SD visual analog scale score for the severity of UI was 6.22 +/- 0.85; the mean +/- SD number of diurnal voidings was 7.20 +/- 0.87 and the mean +/- SD number of nocturnal voidings was 3.81 +/- 0.97. The mean +/- SD depression score of elderly patients with UI was significantly higher than those without UI (p < 0.0001). There was a strong negative correlation between depression and UI (p < 0.0005; r = -0.886). Both the mental and physical scores of the SF-36 quality of life scale were significantly lower in elderly patients with UI than in those without (p < 0.005). An increased risk of depression (5.90-fold) was found in elderly patients with UI compared with those without UI. UI was found to cause a 0.037 point reduction in the physical component score and a 0.055 point reduction in the mental component score; these are statistically significant. Conclusion: UI in elderly adults leads not only the loss of physical abilities, but also to changes in their mental condition. Copyright (C) 2014, Asia Pacific League of Clinical Gerontology & Geriatrics. Published by Elsevier Taiwan LLC.Öğe Retrospective Cohort Study of the Prevalence of Lumbosacral Transitional Vertebra in a Wide and Well-Represented Population(Hindawi Ltd, 2013) Ucar, Demet; Ucar, Bekir Yavuz; Cosar, Yahya; Emrem, Kurtulus; Gumusssuyu, Gurkan; Mutlu, Serhat; Mutlu, BurcuPurpose. The aim of this study is to determine the prevalence of lumbosacral transitional vertebra (LSTV) in a well-represented general population. Methods. For a retrospective cohort study, abdominal radiographs of adult subjects were queried with clear visibility of the vertebral body articulation of the last rib, all lumbar transverse processes, and complete sacral wings. Exclusion criteria included any radiologic evidence of previous lumbosacral surgery that would block our view. A total of 6200 abdominal films were reviewed, and 3607 were identified as being suitable for the measurement of the desired parameters. Results. A total of 3607 subjects were identified as eligible for the study, and 683 (18.9%) were classified as positive for a lumbosacral transitional vertebra. The prevalence of sacralization and lumbarization was found as 17.2% and 1.7%, respectively. The average age at the time of the study was 39.5 +/- 15.2 years (18-86 years). Conclusions. As a result of different opinions, LSTV retains its controversial status. Our prevalence study of the general population will provide assistance for resolution of the controversy. Prevalence studies of the general population with a wide participation will shed light on comparative studies.Öğe THE RISK OF DEPRESSION IN ELDERLY INDIVIDUALS, THE FACTORS WHICH RELATED TO DEPRESSION, THE EFFECT OF DEPRESSION TO FUNCTIONAL ACTIVITY AND QUALITY OF LIFE(Gunes Kitabevi Ltd Sti, 2014) Onat, Sule Sahin; Delialioglu, Sibel Unsal; Ucar, DemetIntroduction: The aim of this study is to determine the increased risk of depression and factors related with depression in elderly individuals, to investigate the effect of depression to functional status and quality of life. Materials and Method: A total of 160 elderly individuals over 65 years old were participated. Demographic data of elderly individuals were enrolled. Standardized Mini Mental Test was used to determine the mental situation, Yesavage Geriatric Depression Scale for risk of depression Functional Activity Score for functional situation and SF-36 health survey scoring for the quality of life. Results: Eighty one of the total elderly participants had risk of depression, 79 ones had not. There were no differences between elderly individuals who had increased risk of depression and had not for sex, marital status, smoking cigarettes. Increased risk of depression was found more in elderly individuals who were illiterate, had more chronic diseases and used much more pills, had knee osteoarthritis and used accessory devices, had low B-12 and folic acid levels. We found functional activity score low in elderly individuals who had increased risk of depression. Both of physical and mental health scores of SF-36 were lower in elderly individuals had increased risk of depression. The progress depression in elderly age, poor functional status was shown to be a risk factor. A linear relationship was found between depression scores and functional activity scores, quality of life scores. Conclusion: Increased risk of depression and related factors in elderly individuals were determined. Increased risk of depression in elderly individuals effects the functional status and quality of life of elderly negatively.Öğe Serum Coenzyme Q10 Levels and Oxidative Status in Patients with Fibromyalgia Syndrome(Taylor & Francis Ltd, 2014) Bozkurt, Mehtap; Oktayoglu, Pelin; Em, Serda; Caglayan, Mehmet; Yuksel, Hatice; Ucar, Demet; Batmaz, IbrahimObjectives: The aim of this study was to determine the relationship between serum coenzyme Q10 [CoQ10] levels and symptoms of fatigue associated with fibromyalgia syndrome [FMS]. Methods: Patients diagnosed with primary FMS and domographically matching healthy normal controls [HNCs] were sought to participate in the study. The total antioxidant status, total oxidative status, and CoQ10 levels were measured in blood samples from the patients and the controls. Results: A total of 40 patients with FMS and 30 HNCs were recruited. There were no statistically significant differences between the two groups in regard to C-reactive protein, mean erythrocyte sedimentation rate, mean age, and mean body mass index [p>0.05]. The mean time from symptom onset to diagnosis for the FMS patients was 2.88 years, and the average number of tender points was 14. The serum CoQ10 levels were significantly lower in the FMS patients compared with the HNC group [p=0.000]. The serum total oxidative status and oxidative stress index levels were higher, and the serum total antioxidant status levels were lower in the FMS patients compared with those of the HNC group [p<0.05]. The visual analog scale [VAS] pain scores and the VAS fatigue scores were significantly higher in the FMS group than in the HNC group [p=0.000]. The serum CoQ10 levels were negatively correlated with the mean Modified Fatigue Impact Scale scores [p=0.02, r=0.301, VAS pain scores [p=0.00, r=0.38], and VAS fatigue scores [p=0.03, r=0.28]. Conclusions: The CoQ10 deficiency may contribute to the etiopathogenesis of FMS fatigue.Öğe Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia(Wiley, 2013) Oktayoglu, Pelin; Tahtasiz, Mehmet; Bozkurt, Mehtap; Em, Serda; Ucar, Demet; Yazmalar, Levent; Mete, NuriyeAim: High mobility group box 1 protein (HMGB1) is a proinflammatory cytokine. Previous studies have suggested that HMGB1 can play an important role in the pathogenesis of many rheumatic diseases. The purpose of this study was to investigate the serum levels of HMGB1 in patients with fibromyalgia (FM) and its association with quality of life and psychological and functional status in these patients. Methods: Twenty-nine patients who met the 1990 American College of Rheumatology (ACR) criteria for the classification of FM and 29 healthy controls (HC) were included in the present study. Serum samples were collected from both the patients and the HC, and HMGB1 levels were measured by enzyme-linked immunosorbent assay (ELISA). The Fibromyalgia Impact Questionnaire (FIQ) was used to assess the disease severity and functional status in patients with FM. Furthermore, the Nottingham Health Profile was used to assess quality of life in all subjects, as well as the Hospital Anxiety and Depression Scale (HADS) to assess depression and anxiety. Results: The serum levels of HMGB1 protein were positively correlated with the FIQ scores in patients with FM (P = 0.002). Mean serum levels of HMGB1 were higher in patients with FM than in HC but this difference was not statistically significant. Conclusion: HMGB1 protein might be a good laboratory-sourced candidate for the assessment of functional status and disease severity in patients with FM.Öğe Serum prolidase Activity in Ankylosing spondylitis and Rheumatoid Arthritis(Sage Publications Ltd, 2013) Ucar, Demet; Em, Serda; Bozkurt, Mehtap; Oktayoglu, Pelin; Yuksel, Hatice Kurt; Caglayan, Mehmet; Gezer, OrhanThe aim of the present study was to emphasize the collagen turnover in 2 of the most common chronic inflammatory rheumatic diseases by evaluating serum prolidase activity (SPA) in ankylosing spondylitis (AS) and rheumatoid arthritis (RA). 30 patients who met the modified New York Criteria for the classification of AS, 29 patients who met the 2010 Rheumatoid Arthritis Classification Criteria for the classification of RA, and 31 healthy controls were enrolled in the study. Serum samples of the patients and the controls were collected and SPA was measured by a spectrophotometric method. The comparison of the SPA in these 3 groups was statistically examined. In both patient groups, the SPA was lower than in the control group. SPA in patients with AS was statistically significantly lower than in the control and RA groups (P, 0.001/P = 0.002). No statistically significant difference was found between the RA and the control groups (P = 0.891). In conclusion, lower SPA is presumably associated with decreased collagen turnover and fibrosis, leading to decreased physical functions in both chronic inflammatory musculoskeletal diseases.Öğe Serum relaxin levels in benign hypermobility syndrome(Ios Press, 2015) Em, Serda; Oktayoglu, Pelin; Bozkurt, Mehtap; Caglayan, Mehmet; Karakoc, Mehmet; Ucar, Demet; Verim, SabahattinOBJECTIVE: In this study, we investigated the activity of serum relaxin in female patients with benign joint hypermobility syndrome (BJHS), locomotor system findings accompanying BJHS, and its relation to relaxin. METHODS: Into the study, female patients with BJHS and healthy women as the control group were included. The patients were diagnosed by using the Brighton 1998 criteria. Examination of the locomotor system for study groups were performed. Serum relaxin levels of both patient and control group were measured. RESULTS: There were 48 female patients with BJHS and 40 healthy women in the study. With respect to the control group, the level of serum relaxin was higher in the patients (47.1 +/- 20.3, 34.4 +/- 22.1; p > 0.05). Again compared with the control group, arthralgia (p = 0.00), myalgia (p = 0.01), shoulder impingement syndrome (p = 0.05), pes planus (p = 0.01), and hyperkyphosis (p = 0.000) were higher in the patients. The level of relaxin median was significantly higher in the patients with pesplanus and hyperkyphosis than those who did not have them (p = 0.05, p = 0.01, respectively). CONCLUSIONS: Although serum relaxin level is not considered a causative factor for BJHS, the significant increases found in those patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS.Öğe Temporomandibular dysfunction syndrome: A prospective study of 255 consecutive patients(Sage Publications Ltd, 2013) Ucar, Demet; Diracoglu, Demirhan; Karan, AyseObjective To determine the relationship between temporomandibular dysfunction syndrome (TMDS), sex and pain severity. Methods Data were collected prospectively from consecutive patients with TMDS. Patients were divided into four subgroups according to signs and symptoms: myofascial pain; intra-articular disorders; extra-articular disorders; degenerative disorders. Intergroup sex distribution differences were evaluated, the pain severity between the four subgroups was compared, and the rates of bruxism and inco-ordination were measured. A visual analogue scale was used to rate the pain. Results A total of 255 patients with TMDS were included in the study. A significantly higher rate of extra-articular disorders was found in male patients. Bruxism was found to be significantly more common in females than in males. There was no significant difference in the prevalence of inco-ordination based on sex. The overall pain score was higher in females than in males, but there was no significant difference. The pain score was significantly higher in patients in the degenerative disorders subgroup, compared with other subgroups. Conclusions There was no relationship between TMDS and pain and sex. Pain scores were significantly higher in the degenerative disorders subgroup, compared with other subgroups.
