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Öğe Effects of mesenchymal stem cells in critical size bone defect(Verduci Publisher, 2012) Agacayak, S.; Gulsun, B.; Ucan, M. C.; Karaoz, E.; Nergiz, Y.Background and Objectives: The aim of this study was to compare culture-expanded, bone marrow-derived mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) loaded to biphasic calcium phosphate (BCP) bone ceramic in the repair of rat calvarial bone. Materials and Methods: Critical-size (7 mm dia.) calvarial defects were prepared in the frontal-parietal bones of 90 adult female Sprague-Dawley rats. Rats were randomly divided into 5 groups, according to defect filling, as follows: Group I (n=21), BCP; Group II (n=21), BCP+PRP; Group III (n=21), BCP+MSC; Group IV (n=21), BCP+PRP+MSC; Group V (n=6) (control), no treatment. Animals were sacrificed at 2, 8 and 12 weeks postsurgery and bone regeneration was evaluated both histologically and immunohistochemically. Results: Statistically significant differences were observed in bone osteoblastic activity in calvarial defects among the groups (p < 0.05). PRP and MSC used in combination with BCP as a defect filling resulted in greater osteoblastic bone formation activity when compared to the use of BCP alone. Conclusions: The combination of mesenchymal stem cells, platelet rich plasma and synthetic bone substitute was found to be more effective in inducing new bone formation (osteogenesis) than the use of platelet rich plasma combined with synthetic bone substitute and the use of synthetic bone substitute alone.Öğe Influence of caffeic acid phenethyl ester on bone healing in a rat model(Sage Publications Ltd, 2013) Ucan, M. C.; Koparal, M.; Agacayak, S.; Gunay, A.; Ozgoz, M.; Atilgan, S.; Yaman, F.Objective To examine the effects of caffeic acid phenethyl ester (CAPE; a component of honey bee-hive propolis with antioxidant, anti-inFLammatory, antiviral and anticancer properties) on bone regeneration and fibrotic healing in a rat model. Methods Male Sprague-Dawley rats (n=63; mean age 7 weeks; weight 280-490g) were randomly divided into three groups: A, cranial defect with no bone healing treatment (n=21); B, cranial defect treated with CAPE (n=21); C, cranial defect treated with CAPE and -tricalcium phosphate/hydroxyl apatite (n=21). Rats were anaesthetized with ketamine (8mg/100g) by intraperitoneal injection and a cranial critical size bone defect was created. Following surgery, CAPE (10 mu mol/kg) was administered by daily intraperitoneal injection. Seven rats in each group were killed at days 7, 15 and 30 following surgery. Bone regeneration, fibrotic healing and osteoblast activity were evaluated by histopathology. Results Statistically significant differences in healing were found between all groups. There were no statistically significant within-group differences between day 7 and 15. At day 30, bone healing scores were significantly higher in groups B and C compared with group A. Conclusion CAPE significantly improved bone-defect healing in a rat model, suggesting that CAPE has beneficial effects on bone healing.Öğe Phosphodiesterase-5 inhibitors may facilitate bone defect recovery(Verduci Publisher, 2011) Yaman, F.; Atilgan, S.; Gunes, N.; Agacayak, S.; Gunay, A.; Ucan, M. C.; Bakir, S.Background and Objectives: Bone healing is still one of the most important problems of the oral and maxillofacial surgery procedures. This study was designed to evaluate the effect of sildenafil citrate (which is used for erectile dysfunction) on bone defect healing in an experimental animal model. Materials and Methods: A total of 42 male Wistar-albino rats were randomly assigned to the control group (n=21) or the study group (n=21). The control group was fed on a standard laboratory diet until 12 h before surgery, whereas the study group received Sildenafil citrate via orogastric tube 10 mg/kg once a day for 30 days. Under anaesthesia, a 3x3x2 mm depth defect was made on tibia of each rat. 7 animals from each group were euthanised on postoperative days 7,15 and 30. Bone samples were taken for examination, histologically on day 7, by 3D dental tomography on day 15, and for bone strength resistance on day 30. Results: Statistically significant differences were determined between the groups from the inflammatory and repair phase, with the healing process being more advanced in the Sildenafil group. Conclusions: Sildenafil citrate can be used as a supporting factor to accelerate the healing process of bone. In future comprehensive studies will need to demonstrate the Sildenafil citrate affect on bone defect healing.Öğe A THREE DIMENSIONAL ANALYSIS OF RECONSTRUCTION PLATES USED IN DIFFERENT MANDIBULAR DEFECTS(Taylor & Francis Ltd, 2010) Atilgan, S.; Erol, B.; Yardimeden, A.; Yaman, F.; Ucan, M. C.; Gunes, N.; Atalay, Y.In this study, the reasons of breaking of the reconstruction plates used in mandibular continuity or mandibular defects were investigated. The study was conducted on 3 cases in which reconstruction plates were used for tumor resection or invasive wound. The objective was to evaluate the mechanical stress in reconstruction plates by means of the finite element method. Three dimensional model of reconstruction plate was exposed to chewing force. A commercial finite element solver (ANSYS) was then applied to this plate to compute the stresses generated in chewing situation. Stress analyses have been carried out by applying Von Mises Yielding Criteria. In the standard reconstruction plate, the results of the finite element analysis revealed that stress resulting from the simulated functional loadings which far exceeded the strengths of the components. The main application of this study was the prediction of fractures as a consequence of known forces. If it was assumed that the patient executes several thousand masticatory movements within a week, a dynamic strain would be present due to the large number of changes in loading, so that there was a danger of a fatigue fracture at the point of the stress concentration (as seen in the analysis), as is also confirmed by clinical practice.
