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    EFFECT OF FISH-OIL ON INDOMETHACIN-INDUCED GASTRIC-LESIONS IN RATS
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1995) GUZEL, C; ULAK, G; SERMET, A; CICEK, R; ULAK, M
    The effect of fish oil in promoting the healing of indometacin-induced gastric lesions was investigated in Wistar albino rats, After indometacin treatment (30 mg/kg, s.c.), animals were given fish oil, olive oil, or normal diet for 48 h. Thr ulcer index was found to be decreased to 2.1 +/- 1.8 mm with fish oil 13.7 +/- 5.4 mm with olive oil, and 14.6 +/- 2.4 mm with normal diet. Fish oil showed a potent healing-promoting effect on acute gastric erosions and ulcers induced by indometacin anti significantly, enhanced the mucus content of the mucosa (p < 0.05).
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    PROTECTIVE EFFECT OF FISH-OIL AGAINST STRESS-INDUCED GASTRIC INJURY IN RATS
    (Ecv-Editio Cantor Verlag Medizin Naturwissenschaften, 1995) ULAK, G; CICEK, R; SERMET, A; GUZEL, C; ULAK, M; DENLI, O
    The effect of fish oil and olive oil on the gastric mucosal damage induced by cold-restraint str ess !:as investigated in rats. The oils were dietary supplemented for 3 weeks. The results demonstrate that a diet containing fish oil when ingested for 3 weeks before exposure to stress, protected from gastric ulceration significantly (p < 0.01) and led to a statistically significant increase both in mucus and phospholipid con tent of the gastric mucosal barrier (p < 0.02 and p < 0.001, resp.) in cold-restraint stress-induced gastric injury in rats. However; further studies are required to determine the role of dietary fish oils in the prophylaxis and treatment of peptic ulcer.