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  • Küçük Resim
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    Diagnosis and treatment of aspergillosis in an ostrich flock
    (Kafkas Üniversitesi Veteriner Fakültesi, 2011) İçen, Hasan; Işık, Nurettin; Alp, Simten Yeşilmen; Tuzcu, Mehmet; Sekin, Servet
    This study consists of the clinical, microbiological and pathological findings, and the results of Amphoterisin B and Biostarter for supported treatment, of focal aspergillosis in a flock of ostriches. The clinical signs were listlessness, anorexia, diarrhoea, increased respiration, dyspnoea, and mucoid discharge from the nostrils. At post-mortem examination caseous nodules were observed in various organs. Histopathological examination of the lungs, air sacs and the pleural membrane showed in different sizes in different parts of necrosis in the center of the surrounding foreign body giant cells, epitheloid macrophages, lymphocytes and granulomas surrounded by a fibrous connective tissue. In treatment, Amphotericin B and Biostarter was given orally as a supported treatment. There were no sick birds after the treatment. As a conclusion, aspergillosis could be treated with amphotericin B and as a supported treatment Biostarter, especially in the early stages of the disease.
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    Impact of chromium histidinate on high fat diet induced obesity in rats
    (Bmc, 2011) Tuzcu, Mehmet; Sahin, Nurhan; Orhan, Cemal; Agca, Can Ali; Akdemir, Fatih; Tuzcu, Zeynep; Komorowski, James
    Background: Chromium (Cr) is an essential trace element that has garnered interest for use as a weight loss aid, but its molecular mechanism in obesity is not clear. In this study, an attempt has been made to investigate the effects of chromium histidinate (CrHis) on glucose transporter-2 (GLUT-2), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), nuclear factor-kappa B (NF-kappa B p65) and the oxidative stress marker 4-hydroxynonenal adducts (HNE) expressions in liver of rats fed high fat diet (HFD). Methods: Male Wistar rats (n = 40, 8 wk-old) were divided into four groups. Group I was fed a standard diet (12% of calories as fat); Group II was fed a standard diet and supplemented with 110 mu g CrHis/kg BW/d; Group III was fed a HFD (40% of calories as fat); Group IV was fed HFD and supplemented with 110 mu g CrHis/kg BW/d. Results: Rats fed HFD possessed greater serum insulin (40 vs. 33 pmol/L) and glucose (158 vs. 143 mg/dL) concentration and less liver Cr (44 vs. 82 mu g/g) concentration than rats fed the control diet. However, rats supplemented with CrHis had greater liver Cr and serum insulin and lower glucose concentration in rats fed HFD (P < 0.05). The hepatic nuclear factor-kappa B (NF-kappa B p65) and HNE were increased in high fat group compared to control group, but reduced by the CrHis administration (P < 0.05). The levels of hepatic Nrf2 and HO-1 were increased by supplementation of CrHis (P < 0.05). Conclusion: These findings demonstrate that supplementation of CrHis is protective against obesity, at least in part, through Nrf2-mediated induction of HO-1 in rats fed high fat diet.
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    Phytochemical profiling and biological activity of Achillea sintenisii Hub.-Mor
    (John Wiley and Sons Inc., 2023) Eruygur, Nuraniye; Büyükyıldırım, Tuğsen; Rama, Şeyma Tetik; Ayaz, Fatma; Tekin, Mehmet; Tuzcu, Mehmet; Yılmaz, Mustafa Abdullah
    Achillea (Asteraceae) species have been traditionally used for their different therapeutical properties. In this study, phytochemical composition of aerial parts of A. sintenisii which is endemic in Turkey was determined with Liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS). To evaluate the wound healing potential, the cream formulation prepared from A. sintenisii was tested on the linear incision wound model in mice. In vitro enzyme inhibitory activity tests were performed on elastase, hyaluronidase, and collagenase. In the histopathological examination, angiogenesis and granulation tissue formation were significantly increased in A. sintenisii treatment groups compared to the negative control group. As a result of this study, it is thought that the enzyme inhibition and antioxidant activity of the plant may contribute to the wound healing process. According to LC/MS/MS analysis result, quinic acid (24.261 μg/mg extract) and chlorogenic acid (14.97 μg/mg extract) were identified as main constituents of the extract.