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Öğe Accelerated corneal collagen cross-linking for progressive keratoconus(Taylor & Francis Ltd, 2014) Cinar, Yasin; Cingu, Abdullah Kursat; Turkcu, Fatih Mehmet; Yuksel, Harun; Sahin, Alparslan; Yildirim, Adnan; Caca, IhsanPurpose: To evaluate the efficacy of accelerated corneal cross-linking (CXL) procedure for progressive keratoconus. Materials and methods: Twenty-three eyes of 23 patients undergone accelerated CXL procedure were evaluated preoperatively and postoperatively at 1st, 3rd and 6th month for uncorrected distant visual acuity (UDVA), best corrected distant visual acuity (CDVA), spherical error, cylindrical error, spherical equivalent (SE), keratometric values and thinnest corneal thickness (TCT) values with corneal topography by Scheimpflug camera and endothelial cell density (ECD). Results: The mean UDVA was improved from 0.97 +/- 0.41 logarithm of minimal angle of resolution (logMAR) to 0.76 +/- 0.45 logMAR at the 6th month after CXL (p = 0.332). The mean CDVA was improved from 0.49 +/- 0.30 logMAR to 0.34 +/- 0.22 logMAR at the 6th month after CXL (p = 0.026). The mean sphere was decreased from -4.47 +/- 4.1 diopter (D) to -3.79 +/- 3.86 D and the mean cylinder was decreased from -5.60 +/- 2.2D to -4.55 +/- 1.98 D and the mean SE was decreased from -7.22 +/- 4.48 D to -6.36 +/- 4.34 D at the 6th month after CXL (p = 0.128, p = 0.002 and p = 0.045, respectively). Flat keratometry, steep keratometry, mean keratometry and maximum keratometry were significantly reduced at the 6th month after CXL (p = 0.025, p < 0.001, p = 0.004 and p = 0.03, respectively). TCT and ECD were not changed significantly the 6th month after CXL (p = 0.135 and p = 0.082, respectively). Conclusion: Accelerated CXL procedure was effective to stabilize progression of keratoconus with significant reduction in topographic keratometric values and significant increase in CDVA in 6 months.Öğe Activation of toxoplasma retinochoroiditis during pregnancy and evaluation of ocular findings in newborns(Springer, 2017) Turkcu, Fatih Mehmet; Sahin, Alparslan; Yuksel, Harun; Cinar, Yasin; Cingu, Kursat; Altindag, Suat; Deveci, OzcanThe purpose of this study was to evaluate patients with activation of toxoplasma retinochoroiditis during pregnancy and ocular findings in newborns. A total of 17 pregnant patients who were clinically and serologically diagnosed with ocular toxoplasmosis were retrospectively reviewed. After birth, ocular findings for all infants were recorded. The mean age of the patients was 29.08 +/- 5.71 years. In all cases, activation was present in only one eye. In 13 cases, anterior uveitis was associated with posterior uveitis. Visual acuity in all cases prior to treatment was 0.3 +/- 0.21 and increased to 0.55 +/- 0.29 after treatment. The mean gestational age of the patients was 19.76 +/- 8.71 weeks at the time of hospital admission. No case of toxoplasmic ocular involvement was identified in the infants on postnatal examination. In the case of toxoplasma retinochoroiditis during pregnancy, appropriate treatment and follow-up is very important to protect the newborns and to prevent impaired vision in mothers.Öğe Approach of Turkish ophthalmologists to micronutrition in age-related macular degeneration(Consel Brasil Oftalmologia, 2015) Sahin, Muhammed; Yuksel, Harun; Sahin, Alparslan; Cingu, Abdullah Kursat; Turkcu, Fatih Mehmet; Ozkurt, Zeynep Gursel; Caca, IhsanPurpose: To evaluate the knowledge and behaviors of ophthalmologists in Turkey concerning micronutrition support in patients with age related macular degeneration (ARMD). Methods: This study involved 1,845 ophthalmologists. A scientific poll was sent to all participants by email. The survey covered the following: demographic features, subspecialty knowledge about micronutrition preference for prescribing micronutrition to age related macular degeneration patients, and the reason for this preference. If a participant indicated that he or she prescribed micronutrition, the participant was also asked to indicate the source of the treatment and supplemental treatments. Results: Of 1,845 ophthalmologists, 249 responded to the survey. Of the respondents, 9% (22) never, 43% (107) sometimes, 37% (92) frequently, and 11% (27) always used micronutrition. The most frequent prescribing subgroup was general ophthalmology (22%), followed by the retina-uvea subspecialty (13.9%). The micronutrition prescribing ratio was 54.8% in retina-uvea specialists when the frequent and always responses were combined. There was no statistically significant difference between subgroups with respect to prescribing micronutrition. Among the ophthalmologists prescribing micronutrition, 57.1% of them did not use the Age-Related Eye Disease Study-1 (AREDS) criteria, and only 31.3% prescribe micronutrition according to AREDS criteria. The results for the general ophthalmologist and retina-uvea specialist subgroups were similar, 56.3% vs 20.2%, and 54.1% vs 36.1%, respectively. Micronutrition was not recommended for the following reasons: expensive (55.4%), low patient expectancy (40%), no effect (30%), and low patient drug compliance (25.4%). Moreover, 55.2% of the clinicians recommended physical activities, dietary changes, and smoking cessation; 7.3% did not recommend these behavioral changes. Conclusion: This survey demonstrated that micronutrition preference in age related macular degeneration was low in ophthalmologists in Turkey. Additionally, retina specialists have a lower rate of prescribing micronutrition. Micronutrition support and behavior such as smoking cessation, dietary changes, etc. should be recommended more often to patients with age related macular degeneration.Öğe AUTHOR REPLY TO: Mean platelet volume in pseudoexfoliation syndrome and glaucoma(Wichtig Editore, 2014) Turkcu, Fatih Mehmet; Yuksel, Harun; Sahin, Alparslan; Cinar, Yasin; Yuksel, Hatice; Cingu, Kursat; sahin, Muhammed[Abstract Not Available]Öğe Author reply: approach to micronutrition in age-related macular degeneration(Consel Brasil Oftalmologia, 2015) Sahin, Muhammed; Sahin, Alparslan; Turkcu, Fatih Mehmet[Abstract Not Available]Öğe Automated quantification of foveal avascular zone and vascular density in Behcet's disease(Springer London Ltd, 2020) Turkcu, Fatih Mehmet; Sahin, Alparslan; Karaalp, Umit; Cinar, Yasin; Sahin, Muhammed; Ozkurt, Zeynep Gursel; Keklikci, UgurPurposeTo measure the vascular density (VD) and foveal avascular zone (FAZ) area in patients with Behcet's disease (BD) obtained by optical coherence tomography angiography (OCTA).MethodsVD and FAZ area in the deep and superficial retinal vascular networks were measured in all eyes.ResultsThirty BD and 31 control subjects were included in the study. The mean overall VD measured in the entire scan was lower in BD compared with control group in both the superficial (49.526.54 vs 53.57 +/- 2.87%, respectively; p=0.003) and deep (53.44 +/- 7.44 vs 58.41 +/- 3.01%, respectively; p=0.002) areas. The FAZ in the BD group was significantly increased at the level of the superficial (0.52 +/- 0.67 vs 0.28 +/- 0.1 mm(2), respectively; p=0.05) and deep (0.91 +/- 1.25 vs 0.39 +/- 0.14 mm(2), respectively; p=0.024) areas compared with those of the control group. The deep and the superficial FAZ areas were positively correlated with disease duration and negatively with VA.Conclusionp id=ParIn the patients with BD, OCTA showed decreased VD in both the superficial and deep retinal vascular networks. Besides, the VA was correlated with the VD and FAZ.Öğe Cellular Debris in the Anterior Vitreous in Silent Eyes of Behcet Patients as a Clue of Asymptomatic Ocular Involvement(Hindawi Ltd, 2013) Cingu, Abdullah Kursat; Turkcu, Fatih Mehmet; Yeniad, Baris; Tugal-Tutkun, IlknurPurpose. To investigate if there is a prognostic implication of the presence of cellular debris in the anterior vitreous in patients with Behcet's disease (BD) without any ocular symptoms. Methods. One hundred and twenty eyes of 60 patients with BD were included in the study. The eyes were divided into two groups according to the presence of cellular debris in the anterior vitreous. The first group included 54 eyes which were cellular debris (+) (group A), and the second group included 66 eyes which were cellular debris (-) (group B). Fluorescein angiography (FA) was performed to all patients following routine ocular examination. Patients were called for the six monthly control visits to investigate possible new ocular involvement during followup. The Kaplan-Meier method was used to estimate survival curves. Results. Seven eyes (13%) in group A and four eyes (6.1%) in group B showed optic disc hyperfluorescence on FA (P = 0.2). None of the eyes with disc hyperflourescence on initial examination developed uveitis attacks in their followup. In Kaplan-Meier survival analysis there was a significant difference between the groups (group A 20.6% and group B 4.2%) by means of ocular involvement during their followup (log-rank = 6.85, P = 0.009). Conclusions. Presence of cellular debris in the anterior vitreous may have prognostic implications in patients with BD screened for ocular involvement.Öğe Central serous chorioretinopathy due to tadalafil use(Springer, 2013) Turkcu, Fatih Mehmet; Yuksel, Harun; Sahin, Alparslan; Murat, Mehmet; Bozkurt, Yasar; Caca, IhsanPhosphodiesterase-5 (PDE5) inhibitors are commonly used in the treatment of erectile dysfunction. There are a small number of case reports that associate this agent with central serous chorioretinopathy (CSCR). Our report presents the treatment approach to a 42-year-old patient who described blurred vision and metamorphopsia and was diagnosed with CSCR following the use of tadalafil, a PDE5 inhibitor.Öğe Comparison of accelerated and conventional corneal collagen cross-linking for progressive keratoconus(Taylor & Francis Ltd, 2014) Cinar, Yasin; Cingu, Abdullah Kursat; Turkcu, Fatih Mehmet; Cinar, Tuba; Yuksel, Harun; Ozkurt, Zeynep Gursel; Caca, IhsanPurpose: To compare outcomes of accelerated and conventional corneal cross-linking (CXL) for progressive keratoconus (KC). Materials and methods: Patients were divided into two groups as the accelerated CXL group and the conventional CXL group. The uncorrected distant visual acuity (UDVA), corrected distant visual acuity (CDVA), refraction and keratometric values were measured preoperatively and postoperatively. The data of the two groups were compared statistically. Results: The mean UDVA and CDVA were better at the six month postoperative when compared with preoperative values in two groups. While change in UDVA and CDVA was statistically significant in the accelerated CXL group (p = 0.035 and p = 0.047, respectively), it did not reach statistical significance in the conventional CXL group (p = 0.184 and p = 0.113, respectively). The decrease in the mean corneal power (K-m) and maximum keratometric value (K-max) were statistically significant in both groups (p = 0.012 and 0.046, respectively in the accelerated CXL group, p = 0.012 and 0.041, respectively, in the conventional CXL group). There was no statistically significant difference in visual and refractive results between the two groups (p > 0.05). Conclusions: Refractive and visual results of the accelerated CXL method and the conventional CXL method for the treatment of KC in short time period were similar. The accelerated CXL method faster and provide high throughput of the patients.Öğe Comparison of Central Corneal Thickness Measurements with a Rotating Scheimpflug Camera, a Specular Microscope, Optical Low-Coherence Reflectometry, and Ultrasound Pachymetry in Keratoconic Eyes(Taylor & Francis Inc, 2015) Cinar, Yasin; Cingu, Abdullah Kursat; Turkcu, Fatih Mehmet; Cinar, Tuba; Sahin, Alparslan; Yuksel, Harun; Ari, SeyhmusObjective: To compare central corneal thickness (CCT) measurements with a rotating Scheimpflug camera (RSC), noncontact specular microscopy (SM), optical low-coherence reflectometry (OLCR), and ultrasonic pachymetry (UP) in keratoconus (KC) patients. Method: In this prospective study, four CCT measurements taken with an RSC, SM, OLCR, and UP were compared in 81 eyes of 44 consecutive KC patients. The KC patients were divided into four subgroups according to Amsler-Krumeich's KC classification. Results: The RSC and UP measurements of the CCT were not statistically significant in all the groups. Comparison of the SM vs. the OLCR measurements yielded statistically significant differences in all the KC patients and in all KC stages. In all the KC patients, RSC and OLCR showed a high correlation coefficient factor (r = 0.87, p = 0.000). Conclusion: CCT measurements with RSC are comparable to those achieved with UP. Compared with the other devices, according to SM measurements, the central cornea is thicker in all keratoconic eyes and in all KC grades, and it is thinner according to OLCR. RSC, UP, SM, and OLCR should not be used interchangeably in keratoconic eyes.Öğe Comparison of Optical versus Ultrasonic Biometry in Keratoconic Eyes(Hindawi Ltd, 2013) Cinar, Yasin; Cingu, Abdullah Kursat; Sahin, Muhammed; Sahin, Alparslan; Yuksel, Harun; Turkcu, Fatih Mehmet; Cinar, TubaPurpose. To compare the measurements of optical versus ultrasonic biometry devices in keratoconic eyes. Materials and Methods. Forty-two eyes of 42 keratoconus (KC) patients enrolled in the study were examined. Clinical and demographic characteristics of the patients were noted, and detailed ophthalmological examination was performed. Following Pentacam measurements, central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), and axial length (AL) were obtained using the Lenstar and US biometer to determine the reproducibility of the measurements between the two devices in keratoconic eyes. The Bland-Altman method was used to describe the agreement between the two devices. Results. The Lenstar could not measure at least one of the biometric properties in one eye and did not automatically give the corrected ACD in 2/3 of our study population. The Lenstar measured CCT (average difference 5.4 +/- 19.6 mu m; ICC = 0.90; P < 0.001), LT (average difference 0.13 +/- 0.17 mm; ICC = 0.67; P < 0.001), and AL (average difference 0.10 +/- 0.76 mm; ICC = 0.75; P < 0.001) thinner than US biometer, whereas it measured ACD (average difference 0.18 +/- 0.17 mm; ICC = 0.85; P < 0.001) deeper than US biometer in keratoconic eyes. Conclusion. Although the difference between the measurements obtained using the two devices might be clinically acceptable, US biometry and Lenstar should not be used interchangeably for biometric measurements in KC patients.Öğe Corneal perforation during Nd:YAG laser capsulotomy: a case report(Springer, 2013) Turkcu, Fatih Mehmet; Yuksel, Harun; Cingu, Kursat; Cinar, Yasin; Murat, Mehmet; Caca, IhsanWe report a case where corneal perforation developed during Nd:YAG laser capsulotomy. We present a 20-year-old male with the complaint of impaired vision in the right eye. Leukoma consistent with the incision line in the cornea and opacity in the posterior capsule were observed.Öğe Demographic and etiologic characteristics of children with traumatic serious hyphema(Turkish Assoc Trauma Emergency Surgery, 2013) Turkcu, Fatih Mehmet; Yuksel, Harnn; Sahin, Alparslan; Cingu, Kursat; Ari, Seyhmus; Cinar, Yasin; Sahin, MuhammedBACKGROUND We aimed to evaluate the etiologic factors, complications, follow-up, and treatment outcomes in serious hyphema following blunt ocular trauma in childhood. METHODS The medical records of 136 patients diagnosed as grade 3 or 4 hyphema due to blunt ocular trauma between January 2006 and December 2011 were evaluated. Visual acuity (VA), complications, and medical and surgical treatments were analyzed. Factors affecting visual prognosis were compared in grade 3 and 4 hyphema cases. RESULTS The mean age of patients was 9.7+/-4 years. Etiologic factors for trauma were stone in 53 (39%), bead bullet in 25 (18.4%) and others in 58 (42.6%) patients. The most common complication of grade 3 and 4 hyphema was traumatic mydriasis (19.1%), followed by cataract (9.6%) and glaucoma (5.1%). Medical treatment was successful in 114 (83.8%) patients, and 22 (16.2%) patients underwent surgery. Mean initial and final VA of grade 4 patients were found to be significantly lower than those of grade 3 patients. CONCLUSION In grade 3 and 4 hyphema due to blunt trauma, visual prognosis worsened in the presence of additional ocular pathologies. Considering the bad visual prognosis of severe hyphema patients, prompt treatment and close follow-up may prevent complications resulting in poor VA.Öğe Diagnosis of Malignant Hypertension with Ocular Examination: A Child Case(Informa Healthcare, 2014) Yildirim, Adnan; Turkcu, Fatih Mehmet; Yuksel, Harun; Sahin, Alparslan; Cinar, Yasin; Caca, IhsanA 12-year-old female patient was admitted to our clinic complaining about low vision. Bilateral optic disc edema, macular star, and preretinal hemorrhages were found in fundoscopic examination. In fundus fluorescein angiography, massive leakage in the late phase was seen in the optic nerve head and macular area. These findings were compatible with high-grade hypertensive retinopathy. The patient consulted with pediatrics and a diagnosis of vesicourethral reflux and malignant hypertension was made.Öğe Early detection of macular and peripapillary changes with spectralis optical coherence tomography in patients with prediabetes(Taylor & Francis Ltd, 2018) Sahin, Muhammed; Sahin, Alparslan; Kilinc, Faruk; Karaalp, Umit; Yuksel, Harun; Ozkurt, Zeynep Gursel; Turkcu, Fatih MehmetPurpose: To compare the retina ganglion cell complex (GCC) layer and peripapillary nerve fibre layer thickness (pRNFL) in patients with prediabetes and healthy subjects analysed by spectral domain optical coherence tomography (SD-OCT). Methods: This cross-sectional and comparative study included prediabetic patients and healthy subjects. All participants underwent SD-OCT measurement of pRNFL thickness, and GCC thickness. Results: A total of 30 eyes of the 30 patients with prediabetes and 30 eyes of 30 controls were included. The overall calculated pRNFL thicknesses were similar between the prediabetic and control subjects. The GCC thickness was significantly lower in all quadrants of the inner macula, and outer nasal quadrant in the prediabetes group when compared to the control group. Conclusion: Our study demonstrated that inner macular GCC thickness was significantly thinner in prediabetic subjects. As a result neurodegeneration may play role in the thinning of GCC.Öğe Effect of Vernal Keratoconjunctivitis on Vitreous Depth in Patients with Keratoconus(Informa Healthcare, 2015) Cingu, Abdullah Kursat; Kaya, Savas; Cinar, Yasin; Sahin, Muhammed; Turkcu, Fatih Mehmet; Yuksel, Harun; Murat, MehmetPurpose: The aim of this study was to comparatively evaluate the vitreous depth (VD) of keratoconic eyes in patients with or without vernal keratoconjunctivitis (VKC). Material and Methods: Eighty eyes of 80 consecutive keratoconus (KC) patients and 40 emmetropic control subjects were enrolled. KC patients were divided into two groups according to accompanying VKC (VKC-KC group and KC group). Mean outcome measures were best-corrected visual acuity (BCVA), spherical equivalent (SE), mean keratometry (Km), intraocular pressure (IOP), and axial length (AL) and its components. The eyes with the highest Km were selected for statistical analysis for each participant. Results: There were 50, 30, and 40 patients in the VKC-KC group, KC group, and control group respectively. The KC group and VKC-KC group were similar in BCVA, SE, Km, CCT, ACD, LT, and IOP (p>0.05). The mean ACD was significantly lower in the control group when compared with the KC group and VKC-KC group. The mean AL and VD were significantly higher in VKC-KC group than those of KC group and the control group, whereas similar in KC and control groups (p>0.05). Conclusion: In the current study we showed that VKC-associated KC patients have significantly longer AL and VD when compared with KC patients without VKC. Posterior segment elongation in VKC-KC group may be associated with the type IV collagen destruction due to chronic longstanding inflammation in VKC patients.Öğe Effective dose of bevacizumab for the treatment of retinopathy of prematurity(Consel Brasil Oftalmologia, 2018) Sahin, Alparslan; Turkcu, Fatih Mehmet; Sahin, Muhammed[Abstract Not Available]Öğe The effects of caffeic acid phenethyl ester in acute methanol toxicity on rat retina and optic nerve(Taylor & Francis Ltd, 2013) Sahin, Alparslan; Kaya, Savas; Turkcu, Gul; Cingu, Abdullah Kursat; Yuksel, Harun; Turkcu, Fatih Mehmet; Yuksel, HaticePurpose: We aimed to test caffeic acid phenethyl ester (CAPE) as an antidote for acute methanol (MeOH) toxicity and to compare it with ethanol. Methods: This study included five groups, each containing eight rats. The groups were control, methotrexate (MTX), MeOH, ethanol and CAPE. All rats except control group were treated with intraperitoneal (i.p.) MTX (0.3 mg/kg/d) for 7 d. At the 8th day of the experiment, i.p. injection of MeOH (3 g/kg) was administered in MeOH, ethanol and CAPE groups. Four hours after MeOH treatment, 0.5 g/kg ethanol was injected i.p. in ethanol group; 10 mu mol/kg CAPE i.p. in CAPE group; serum physiologic i.p. in other groups. After 8 h, rats were anaesthetized and sacrificed. Total anti-oxidant status (TAS), total oxidant status (TOS) were measured on the dissected and excised retina and optic nerve samples. Fellow eyes were used for histopathologic evaluation and the cell count of retinal ganglion cell (RGC) layer. In addition, interactions of alcohol dehydrogenase with CAPE, ethanol, MeOH and pyrazole derivatives were investigated. Results: Either CAPE or ethanol co-treatment decreased the TOS levels and increased the TAS levels compared to the MeOH group. MeOH treatment decreased the mean cell count in RGC layer. CAPE co-treatment significantly prevented cell loss (p=0.040). Besides, in silico calculations showed that binding affinity of CAPE to alcohol dehydrogenase was higher than those of MeOH, ethanol, and pyrazole derivatives were. Conclusion: This study demonstrated that CAPE treatment decreased the oxidative stress in acute MeOH intoxication in the retina and optic nerve; beside that, protected RGC layer histology. In silico, CAPE had higher affinity score than MeOH, ethanol, pyrazole and pyrazole derivatives in the case of interaction with alcohol dehydrogenase.Öğe Effects of smoking on visual acuity of central serous chorioretinopathy patients(Informa Healthcare, 2014) Turkcu, Fatih Mehmet; Yuksel, Harun; Sahin, Alparslan; Cinar, Yasin; Cingu, Kursat; Ari, Seyhmus; Sahin, MuhammedBackground: The aim of this study was to evaluate the differences, in terms of visual outcome and treatment needs, between smokers and non-smokers central serous chorioretinopathy (CSCR) patients. Methods: The files of 252 patients diagnosed with CSCR who had presented to the Retina Unit of the Ophthalmology Clinic at Dicle University Medical School in Turkey were retrospectively evaluated. Eighty-four smokers, with a known history of smoking of at least one pack-year, and 133 non-smokers were included, whereas 35 patients with additional pathologies were excluded from the study. Results: Of the patients, 192 (88.5%) were male and 25 (11.5%) were female. The mean patient age was 38.8 +/- 8.1 years (range: 20-68 years). Visual acuity (VA) of the smoker and non-smoker groups was measured as 0.45 +/- 0.35 and 0.24 +/- 0.28 logarithm of the minimum angle of resolution (logMar), respectively, at the first visit; 0.19 +/- 0.29 and 0.06 +/- 0.14 logMar at the sixth month; and 0.07 +/- 0.14 and 0.02 +/- 0.05 logMar at the ninth month. VA measurements at presentation and during all examinations (1th, 6th and 9th month) were significantly different for the two groups. VA was lower in the smoker group. In 27 patients (12.4%), an additional treatment modality was needed. Of the 27 patients, only 8 (6%) were non-smokers, whereas 19 (22.6%) were smokers. There was no difference between groups in the recurrence rate during follow-up (p = 0.907); 14 (16.7%) smokers and 8 (19.0%) non-smokers experienced a recurrence. Conclusion: This study has shown that patients selected and who are current smokers have poorer vision and need longer treatment.Öğe Effects of vernal and allergic conjunctivitis on severity of keratoconus(Ijo Press, 2013) Cingu, Abdullah Kursat; Cinar, Yasin; Turkcu, Fatih Mehmet; Sahin, Alparslan; Ari, Seyhmus; Yuksel, Harun; Sahin, MuhammedAIM: To demonstrate the effects of two different types of allergic conjunctivitis on severity of keratoconus (KC). METHODS: We retrospectively reviewed the medical records of 171 KC patients referred between June 2010 and June 2011. The KC patients were divided into 3 groups as KC (group A), KC with vernal keratoconjunctivitis (VKC) (group B) and KC with allergic conjunctivitis (AC) (group C). Main outcome measures were demographic and ocular clinical features including age at presentation, gender, spherical equivalent (SE), best spectacle corrected visual acuity (BCVA), mean keratometric measurement (Km), central corneal thickness (CCT), and intraocular pressure (IOP). Groups were compared in term of study variables. RESULTS: The median age at presentation was significantly lower in group B (P<0.001). According to the median SE (P=0.003), BCVA(P=0.022), Km(P<0.001), CCT (P=0.015) and Amsler-Krumeich classification (P< 0.001), KC was more severe in group B. There was no significant difference in terms of IOP and corrected IOP among the groups (P=0.44), however there were 4 patients who had increased corrected IOP developed after topical corticosteroid use in group B. The differences among the groups persisted even after controlling for age and gender. CONCLUSION: Our findings demonstrated a more severe KC in VKC patients despite their younger age which suggests evaluation of VKC patients as a separate group in keratoconus disease.
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