Yazar "Turkcu, Fatih M." seçeneğine göre listele

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    Anterior segment parameters of rabbits with rotating Scheimpflug camera
    (Wiley-Blackwell, 2015) Yuksel, Harun; Turkcu, Fatih M.; Ari, Seyhmus; Cinar, Yasin; Cingu, Abdullah K.; Sahin, Muhammed; Sahin, Alparslan
    BackgroundRabbit is one of the most commonly used experimental animals for corneal studies due to similarity of size to human cornea and ease of manipulation. In this study, we assessed anterior segment parameters of the healthy rabbit eyes with Pentacam HR (Oculus, Wetzlar, Germany). MethodsSix-month-old, approximately 2.5-3kg weighted, 30 female New Zealand rabbits were used in the study. Right eye of the each rabbit was imaged with Pentacam HR under intramuscular ketamine hydrochloride (Ketalar; Eczacibasi, Turkey) anesthesia (50mg/kg). After the imaging, the rabbits with blinking errors, which results in low-quality images, were excluded from the study. Keratometric readings, central corneal thickness (CCT), anterior chamber depth (ACD), and anterior and posterior elevation values, and lens density were noted. ResultsIn this study, the flattest and the steepest keratometric values were found as 43.341.86, 42.7 +/- 2.0, and 43.9 +/- 1.9diopters, respectively. The mean CCT and ACD of rabbits were found as 388 +/- 39m and 2.08 +/- 0.16mm, respectively. Mean of the anterior and posterior elevation at thinnest point was found as 1.29 +/- 4.28 and 3.91 +/- 6.17m, respectively. ConclusionsKeratometric readings and anterior and posterior elevation values of rabbits were similar to human; however, corneal thickness and anterior chamber depth (ACD) values were lower than humans.
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    Effect of Estrogen Replacement Treatment on VEGF in Serum and Retina in Rats
    (Modestum Ltd, 2015) Yuksel, Harun; Turgut, Fethiye Gulden; Turkcu, Fatih M.; Ozkurt, Zeynep; Sahin, Muhammed; Yuksel, Hatice; Turkcu, Gul
    Vascular endothelial growth factor (VEGF) is a molecule implicated in the pathogenesis of several eye diseases. In this experimental study, we planned to evaluate the effects of surgical menopause and hormone replacement therapy on VEGF levels. Thus, we studied the effects of treatments involving estrogen, estrogen and progesterone (E/P) in combination, and genistein, which is a selective estrogen modulator, on serum VEGF levels and the expression of VEGF in the retinas of rats with surgical menopause. The rats were randomly divided into five groups. Bilateral ovariectomy (OVX) was performed in all groups except for the sham-operated group. estrogen, E/P, genistein or water (sham and control groups) treatments were given for 8 weeks through the orogastric catheter. Serum VEGF level and immunohistochemical staining of VEGF in retinal tissue were analyzed in each group. Serum VEGF levels were significantly higher in the OVX + estrogen and OVX + genistein groups than in the control and sham groups. It was also higher in the OVX + E/P group than in the sham and control groups; however, in this case, the difference was not statistically significant. The OVX + estrogen, OVX + E/P, and OVX + genistein groups exhibited increased VEGF staining in comparison with the control and sham groups. However, the difference was not statistically significant. The current study demonstrated that estrogen replacement treatment (ERT) leads to an increase in serum VEGF levels and progesterone plays a protective role in this increase. The ERT used in this study had no effect on VEGF expression in the retina.
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    The effects of delivery type and gender on intraocular pressure and central corneal thickness in newborns
    (Consel Brasil Oftalmologia, 2016) Ozkurt, Zeynep Gursel; Balsak, Selahattin; Balsak, Berrin; Guclu, Hande; Sahin, Muhammed; Yuksel, Harun; Turkcu, Fatih M.
    Purpose: To analyze intraocular pressure (IOP) and central corneal thickness (CCT) in newborns during the first 12 h of life. Methods: Forty-three newborns born by vaginal delivery (VD) and 30 newborns born by cesarean section (CS) were evaluated. IOP and CCT were measured using Tono-Pen and handheld pachymeter, respectively, at both the 5th minute after delivery and at the 12th h of life. Results: The mean IOP for the VD group was significantly higher than that of the CS group at both the 5th minute and 12th h (p=0.042 and p=0.018, respectively). In both groups, the IOP decreased by the 12th h, but the decrease was only significant for the CS group (p=0.020). The decrease in CCT over the 12 h was significant for both groups (p<0.001). In the VD and CS groups, the IOP values of the males were significantly higher than those of the females at the fifth minute only (p=0.024 and p=0.043, respectively). No other values were significantly different between the genders. Conclusions: Newborn IOP is affected by the mode of delivery and gender. A higher IOP was found in vaginally delivered newborns than in CS newborns for at least 12 h postpartum. CCT showed a significant decline within 12 h. Male newborns have significantly higher IOP values in the first minutes of life.
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    Inner and outer segment junction (IS/OS line) integrity in ocular Behcet's disease
    (Consel Brasil Oftalmologia, 2014) Yuksel, Harun; Turkcu, Fatih M.; Sahin, Muhammed; Cinar, Yasin; Cingu, Abdullah K.; Ozkurt, Zeynep; Sahin, Alparslan
    Purpose: In this study, we examined the spectral domain optical coherence tomography (OCT) findings of ocular Behcet's disease (OB) in patients with inactive uveitis. Specifically, we analyzed the inner and outer segment junction (IS/OS line) integrity and the effect of disturbed IS/OS line integrity on visual acuity. Methods: Patient files and OCT images of OB patients who had been followed-up between January and June of the year 2013 at the Dicle University Eye Clinic were evaluated retrospectively. Sixty-six eyes of 39 patients were included the study. Results: OCT examination of the patients with inactive OB revealed that approximately 25% of the patients had disturbed IS/OS and external limiting membrane (EML) line integrity, lower visual acuity (VA), and lower macular thickness than others. Linear regression analysis revealed that macular thickness was not an independent variable for VA. In contrast, the IS/OS line integrity was an independent variable for VA in inactive OB patients. Conclusion: In this study, we showed that the IS/OS line integrity was an independent variable for VA in inactive OB patients. Further prospective studies are needed to evaluate the integrity of the IS/OS line in OB patients.
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    One year results of anti-VEGF treatment in pigment epithelial detachment secondary to macular degeneration
    (Consel Brasil Oftalmologia, 2013) Yuksel, Harun; Turkcu, Fatih M.; Sahin, Alparslan; Sahin, Muhammed; Cinar, Yasin; Cingu, Abdullah K.; Ari, Seyhmus
    Purpose: Pigment epithelial detachment (PED) may be seen in all stages of age-related macular degeneration (ARMD) and may lead to poor prognosis. In this study, we retrospectively examined the effect of anti-VEGF treatments in ARMD patients with vascularized PED. Methods: Medical records of 15 patients with PED secondary to ARMD were re--viewed retrospectively. The diagnosis of PED was made with fundoscopy, fundus fluorescein angiography and optical coherence tomography. Patients were treated with intravitreal ranibizumab or/and bevacizumab and followed up for a minimum of one year. PED height and best corrected visual acuity (BCVA) was obtained before the first intravitreal anti-VEGF injection and again at the 1st, 3rd, 6th and 12th month after the injection. Results: The mean baseline BCVA was 0.71 +/- 0.48 logarithm of the minimal angle of resolution (logMAR) unit and the mean baseline PED height was 361 +/- 153 mu. The mean injection count per eye was 3.9 +/- 2.9. There was a significant reduce in mean PED height (247 +/- 177 mu) also in 2 eyes PED completely resolved at the end of the follow up period. The mean BCVA at 12th month (0,69 +/- 0,37) were not different from the baseline record. Conclusions: This retrospective case series showed that intravitreal anti-VEGF therapy preserved vision and reduced PED height in PED patients in a one-year follow-up period.
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    Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-? Production in PBMC of Patients with Behcet's Disease
    (Hindawi Ltd, 2016) Irtegun, Sevgi; Pektanc, Gulsum; Akkurt, Zeynep M.; Bozkurt, Mehtap; Turkcu, Fatih M.; Kalkanli-Tas, Sevgi
    Behcet's disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-alpha production in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment.
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    Retinopathy of prematurity screening with mobile phones
    (Wichtig Publishing, 2016) Sahin, Alparslan; Turkcu, Fatih M.; Yildirim, Adnan
    [Abstract Not Available]
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    Vision-related quality of life in patients after ocular penetrating injuries
    (Consel Brasil Oftalmologia, 2014) Yuksel, Harun; Turkcu, Fatih M.; Sahin, Muhammed; Cinar, Yasin; Cingu, Abdullah K.; Ozkurt, Zeynep; Bez, Yasin
    Purpose: To measure and investigate visual functioning and health-related quality of life (QOL) in patients after ocular penetrating injuries (OPI). Methods: Fifty-four adult patients with OPI and 26 healthy control subjects were enrolled in the study. The National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) and the 36-Item Short Form Health Survey (SF 36) were administered. Sociodemographic and clinical data also were collected. The primary outcome measures were comparisons and multivariate analysis among groups for the NEI VFQ-25 and SF 36 subscale scores. Results: All NEI VFQ-25 scores, except general health, were significantly lower in the OPI group than those in the control group. All SF 36 scores were significantly lower in the OPI group than in the control group. The NEI VFQ-25 subscale item scores showed no significant differences with respect to age, educational level, or visual acuity in the injured eye. The SF 36 subscale item scores revealed no significant differences according to gender or educational level. Conclusions: Patients with OPI have increased psychological symptoms and lower levels of QOL than healthy control subjects have. Deteriorations in QOL should be kept in mind when managing patients with OPI.