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    The combined effect of rosuvastatin and ischemic pre- or post-conditioning on myocardial ischemia-reperfusion injury in rat heart
    (Verduci Publisher, 2015) Kelle, I.; Akkoc, H.; Uyar, E.; Erdinc, M.; Evliyaoglu, O.; Saribas, S.; Tunik, S.
    OBJECTIVE: To investigate the combined effect of rosuvastatin and ischemic preconditioning or postconditioning on ischemia-reperfusion injury in in vivo rat heart. MATERIALS AND METHODS: Ninenty-six male adult Wistar rats were randomly assigned to eight groups: Sham group, ischemia-reperfusion, rosuvastatin preconditioning, rosuvastatin postconditioning, ischemic preconditioning, ischemic postconditioning, ischemic + pharmacologic preconditioning and ischemic + pharmacologic postconditioning groups. Blood samples were taken for creatine kinase evaluation at selected time points. Six rats in each group were separated for either infarct size assessment or immunohistochemical staining with Bcl-2 antibody. RESULTS: The staining with Bcl-2 was significantly lower in groups Sham, ischemic + pharmacologic preconditioning and ischemic + pharmacologic postconditioning groups which is well correlated with the decrease in infarct size for the same groups. The creatine kinase enzyme levels were also reduced to their lowest levels in ischemic + pharmacologic preconditioning and ischemic + pharmacologic postconditioning groups. CONCLUSIONS: These findings suggest that enriching the composition of reperfusate with rosuvastatin along with ischemic preconditioning or postconditioning procedures at the opposite sides of ischemia may interact synergistically for protecting ischemic myocardium from reperfusion injury. The combined application of rosuvastatin with ischemic preconditioning or ischemic postconditioning may provide a new therapeutic option in clinical interventions when compared to single treatment with ischemic and rosuvastatin preconditioning or postconditioning.
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    EFFECTS OF ETHYL PYRUVATE ON TESTICULAR DAMAGE IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES
    (Editura Acad Romane, 2012) Akkoc, H.; Kelle, I.; Tunik, S.; Erdinc, M.; Erdinc, L.; Nergiz, Y.
    Diabetes mellitus is associated with impairment of testicular functions. Aim. The present study aimed to investigate the effects of ethyl pyruvate (EP) on the testicular tissue damage in rats with streptozotocin (STZ)-induced diabetes. Subjects and methods. Thirty-two Wistar albino male rats were assigned into four equal groups as follows: (1) control group (n:8); (2) EP-treated non-diabetic group (n:8); (3) diabetic group (n:8); and (4) EP-treated diabetic group (n:8). Rats with STZ-induced diabetes were kept alive for 14 weeks. After that, the EP solution was administered intraperitoneally to the rats in the EP-treated non-diabetic and diabetic groups at the dose of 50 mg/kg twice daily for 14 clays. At the end of this period, the left testes were removed from the rats for malondialdehyde (MDA) analysis, and the right testes were removed for histological examination. Results. As compared with the control group, the diabetic group had elevated MDA levels (210.9 +/- 12.7) and increased thickness of the basement membrane of the seminiferous tubules (3.01 +/- 0.16), but decreased tubular diameter (159 +/- 9.0) and Johnsen's score (5.31 +/- 0.1). In the EP-treated diabetic group, diabetes-induced impairment was significantly improved. Conclusion. These findings indicate that EP shows protective effects against diabetes-induced testicular dysfunction.
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    The Efficacy of Tarantula cubensis Extract (Theranekron) in Treatment of Canine Oral Papillomatosis
    (Academic Journals Inc, 2011) Icen, H.; Sekin, S.; Simsek, A.; Kochan, A.; Tunik, S.
    The aim of this study was to investigate the effects of Tarantula cubensis extract (Theranekron, Richter Pharma, Austria) applied on canine oral papillomatosis. A total of 10 dogs brought from dogs shelter to the Faculty of Veterinary Medicine, University of Dicle Turkey and aged between 7 and 36 months were used in this study. Diagnosis of the papillomatosis was based on clinical signs and histopathological examinations. Each dog received 2 mL per 10 kg of Tarantula cubensis extract subcutaneously two times per week. Regression of papillomas was observed after the beginning of treatment in second week. At the end of the third week 7 dogs recovered. The treatment continued on 3 dogs for two more weeks after which there was complete resolution of the lesion. Tarantula cubensis extract applications therefore seemed to be effective in the treatment of canine oral papillomatosis.
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    The histological study of osseous regeneration following implantation of various bone graft biomaterials
    (Wolters Kluwer Medknow Publications, 2016) Alan, H.; Farahani, E. M. Z.; Tunik, S.; Kavak, G.
    Background: While various biomaterials are used for bone regeneration, the relative comparative efficiency of them has not been thoroughly investigated. Purpose: This study evaluated histopathological events during osseous healing after implantation of following bone grafts: Demineralized freeze-dried cortical bone powder (DFDB), natural coral implants, calcium sulfate-based putty containing demineralized bone matrix (CaS-DBM), and pure-phase beta tricalcium phosphate ceramic granules (-TCP). Materials and Methods: Fifty-six Wistar Albino rats were used for this study. The postimplantation osseous healing was evaluated at 3(rd), 6(th) weeks after the operation. Results: DFDB did not induce bone formation in 3 weeks period, but it showed a highly osteoinductive effect at the end of 6(th) week period. The effects of coral implants on bone formation both at 3 and 6 weeks period were much higher than the DFDB. CaS-DBM showed higher bone formation than -TCP at 3(rd), 6(th) weeks. It was found that coral and CaS-DBM had a more beneficial impact on early bone healing compared to -TCP and DFDB. All these graft biomaterials are useable in human bone defects. The main difference in the ossous healing properties of these materials is observed early postimplantation with the delayed healing outcome being similar.
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    Mapping angiogenesis on choroidal membranes of a murine laser-induced CNV model
    (Wiley-Blackwell, 2014) Tunik, S.; Aronsson, M.; Kvanta, A.; Andre, H.
    [Abstract Not Available]
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    Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats
    (Univ Catholique Louvain-Ucl, 2012) Akkoc, H.; Kelle, I.; Tunik, S.; Bahceci, S.; Sencar, L.; Ayaz, E.; Nergiz, Y.
    Background and aims : Diabetes Mellitus, leading to an increase in oxidative stress, can cause liver damage. Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats. Materials and methods : Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows : (1) Non-diabetic group; (2) EP-treated non-diabetic group; (3) diabetic group; and (4) EP-treated diabetic group. In order to induce diabetes mellitus, 45 mg/kg b.w. streptozotocin was administered intraperitoneally to the rats in groups 3 and 4. On the 3rd day, blood glucose was assessed. Rats with blood glucose levels higher than 300 mg/dl were considered to be diabetic. The EP solution was administered intraperitoneally at a dose of 50 mg/kg b.w. twice daily for 14 days to the rats in groups 2 and 4. The other rats were simultaneously given the same amount of Ringer's lactate solution intraperitoneally. Liver tissue was obtained for malondialdehyde (MDA) analyses and histopathological examination. Results : In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4. Conclusions : These findings show that EP has protective effects against diabetes-induced liver injury. (Acta gastroenterol. belg, 2012. 75, 336-341).
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    Ultrastructural Changes in the Kidney Cortex of Rats Treated with Lead Acetate
    (Soc Chilena Anatomia, 2011) Deveci, E.; Soker, S.; Baran, O.; Tunik, S.; Ayaz, E.; Deveci, S.
    The purpose of this study was to investigate the ultrastructural effects of lead on the kidney cortex of rats. Wistar Albino rats (180-200g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were taken from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. The kidney tissue samples were prepared and analyzed by light and transmission electron microscopy. Cortical renal tubules show various degenerative changes with focal tubular necrosis invaded by inflammatory cells. The ultrastructural alterations found in lead acetate-treated rats were a diminution in the amount of filtration slits, increased fusion of foot processes in epithelial cells of the glomeruli, increase of lysosomal structures and pinocytic vesicles as well as large mitochondria in proximal tubule cells.