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Öğe Atorvastatin Has no Effects on Kidney Tissues of Wistar Albino Rats in the Long-Term Intake: An Electron Microscopic Study(Soc Chilena Anatomia, 2011) Aktas, Ayfer; Tasdemir, M. Serhan; Tuncer, M. Cudi; Nergiz, Yusuf; Akkus, Murat; Bagriyanik, Husnu AlperIn this study, we evaluated the ultrastructural findings of kidney with systemic administration of different doses of atorvastatin in a rat model. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage. The aim of this study was to investigate how atorvastatin could play a role in kidney tissues. Forty adult male Wistar albino rats (200-250 g) were randomly divided into 4 groups of ten rats each (A1, A2, A3 and Control). Three different doses of atorvastatin were used to determine the effects on kidney tissues during 90 day period. The kidneys of A1 (0.1-mg group), A2 (0.5-mg group) and A3 (1-mg group) group were excised and the tissues were examined after the 90 days by transmission electron microscopy. Despite increasing the dose of atorvastatin intake, the histological structures of atorvastatin groups were appeared normal in the same period. In conclusion, long-term use of atorvastatin was not found to have an adverse effect on kidney tissue.Öğe Coexisting of aortic arch variation of the left common carotid artery arising from brachiocephalic trunk and absence of the main branches of right subclavian artery: a review of the literature(Editura Acad Romane, 2010) Karabulut, Ozlen; Iltimur, Kenan; Tuncer, M. CudiThe variations in the aortic arch and its branches are of surgical interest. Many anomalies of the aortic arch and great vessels are uncovered as serendipitous findings on imaging studies, in the anatomy laboratory, or at surgery. A 56-year-old woman had an arch angiogram as part of an evaluation for cardiovascular disease. A two-vessel left aortic arch was identified consisting of the brachiocephalic trunk and left subclavian artery. In this study, we present a case of the left common carotid (LCC) artery arising from the brachiocephalic trunk (BT) and absence of the main branches of right subclavian artery in her angiographic imaging findings. There is no previous report about LCC artery arising from BT and absence of the main branches of right subclavian artery in the same person.Öğe The demonstration of the inferior sternal cleft using three-dimensional reconstruction: a case report(Editura Acad Romane, 2009) Tuncer, M. Cudi; Aluclu, M. Ufuk; Karabulut, Oezlen; Ulku, Refik; Hatipoglu, E. Savas; Nazaroglu, HasanCongenital sternal cleft is a rare disorder in which there is a gap in the midline of the anterior chest wall between the two halves of the sternum. Typically, the contour of the mediastinal structures can be seen beneath the skin. It is rare and the exact incidence is not known. It results from failure of fusion of the two lateral mesodermal sternal bars by 8 weeks of gestation. Most cases are diagnosed shortly after birth and are reported only rarely in adults. We report here one of the congenital major chest wall deformities; inferior sternal cleft is rarely seen, associated with sternal and costal variations in a 22-year young man.Öğe Deneysel Tavmatik Omurilik Hasarında Thymbra Spicata L. var Spicata ve Cyclotrichium Origanifolium’un Mesane Üzerine Koruyucu Etkisinin Araştırılması(Akdeniz Üniversitesi, 2025) Direk, Figen Koç; Durmaz, Sevda Canbay; Tuncer, M. Cudi; Karabaş, Sibel Ateşoğlu; Keşim, Dilek Aygün; Nas, Cemal; Deveci, EnginÖZ Amaç: Spinal kord yaralanmaları, genellikle travma sonrası vertebral kolonda meydana gelen kırıklar, çıkıklar, bağ yaralanmaları ve yırtılmalar sonucunda oluşan hasarları kapsamaktadır. Bu yaralanmalarda komplikasyonların en sık görüldüğü organlardan biri mesanedir. Thymbra spicata L. var spicata (zahter) ve Cyclotrichium origanifolium (dağ nanesi) bitkilerinin yüksek biyolojik potansiyele sahip olduğu; ekstraktlarının antioksidan özellikleri sayesinde oksidatif stresin neden olduğu hastalık riskini azalttığı ve tedavide önemli bir rol oynadığı bilinmektedir. Bu çalışmada, zahter ve dağ nanesi ekstraktlarının spinal kord yaralanması sonrası mesane disfonksiyonları üzerindeki potansiyel tedavi edici ve koruyucu etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Çalışmada, ağırlıkları 250-300 g arasında değişen toplam 36 adet Wistar Albino erkek sıçan, her grupta altı sıçan olacak şekilde altı gruba ayrılmıştır: Grup 1 (kontrol), Grup 2 (zahter), Grup 3 (dağ nanesi), Grup 4 (travma), Grup 5 (travma + zahter), Grup 6 (travma + dağ nanesi). Travma gruplarında omuriliğe ağırlık düşürme yöntemi uygulanarak travma modeli oluşturulmuştur. Bir haftasının sonunda, tüm sıçanlardan idrar örnekleri alındıktan sonra, ketamin anestezisi altında sakrifiye edilerek mesane dokuları alınmıştır. Mesane dokularında histopatolojik değişiklikler incelenmiştir. Bulgular: Deneysel araştırma sonucunda, zahter ve dağ nanesi ekstraktlarının spinal kord yaralanmasına bağlı gelişen mesane hasarına karşı kısmen etkili olduğu saptanmıştır. Zahterin etkinliğinin, biyokimyasal ve histopatolojik bulgular doğrultusunda, oksidatif stres ve inflamatuar belirteçler üzerindeki etkisinin dağ nanesine kıyasla daha yüksek olduğu gözlemlenmiştir. Sonuç: Sonuç olarak, deneysel modellerin artmasıyla birlikte bitki ekstraktlarının tedavi amaçlı kullanımının yaygınlaşabileceği ve insan sağlığı üzerinde olumlu etkiler sağlayabileceği düşünülmektedir.Öğe Effects of Curcumin and Doxorubicin on the Viability of Neuroblastoma Cancer Cell Line(Merthan TUNAY, 2024) Ünlü, İlker; Özdemir, İlhan; Öztürk, Şamil; Tuncer, M. CudiAim: Neuroblastoma has a very important place among childhood diseases, and despite all the methods used in treatment, it is very difficult to prevent neuroblastoma invasion. The number of studies showing that curcumin, the most active component of turmeric, is not toxic, is increasing day by day. In this study, the anticancer activities of curcumin (Cur), one of the important active compounds, were demonstrated in the Neuroblastoma cancer cell line (Na2B). Method: Neuroblastoma cell line was used in the study. To determine the IC50 doses of Dox and Cur, Na2B cells line were cultivated with an automatic pipette. MTT analysis was performed to analyze cell survival (viability). Inhibition levels in the cells were determined at 24 and 48 hours. Results: While the IC50 of Na2B cell proliferation was approximately 124.5 uM at the 48th hour in Dox-treated cells, the IC50 value of Cur at the 48th hour was found to be 224.6 uM. Conclusion: These results showed that Cur could be an alternative agent in the treatment of neuroblastoma, and its fewer side effects compared to other chemotherapeutic agents such as Dox would increase its preferability.Öğe Left Ventricular Mass in Normal Children and its Correlation with Weight, Height and Body Surface Area(Soc Chilena Anatomia, 2011) Kervancioglu, Piraye; Kervancioglu, Mehmet; Tuncer, M. Cudi; Hatipoglu, E. SavasEchocardiographic measurement of left ventricular mass (LVM) is being used for the diagnosis of left ventricular hypertrophy in children with various cardiovascular diseases. The purposes of this study was to establish normal values of LVM according to weight, height and body surface area (BSA) in children and to determine the sex differences. We evaluated 208 children (143 males and 65 females), aged 1 day to 14 years who had no cardiovascular disease. The end-diastolic left ventricular internal dimension (LVIDd), end-diastolic left ventricular posterior wall thickness (LVPWd) and end-diastolic interventricular septum (IVSd) values were determined by M-mode echocardiographic examination. By using these values, left ventricular mass was calculated. The difference between LVIDd, LVPWd and LVM values of boys and girls were not statistically significant. We observed statistically significant differences between the sexes relative to IVSd and LVM/BSA values. The left ventricular mass and its components presented a good correlation with age, weight, height and BSA. The study let us know the lower and upper limits of cardiac dimensions and LVM obtained by echocardiography in normal Turkish children according to BSA. Also, as the LVM/BSA values show gender difference in children, sex should be taken in consideration while evaluating the left ventricular hypertrophy.Öğe Protective Effects of Melatonin on Testicular Torsion and Detorsion Damage in Sprague-Dawley Rats(Soc Chilena Anatomia, 2011) Aktas, Ayfer; Tuncer, M. Cudi; Yildirim, Ayse; Nergiz, Yusuf; Akkus, MuratIn this study, we evaluated the ultrastructural findings of testis with systemic administration of different doses of melatonin during ischemic period in a rat model of testicular torsion/detorsion (T/D). Testis ischemia-reperfusion (I/R) injury was induced by torsion of the left testis, with a 720 degrees twisting of the spermatic cord so as to produce a total occlusion of testis for 2.5 hours. Subsequently, the same testis was then detorsioned. According to surgical procedure in each group, unilateral orchiectomies were performed for histopathologic examination. The groups were labelled as control group, torsion group (T), torsion and detorsion group (T/D), torsion-detorsion and melatonin group (T/D+20,50 and 100 mg/kg melatonin). For the histological examination, testicular tissues were fixed in 2.5% glutheraldehyde and postfixation 1% osmic acid solutions. They were examined under transmission electron microscopy after application of contrast stained. In torsion group testis cross-sections, cytoplasm residues of mature sperms and large vacuole-like structures were noticeable. In detorsion group testis cross-sections, dissociations in spermatocide nuclei, many vacuoles and residual particles resulting from organelle degeneration, local voids in cytoplasms of spermatogonia, dilatation in granulated endoplasmic reticulum, large lipid droplets, chromatid particles, along with mitochondrial crystalisis were determined. In the testis cross-sections of the group of T/D+50 mg/kg melatonin administration, sertoli and spermatogonia cells that showed membrane-like structures and cytoplasmic voids were observed. Testis cross-sections of rats that were administered with T/D+50 mg/kg melatonin showed small mitochondrions and vacuole-like structures placed on the edge. Testis cross-sections of rats that were administered with T/D+100 mg/kg melatonin resulted in views similar to those of controls in the microstructural level. As a result, the most effective dose of melatonin, which was used in different doses, for prevention of ischemia/reperfusion damage was found to be 100 mg/kg.Öğe Psöriasis vulgaris'li hastalarda tedavi öncesi ve sonrası deri kan akımı değişikliklerinin Xenon-133 ile değerlendirilmesi(1998) Şendur, Neslihan; Harman, Mehmet; Tuncer, M. Cudi; Gezici, Ayten; Kara, AhmetBu çalışmada psöriasis vulgarisli hastalarda tedavinin deri kan akımı üzerine olan etkisini araştırmayı amaçladık. Çalışmaya kortikosteroid tedavisi öncesi ve tedavi sonrası psöriasis vulgarisli 10 hasta ve 7 tane normal kontrol alındı. Hasta grubunda deri kan akımı ölçümü tedavi öncesi ve sonrası olmak üzere iki aşamada yapıldı. Xenon-133'ün intradermal verilmesini takiben 20 dakika süreyle psöriatik deri, simetrik lezyonsuz deri ve normal kontrol grubu deri görüntüleri toplandı. Psöriatik deri, simetrik lezyonsuz deri ve kontrol deriye ait Xenon-133' ün deriden kayboluşuna ait zaman aktivite eğrisi çizilerek deri kan akımı Kety-Schmidt metodu kullanılarak kantitatif olarak hesaplandı.Sonuçlar istatistiksel olarak analiz edildi. Tedavi öncesi lezyonlu deri kan akımı, lezyonsuz ve normal deri kan akımı değerlerine göre önemli derecede farklı bulundu (p<0.01 ve p<0.01). Lezyonsuz psöriatik deri ile normal deri değerleri karşılaştırıldığında ise aradaki farkın önemsiz olduğu görüldü (p>0.05). Klinik olarak iyileşme izlenen psöriatik derinin tedavi öncesi ve sonrası kan akımı değerleri karşılaştırıldığında aradaki farkın anlamlı olduğu görüldü (p<0.01). Psöriatik deri kan akımı değerleri lezyonsuz deri ve normal grup kan akımı değerleri ile karşılaştırıldığında aradaki fark anlamlı bulundu (p<0.01 ve p<0.01). Lezyonsuz simetrik deri ile normal grup deri kan akımı değerleri karşılaştırıldığında ise aralarındaki farkın önemsiz olduğu bulundu (p>0.05).Öğe VARIATONS OF PROPER HEPATIC ARTERY(Wiley, 2017) Ulger, Burak Veli; Hatipoglu, E. Savas; Hamidi, M. Cihad; Tuncer, M. Cudi[Abstract Not Available]
