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Öğe Attitudes toward and exposure to gender discrimination in work life by pulmonologists and thoracic surgeons: a questionnaire-based survey among Turkish thoracic society members(Frontiers Media Sa, 2024) Ocakli, Birsen; Yorgancioglu, Arzu; Gungor, Sinem; Topcu, Fusun; Senol, Yesim Yigiter; Goktas, Basak; Kokturk, NurdanBackground: This study aimed to evaluate attitudes toward and exposure to gender discrimination in work life by chest diseases specialists and thoracic surgeons. Methods: A total of 275 members of Turkish Thoracic Society (TTS) were included on a voluntary basis in this online cross-sectional questionnaire-survey using an internal member-only social media platform of TTS. The questionnaire form elicited items on sociodemographic characteristics, occupational characteristics and gender discrimination in work life (general opinions, attitudes and exposure). Results: Female doctors (vs. males) were less likely to be a thoracic surgeon (13.8% vs. 34.5%, p < 0.05) and a professor of thoracic surgery (0.0% vs. 26.7% vs. p < 0.05), and more likely to consider housework as a considerable burden (89.8 vs. 73.6%, p = 0.02) and the significant role of discriminatory, negative and dissuasive attitudes of male physicians in their career choice (67.6 vs. 35.6%, p = 0.039). Male doctors were more likely to considered that men are more successful in specialties that require active physical strength (65.5 vs. 27.7%, p = 0.005) and those with very long working hours and heavy shifts (57.5 vs. 39.4%, p = 0.001). Female thoracic surgeons were more likely than males to consider that specialties with very long working hours and heavy shifts are more suitable for men (26.9 vs. 6.0%, p = 0.027) and men are given priority in academic career promotion (64.0 vs. 13.3%, p < 0.001). Younger (vs. older) females reported higher rate of exposure to gender discrimination (p = 0.041) and considerable impact of social roles on the specialty (p = 0.007), while female doctors working as a resident (33.8%) and a specialist (50.05%) indicated higher rate of exposure to gender discrimination during their career (p = 0.024). Conclusion: In conclusion, our findings revealed that exposure to gender discrimination in work life was more commonly expressed by female members of TTS, particularly in terms of burden of social roles, career advancement options and leadership positions, along with significant role of discriminatory, negative and dissuasive attitudes of male physicians in their career choice. Accordingly, women remain underrepresented in thoracic surgery, particularly in the academic rank of full professor and in leadership positions with inability to promote after a definite step in their careers.Öğe A Case of Lymphocytic Interstitial Pneumonitis Associated With Sjgren's Syndrome With Atypical Radiological Findings(Bilimsel Tip Publishing House, 2008) Yildiz, Tekin; Akyildiz, Levent; Topcu, Fusun; Yilmaz, FahriThe 42 year old female patient admitted to our hospital with the compliants of cough, sputum, loss of weight, hoarseness and dryness of the eyes and skin. On the chest x-ray, opacification was found in the right lower zone. The chest CT scan demonstrated nodular lesions, including air bronchograms showing a partial alveolar pattern in the middle and lower right lobes and bilateral pleural plaques. The diagnosis of Sjogren's Syndrome was made on the basis of bilateral Schirmer test positivity in the ophthalmologic examination and anti-SSA: (+++) positivity, with a titration of 1/100. The cytologic examination of bronchoalveolar lavage fluid and histopathological evaluation of transbronchial biopsy were not diagnostic. Lymphocytic interstitial pneumonia was diagnosed by evaluation of a transthoracic fine needle biopsy (tru cut). In this case report, we present a case of lymphocytic interstitial pneumonia associated with Sjogren's syndrome with atypical radiological findings, who responded favourably to steroid and cyclophosphamide treatment.Öğe Determination of Attitudes of Turkish Thoracic Society Members on Exposure to Sexist Approach and Sexism in Business Life(European Respiratory Soc Journals Ltd, 2018) Ocakli, Birsen; Yorgancioglu, Arzu; Topcu, Fusun; Kokturk, Nurdan; Altinoz, Hilal; Yasin, Yesim; Kuzuca, Ilknur Genc[Abstract Not Available]Öğe Effect of passive smoking on the development of chronic obstructive pulmonary disease in southeastern Turkey(Tubitak Scientific & Technological Research Council Turkey, 2010) Yildiz, Tekin; Topcu, Fusun; Celik, Lisa; Akyildiz, Levent; Ates, Gungor; Durak, DilekAim: To determine the effect of passive smoking on the development of chronic obstructive pulmonary disease (COPD) among persons who spend a long time in cafes Materials and methods: The study sample included 348 male smokers who were older than 40 years and spend a long time in cafes The questions were derived from the European Coal and Steel Community (ECSC) questionnaire We also inquired about the nature of cafe visits (hours/day, visits/week, visits/month) Results: COPD was found in 18 1% (63/348 subjects) of the smokers aged >= 40 years In these 63 subjects, based on spirometry results, the rate of mild and moderate airflow limitation was 23 8% (15/63) and 76 2% (48/63), respectively Of the 63, 60 (95%) had no previous diagnosis of COPD After we had accounted for known risk factors for the development COPD, we identified new risk factors, time spent in cafes (hours/day), the number of cafe visits per week (visits/week), and the number of cafe visits per month (visits/month), which had higher odds ratios for smokers without COPD (5 376, 2 721, and 2 337, respectively) Conclusion: Spending time in cafes regularly may contribute as an additional risk factor for the development of the COPDÖğe Effects of Atorvastatin on Smoking-Induced Alveolar Injury in Rat Lungs(Elsevier, 2009) Yildiz, Tekin; Tasdemir, Serhan; Tunik, Selcuk; Ates, Gungor; Tekes, Selahaddin; Kaplanoglu, Iskender; Topcu, FusunBACKGROUND: Smoking is one of the most serious health care issues worldwide, as one third to one half of all people who smoke eventually use tobacco habitually. Chronic smoke exposure causes airway and lung parenchymal inflammation and the destruction of alveolar cell walls. Statins may have anti-inflammatory effects that would play a role in preventing the cellular damage associated with smoking. OBJECTIVE: The aim of this study was to investigate whether atorvastatin protects against smoking-induced inflammation in alveolar epithelial type I (ATI) and type II (ATII) cells in the lungs of rats. METHODS: Adult male albino Wistar rats (200-250 g) were randomly divided into 3 groups and exposed to cigarette smoke 8 hours per day for 15 days. During that 15-day period, the 2 treatment groups received atorvastatin 0.5 or 1.0 mg/kg/d in 2 mL of methyl cellulose solution and the control group received 2 mL of methyl cellulose solution alone, all via nasogastric catheter. After the 15 days, the lungs were excised and the tissues were examined by transmission electron microscopy. RESULTS: Thirty rats were divided into 3 groups of 10 rats each. All rats survived the 15 days. In the atorvastatin 0.5-mg group, no changes were found in the ATI cells or in the blood-air barrier. In the atorvastatin 1.0-mg group, we observed hyperplasia in the common basal membranes. Hypertrophy, mitochondrial crystolysis (MC), and intracytoplasmic edema (ICE) were detected in the ATI cells in the 1.0-mg group, while chromatin condensation, atrophic appearance, cell shrinkage, and cytoplasmic vacuolization were observed in the ATII cells. The rough endoplasmic reticulum (rER) tubules of the ATII cells appeared spiral-shaped. In the control group, minimal ICE was detected in the ATI cells. However, microvillus deformation, pseudopod formation, edema, mitochondrial swelling, and MC were observed in the ATII cells. We also observed MC, several pinocytic vesicles, and normal rER tubules in the endothelial cells of the control group. CONCLUSIONS: The administration of atorvastatin 0.5 mg/kg/d was associated with some attenuation of lung injury caused by smoke inhalation in these rat lungs. However, atorvastatin 1.0 mg/kg/d was associated with lung damage. Future studies are needed to evaluate the dose-response relationship of atorvastatin to smoking-induced alveolar damage. (Curr Ther Res Clin Exp. 2009;70:366-376) (C) 2009 Excerpta Medica Inc.Öğe Electronic Smoking In Parents In Pregnancy; A Multicenter Cross-Sectional Study(European Respiratory Soc Journals Ltd, 2018) Yildirim, Elif Ozari; Duru, Serap; Sevim, Tulin; Topcu, Fusun; Gemicioglu, Bilun; Ozmen, Ipek; Ocakli, Birsen[Abstract Not Available]Öğe Environmental Asbestos-Related Pleural Plaque in Southeast of Turkey(Heldref Publications, 2010) Ates, Gungor; Yildiz, Tekin; Akyildiz, Levent; Topcu, Fusun; Erturk, BaykalIt is known that many malignant and benign pleural diseases occur due to environmental exposure to mineral fibers. Calcified pleural plaque (CPP) is an important sign of asbestos exposure on chest radiographic examination. To study the possible change in the prevalence of CPP and diffuse pleural thickening 3 decades after cessation of asbestos exposure. CPP were detected in 29.9% of the villagers; 4.7% had diffuse pleural thickening and 0.7% had asbestosis. The significant variable for CPP and diffuse pleural thickening was age. The youngest villager with CPP was 33 years of age and the prevalence of CPP increased with an increase in age. The reason for our cases with CPP being of advanced age is the discontinuation of asbestos exposure. This finding enables us to suggest that environmental asbestos-related disease will gradually decrease in future decades.Öğe Evaluation of COPD Patient's Relatives Assessment of Disease Awarness, Load of Care Giving and Loss of Workforce: Turkish Thoracic Society COPD Working Group.(European Respiratory Soc Journals Ltd, 2018) Baha, Ayse; Kokturk, Nurdan; Yildirim, Elif; Ozmen, Ipek; Gurgun, Alev; Topcu, Fusun; Akpinar, Eylem[Abstract Not Available]Öğe Incidence of Tuberculosis Disease and Latent Tuberculosis Infection in Patients with End Stage Renal Disease in an Endemic Region(Taylor & Francis Ltd, 2010) Ates, Gungor; Yildiz, Tekin; Danis, Ramazan; Akyildiz, Levent; Erturk, Baykal; Beyazit, Huseyin; Topcu, FusunAim. Patients in chronic renal failure suffer impaired cellular immunity and have an increased risk of tuberculosis (TB). Our aim in this multicenter study was to determine the incidence of TB and to evaluate latent tuberculosis infection (LTBI) in hemodialysis patients. Methods. We retrospectively evaluated the frequency of TB in 779 dialysis patients at 13 hemodialysis centers in five different cities in Southeast Turkey. The tuberculin skin test (TST) was conducted in 733 patients to detect LTBI. Results. The mean age of the patients was 51.2 +/- 15.9 years; 398 (51.1%) of the patients were female, and 53.9% of patients had a BCG scar. The mean dialysis duration time was 35.1 +/- 33.4 months. TB was diagnosed in 34 cases. The incidence rate of TB in patients undergoing hemodialysis was 3.1%. Ten patients had a history of TB before beginning hemodialysis, and 24 patients had a history of TB after beginning hemodialysis. A diagnosis of TB was made based on clinical data in eight patients and microbiologically or pathologically in 26 patients. The median time between the initiation of dialysis to the diagnosis of TB was 11 months. Extrapulmonary TB occurred in 45.8% of cases, and the most common site of involvement was the lymph nodes. The TST was positive in 61.8% of TB patients and in 37.5% of those with no history of TB. Conclusions. The incidence of TB is high in hemodialysis patients, and they should be evaluated periodically to exclude insidious infection and reduce morbidity and mortality.Öğe Nutritional risk factors for the development of chronic obstructive pulmonary disease (COPD) in male smokers(Churchill Livingstone, 2006) Celik, Fatma; Topcu, FusunBackground & Aims: The aim of this study was to investigate whether nutritional risk factors, especially black tea consumptions, are inversely associated with the development of chronic obstructive pulmonary disease (COPD) in male smokers. Methods: Forty male smokers with clinical diagnosis of COPD (Group-I (GI)) and 36 healthy smokers without COPD (Group-II (GII)) were included in this study. We compared the dietary habits and food intakes of the two groups using an adaptation of the Arizona Food Frequency Questionnaire (AFFQ). Question form included a list of 65 food items formed from five main food groups (grain, meat and alternatives, dairy products, vegetables-fruits and fat) and 25 dietary habits. The data were evaluated by binary logistic regression analysis, receiver operating characteristic (ROC) curve, Kolmogorov-Smirnov, Student's t, Mann-Whitney, and Chi-square tests. Results: When both groups compared, black tea consumptions (GI-700 ml; GII-1600ml (OR: 0.635, P < 0.001)), vegetable fruits scores (GI-54.30; GII-63.81 (OR: 0.863, P < 0.001)), regularly breakfast habit (GI-24 patients; GII-36 cases (OR: 0.549, P < 0.001)) and eating salty (GI-22 patients; GII-5 cases (P < 0.001)) made significant differences. In ROC curves, the area under the curve of black tea (0.898 (95% CI: 0.819-0.977) and vegetables-fruits (0.833 (95% CI: 0.727-0.938) provided high accuracy to distinguish between COPD group and controls (P < 0.001). Conclusions: High intakes of black tea and vegetables-fruits consumptions may be protecting male smokers from developing COPD. (c) 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.Öğe Role of D-Dimer, Fibrinogen and D-Dimer/Fibrinogen Rate in the Diagnosis of Pulmonary Embolism(Duzce Univ, 2016) Yilmaz, Sureyya; Topcu, Fusun; Ates, Gungor; Yildiz, Tekin; Bogatekin, GulhanObjective: The migration of a blood clot from the systemic circulation to pulmonary veins is called pulmonary embolism (PE). Pulmonary embolism is difficult to diagnose. The aim of the present study is to investigate the utility and diagnostic contribution of d-dimer, fibrinogen level, and Ddimer/ Fibrinogen (D/F) rate which are quick, non-invasive, affordable and easily obtainable laboratory tests in PE. Methods: We have evaluated the diagnostic value of D/F rate in 118 patients who were suspected to have PE. Diagnosis of PE was made by computerized tomographic pulmonary angiography. D-dimer level was above normal in all patients. Initially, Wells clinical scoring was applied on the patients and their d-dimer and fibrinogen levels were measured. Results: Seventy seven patients were detected as PE positive (+) and 41 were detected as PE negative (-). Forty-eight of the cases (40.7%) were male; the average age was 49.77 +/- 19.46 (15-86) years. Between PE (+) and PE (-) patients, d-dimer, fibrinogen, and D/F rate median values and standard derivations were detected to be different and statistically significant. Conclusion: According to this study approach to the patients with suspected from PE, D/F ratio is valuable than d-dimer, and fibrinogen level is significantly lower in patients with PE (+) than patients with PE (-).Öğe The role of inflammatory biomarkers in obstructive sleep apnea syndrome(European Respiratory Soc Journals Ltd, 2018) Yilmaz, Sureyya; Sen, Hadice Selimoglu; Taylan, Mahsuk; Demir, Melike; Topcu, Fusun; Senyigit, Abdurrahman; Kirbas, Gokhan[Abstract Not Available]Öğe Work related symptoms of adult patients with asthma: A multicenter, national, questionnaire based study(European Respiratory Soc Journals Ltd, 2015) Mungan, Dilsad; Ozmen, Ipek; Evyapan, Fatma; Topcu, Fusun; Akgun, Metin; Arbak, Peri; Bulbul, Yilmaz[Abstract Not Available]
