Yazar "Tekin, Recep" seçeneğine göre listele
Listeleniyor 1 - 20 / 110
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A 32-year-old male with an ulcer with necrotic crusts on the right arm(2011) Çelen, Mustafa Kemal; Boşnak, Vuslat; Yeşilova, Yavuz; Ayaz, Celal; Tekin, Recep[Abstract Not Available]Öğe A 32-year-old male with an ulser with necrotic crusts on the right arm(Marmara Univ, Fac Medicine, 2011) Tekin, Recep; Yesilova, Yavuz; Boşnak, Vuslat; Celen, Mustafa Kemal; Ayaz, Celal[Abstract Not Available]Öğe A 4-Year Surveillance of Device-associated Nosocomial Infections in a Neonatal Intensive Care Unit(Elsevier Taiwan, 2013) Tekin, Recep; Dal, Tuba; Pirinccioglu, Habibe; Oygucu, Seyhan ErisirBackground: The aim of this study was to determine the rate of health care-associated infection (HC-AI) and device-associated health care-associated infections (DA-HAIs), and distribution of causative microorganisms and etiologic factors responsible for these infections in a neonatal intensive care unit (NICU) of a state hospital in southeastern Turkey. Methods: A laboratory-based, active, prospective nosocomial infection surveillance study was performed in NICUs from January 2008 to December 2011. The rates of HC-AIs were determined on a daily basis. The findings were evaluated by applying the definitions of the Centers for Disease Control and Prevention National Healthcare Safety Network. Results: In a 4-year period, 580 HC-AIs, 81 of which were DA-HAIs, were detected among 6932 patients. The rate of hospital acquired infection was 8.3% and 7.69/1000 patient days. Ventilator-associated pneumonia (YAP) was the second most frequent (13.1%) HC-AI and the most frequent was DA-HAI. The VAP rate was 6A per 1000 ventilator days. Mechanical ventilation was the most frequently used invasive device. Median time to diagnosis of VAP was 32.11 +/- 29.3 days from the time of admission. Acinetobacter baumannii (48%) and Pseudomonas aeruginosa (32%) were the most frequent microorganisms. Colistin was the most effective antibiotic by in vitro test. The antibiotic resistance ratios of A. baumannii were >= 54% for carbapenems, aminoglycosides, and cefoperazone-sulbactam; >= 88% for quinolones; and >= 92% for ceftazidime, ceftriaxone, and piperacillin-tazobactam. Conclusions: Device-associated nosocomial infections was a particularly important problem in NICU. Close monitoring will decrease the rates of device-related nosocomial infections. Copyright (C) 2013, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. All rights reserved.Öğe Acute hemorrhagic encephalitis in a pregnant woman with coronavirus disease-2019(Sociedade Brasileira de Medicina Tropical, 2022) Tekin, Rojbin Ceylan; Gökhaner, Yurdagül Tolu; Tekin, RecepA 32-year-old pregnant woman with a 12-day history of fever and cough was admitted to the emergency department for confusion and severe headache at 24 weeks of gestation. She reported a worsening condition for 5 days with headache, confusion, and dyspnea. Neurological examination showed dysarthria and mild hemihypoesthesia. A polymerase chain reaction test from the nasopharyngeal swab confirmed the diagnosis of coronavirus disease (COVID-19).Öğe Alt göz kapağında şarbon(2011) Çaça, İhsan; Boşnak, Vuslat; Ayaz, Celal; Çelen, Mustafa Kemal; Tekin, RecepEsas olarak ot yiyen hayvanların hastalığı olan şarbon, insanlara enfekte hayvanlardan bulaşan bir zoonozdur. Bu hastalığın en sık görülen formu, olguların yaklaşık % 95’inde saptanan deri şarbonudur; alt göz kapağı tutulumu ise nadirdir. 17 yaşındaki kadın hastanın sağ alt göz kapağında kaşıntılı ve eritemli papül şeklinde başlayan ve daha sonra kapağın tamamına yayılan, ödemin de eşlik ettiği lezyon mevcuttu. Alınan materyalde zincir şeklinde Gram pozitif basiller görüldü, ancak kültürde üreme olmadı. Orbital bilgisayarlı tomografide periorbital bölgede yumuşak doku şişliği saptandı. Lezyonun tipik olması ve Gram pozitif basiller görülmesi ile hastaya deri şarbonu tanısı kondu. Hastanın başlangıç ve idame tedavisi için ampisilin/sulbaktam verildi. Hastanın iki hafta sonraki kontrolünde her hangi bir komplikasyon gelişmeden tamamen iyileştiği gözlendi. Periorbital şarbon olgularında tedaviye rağmen skatrisyel ektropion ve lagoftalmus benzeri komplikasyonlar gelişebilir. Erken tanı konulup antibiyotik tedavisine başlanması komplikasyon oluşumunu anlamlı derecede azaltabilir. Bu olgu sunumunda şarbon hastalığında nadir olarak görülen, alt göz kapağı şarbonlu bir olgu rapor edilmiş olup, tanı ve tedavi yaklaşımları değerlendirilmiştir.Öğe Analysis of antimicrobial consumption and cost in a teaching hospital(Elsevier Science London, 2014) Bozkurt, Fatma; Kaya, Safak; Tekin, Recep; Gulsun, Serda; Deveci, Ozcan; Dayan, Saim; Hosoglu, SalihBackground: The aim of this study is to compare the periods before and after the intervention applied using the ATC/DDD method in order to ascertain the rational use of antibiotics in a newly established hospital. Method: The appropriateness of the hospital's antibiotic use, consumption rates and the costs were calculated and compared with other hospitals. Based on these data, an intervention has been planned in order to raise the quality of antibiotic use. The periods before and after the intervention were compared. Between 16 May 2011 and 23 May 2012, data were collected from all hospital units by the infectious diseases specialists and a point prevalence survey was conducted. Anatomical therapeutic chemical classification and the defined daily dose (DDD) methodology were used to calculate the antibiotic consumption. Results: On two specific days in 2011 and 2012, 194 out of 307 patients (63.2%) and 224 out of 412 patients (54.4%) received antibiotic treatment, respectively. In 2011 and 2012, the percentage of appropriate antibiotic use was 51% and 64.3%, respectively. Both in 2011 and 2012, inappropriate antibiotic use was found to be significantly higher in surgical clinics in comparison to the internal diseases clinics and the ICU. This was caused by the high rates of inappropriate perioperative antimicrobial prophylaxis observed in surgical clinics. During both years, approximately one-third of the antibiotics were prescribed for the purposes of perioperative prophylaxis, while 88.5% and 43.7% of these, respectively, were inappropriate and unnecessary. Cephalosporins, fluoroquinolones, combinations of penicillins (including ii-lactamase inhibitors) and carbapenems were the most frequently prescribed antibiotics during the study periods. The mean total antibiotic consumption was 93.6 DDD/100 bed-days and 63.1 DDD/100 bed-days, respectively. The cost of total antibacterial consumption was (sic) 7901.33 for all the patients ((sic) 40.72 per infected patient) and sic 6500.26 ((sic) 29.01 per infected patient), respectively. Conclusion: Each hospital should follow and assess their antibiotic use expressed in DDD in order to compare their antibiotic use with national and international hospitals (WHO, 2009 [14]). (C) 2013 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.Öğe ANTI-TUBERCULOSIS DRUG RESISTANCE IN SOUTHEAST OF TURKEY(Carbone Editore, 2013) Dal, Tuba; Ozcan, Nida; Tekin, Recep; Tekin, Alicem; Celen, Mustafa Kemal; Ozekinci, Tuncer; Dal, T.Objective: Tuberculosis is a globally prevalent life-threatening infectious disease. In this study we aimed to evaluate antibiotic suscebtibility rates of Mycobacterium tuberculosis complex strains. Materials and methods: A total of 150 culture-positive samples were included in. Among culture positive samples 86 were Mycobacterium tuberculosis complex and 64 were non-tuberculous mycobacterium. Of Mycobacterium tuberculosis complex isolated samples 45 were Ziehl-Neelsen positive. Of 64 non-tuberculous mycobacterium isolated samples 15 were Ziehl-Neelsen positive. Mean age of the patients with tuberculosis was 37.74 +/- 20.53 and non-tuberculous mycobacterium isolated patients was 46.80 +/- 23.32. Antibiotic susceptibility testing was performed for the four first-line anti-tuberculosis drugs by BACTEC MGIT-960 instrument (Becton Dickinson). Of M. tuberculosis strains 41 % was resistant to at least one or more of the drugs (isoniasid 27.9%, ethambutol 8.13%, streptomycin 12.79 %, rifampicine 9.3 %). Of the strains 5.8 % was resistant to two, 3.4 % to three and 3.4 % to four drugs. Conclusion: Mycobacterium tuberculosis complex and drug resistance of this microorganism continued to be a problem for our country and non-tuberculous mycobacterium species may become a problem in the future. We thought that a strong and cost-effective tuberculosis control programme contributes to reduce the incidence of drug resistance in the community.Öğe Antifungal susceptibility and risk factors in patients with candidemia(Atatürk Üniversitesi Tıp Fakültesi, 2016) Mermutluoğlu, Çiğdem; Deveci, Özcan; Dayan, Saim; Aslan, Emel; Bozkurt, Fatma; Tekin, RecepAmaç: Bu çalışmanın amacı bir üniversite hastanesinde yatan pediatrik ve erişkin hastalarda gelişen kandideminin risk faktörlerini, suşların tiplerini ve antifungal duyarlılıklarını araştırmaktır.Gereç ve Yöntem: Çalışma bir olgu - kontrol çalışması olarak planlandı. Aralık 2013- Aralık 2014 tarihleri arasında bir yıl boyunca hasta verileri retrospektif olarak kaydedildi. Vaka grubuna kandidemi gelişen hastalar alındı. Kontol grubuna, her vakaya karşılık bir kontrol hastası olmak üzere, kandidemi gelişmeyen hastalar seçildi. Kandidemi tanısı kan kültüründe Candida spp pozitifliği ve klinik tabloya uyumlu olarak konuldu. Her iki grup için demografik özellikler, SOFA (Sequental Organ Failure Assessment) skoru, eşlik eden hastalıklar, invaziv alet kullanımı, kullanılan antibiyotikler ve süreleri kaydedildi.Bulgular: 84 hastanın 42'sinde (%50) olgu grubuna, kalan 42'sinde (%50) kontrol grubuna dahil edildi. Tüm hastalardan 31 (%36.9) kadın, 53 (%63.1) erkekti. Olgu ve kontrol gruplarının klinik bulguları karşılaştırıldığında, olgu grubunda nozokomiyal enfeksiyonlar, sepsis, candidüri ve ateş prevalansı istatistiksel olarak anlamlı derecede yüksekti. Çalışmada izole edilen 42 suşun 22'si (%52,4) candia albicans, diğerleri non candida albicans olarak belirlendi. Candida albicans suşunun sadece birinde (%4,5) flukonazola direnç saptanırken, noncandida albicans suşlarının 7'sinde (%35) flukonazole direnç saptandı. Olgu grubunda batın cerrahi uygulaması, CVP (Santral Venöz Basınç) kateteri varlığı, Total parenteral nutrisyon(TPN), endotrakeal entübasyon, kan transfüzyonu sıklığı ve SOFA skoru kontrol grubuna göre anlamlı şekilde yüksek tespit edildi. Lojistik regresyon testi, TPN ve kan transfüzyonunun, kandidemi için en önemli risk faktörü olduğunu göstermiştir. Sonuç: Kandida enfeksiyonları ülkemizde ve hastanemizde önemli bir sağlık sorunu olmaya devam etmektedir. Sonuç olarak antibiotik tedavisine yanıt alınamayan, TPN alan, CVP kateteri takılan, kan transfüzyonu ve batın cerrahisi uygulanan hastalarda kandidemi riski göz ardı edilmemelidir.Öğe Approach to Treatment of Diabetic Foot Infection(Duzce Univ, 2012) Bozkurt, Fatma; Tekin, Recep; Celen, Mustafa Kemal; Ayaz, CelalBackground: Foot infections in diabetic patients and frequently require a multidisciplinary approach to solving a problem. Taking the form of cellulite, soft tissue necrosis and osteomyelitis may present risks for limb amputation. Bakterolojik analysis for this reason, treatment is very important. Aim: This study aimed to determine the active micro-organisms and their antibiotic susceptibilities. Methods: A total of 63 patients with Diabetic foot infection, who were admitted to the clinics of Dicle University Hospital between October 2006 and November 2007, were included into the study. Wagner classification metod used for wound classification. Deep tissue culture was maked for bacteriological analysis. For aerobic and anaerobic culture were rapidly sent to laboratory. Results: While 38 (60%) of patients, Wagner classification <= 2, Wagner classification >= 3 was 25 (40%) The most common isolated microorganisms are S. aureus (20 patients, 31.7%) and it was followed by Klebsiella spp. and Enterobacter cloaca. All Gr (-) isolates the most effective antibiotics against amikacin, meropenem, piperacillin-tazobactam and cefepime, respectively. They are the most resistant to the antibiotics ciprofloxacin and cefuroxime-axetil, respectively. Conclusion: An effective treatment for diabetic foot infections, determination of causative organisms and their antibiotic susceptibility is crucial to know the sensitivity shown in most of the time.Öğe Aspergillus encephalitis with microabscesses in an immunocompetent patient(Sociedade Brasileira de Medicina Tropical, 2023) Tekin, Recep; Hattapoğlu, Salih; Tekin, Rojbin CeylanA 28-year-old man presented to the emergency department with a 5-week history of severe headache, dizziness, and weakness in the right arm. Neurological examination revealed 3/5 strength in the right arm. Brain magnetic resonance imaging (MRI) of the brain showed a large hypointense lesion with thick peripheral contrast enhancement in the left periventricular area. The solid components appeared hyperintense after contrast enhancement, and microabscesses were observed in the basal ganglia, subcortical white matter, and left anterior thalamic areaÖğe Assessment of cases with intracranial hydatid cyst: A 23-year experience(Ege Nöroloji Derneği, 2014) Turan, Yahya; Yılmaz, Tevfik; Göçmez, Cüneyt; Kamaşak, Kağan; Kemaloğlu, Serdar; Tekin, Recep; Hattapoğlu, Salih; Bozkaya, Halil; Çalışkan, Alper; Ceviz, AdnanObjective: Brain is involved in 1-2% of hydatid cyst infections. A cranial location is rare. In this study, we aimed to assess clinical findings, radiological investigations, and treatment modalities of cases with intracranial hydatid cyst. Materials and Method: The present study included 26 patients operated for cerebral hydatid cyst disease between January 1990 and October 2012. Results: Seventeen patients were male and 9 were female. The mean age of the study population was 20.3 years (range 7-50 years). Headache and nausea were the most common clinical symptoms. The lesions were demonstrated by computed tomography (CT) and magnetic resonance imaging (MRI) as large, smooth, thin walled, spherical-shaped, cystic homogenous lesions with the same density as cerebro spinal fluid, which showed no edema or contrast uptake. Two patients were complicated or infected cysts with perifocal edema and contrast uptake. In 20 patients, the cysts were removed completely with Dowlings technique, by rectifying cysts without rupturing. Eleven patients with ruptured cysts during operation, recurrent or systemic hydatid cyst were treated medically. Conclusion: Medical therapy appears effective in hydatid cyst disease. Cerebral hydatid cysts should be excised totally without rupturing them. Preoperative imaging techniques are central to surgical planning. Intracranial hydatid cyst should be remembered when CT or MRI shows a cystic lesion, especially in countries where hydatid cyst is endemic.Öğe Assessment of Cases With Intracranial Hydatid Cyst: A 23-Year Experience(2014) Ceviz, Adnan; Kemaloğlu, Serdar; Hattapoğlu, Salih; Çalışkan, Alper; Tekin, Recep; Bozkaya, Halil; Gocmez, CüneytAmaç: Kist hidatik enfestasyonlarının %1-2'sinde beyin tutulumu olur. Kranial yerleşimyetişkinlerde nadirdir. Bu çalışmada intrakraniyal kist hidatik olguların; klinik bulguları,radyolojik görüntülemeleri ve tedavilerin irdelemeyi amaçladık.Materyal ve metod: Bu çalışma Ocak 1990- Ekim 2012 yılları arasında serebral kist hidatiknedeniyle opere edilmiş olan 26 hastayı içermektedir.Bulgular: Hastaların 17'si erkek ve 9'u kadın olup, yaş ortalaması 20,3 (yaş aralığı 7-50) idi.Baş ağrısı ve kusma en sık görülen klinik semptomlardı. BT ve MRG'de büyük düz, inceduvarlı, sferikal şekilli, BOS ile aynı dansiteye sahip olan ve perifokal ödem içermeyen,kontrast tutmayan kistik homojen lezyonlar şeklinde gösterildi. Hastaların 2 tanesi komplikeveya enfekte kist olup bunlarda perifokal ödem ve kontrast tutulumu vardı. 20 hastada kistlerrüptüre olmaksızın Dowling teknigi ile doğurtularak total olarak çıkarıldı. Cerrahi sırasındakist hidatiği rupture olan, rekürrensi olan ya da sistemik hidatik kisti olan 11 hasta medikaltedavi aldı.Sonuç: Medikal tedavinin kisthidatikte etkili olduğu görünüyor. Serebral kisthidatiklerrüptüre olmadan total çıkarılmalıdır. Preoperatif görüntüleme yöntemleri cerrahi planlamadaçok önemlidir. Özellikle Kisthidatik hastalığının endemik olduğu ülkelerde, BT veya MRG'dakistik bir lezyon görüldüğü zaman, İntrakranial Kist hidatik akılda tutulması gereken birhastalıktır.Öğe Assessment of Cases With Intracranial Hydatid Cyst: A 23-Year Experience(Journal Neurological Sciences, 2014) Turan, Yahya; Yilmaz, Tevfik; Gocmez, Cuneyt; Kamasak, Kagan; Kemaloglu, Serdar; Tekin, Recep; Hattapoglu, SalihObjective: Brain is involved in 1-2% of hydatid cyst infections. A cranial location is rare. In this study, we aimed to assess clinical findings, radiological investigations, and treatment modalities of cases with intracranial hydatid cyst. Materials and Method: The present study included 26 patients operated for cerebral hydatid cyst disease between January 1990 and October 2012. Results: Seventeen patients were male and 9 were female. The mean age of the study population was 20.3 years (range 7-50 years). Headache and nausea were the most common clinical symptoms. The lesions were demonstrated by computed tomography (CT) and magnetic resonance imaging (MRI) as large, smooth, thin walled, spherical-shaped, cystic homogenous lesions with the same density as cerebro spinal fluid, which showed no edema or contrast uptake. Two patients were complicated or infected cysts with perifocal edema and contrast uptake. In 20 patients, the cysts were removed completely with Dowlings technique, by rectifying cysts without rupturing. Eleven patients with ruptured cysts during operation, recurrent or systemic hydatid cyst were treated medically. Conclusion: Medical therapy appears effective in hydatid cyst disease. Cerebral hydatid cysts should be excised totally without rupturing them. Preoperative imaging techniques are central to surgical planning. Intracranial hydatid cyst should be remembered when CT or MRI shows a cystic lesion, especially in countries where hydatid cyst is endemic.Öğe Assessment of Hand Functions in Patients with Chronic Hepatitis B(Aves, 2014) Oktayoglu, Pelin; Tekin, Recep; Caglayan, Mehmet; Bozkurt, Mehtap; Em, Serda; Yildiz, Mehmet; Ucmak, FeyzullahObjective: Motor dysfunction is an important clinical finding in patients with liver cirrhosis (LC), but there is no study assessing fine motor coordination in patients with chronic hepatitis B (CHB). We aimed to investigate hand functions and fingertip dexterity in patients with CHB. Materials and Methods: A total of 17 female and 15 male patients diagnosed with CHB without histopathological findings of cirrhosis were enrolled to the study; 21 female and 9 male healthy volunteers were included as a control group. Hand grip strength was assessed by Jamar hand dynamometer. Three kinds of pinch strength of fingers were assessed by Jamar pinchmeter. Functional status was evaluated by using the Stanford Health Assessment Questionnaire (HAQ). Duruoz Hand Index (DHI) was used to assess the hand functions. Fingertip dexterity was evaluated by Purdue pegboard test. Results: Bilateral hand grip strength and pinch strength were not statistically different from controls (p>0.05). There was also no significant difference between the categories of the Purdue pegboard test between the groups. HAQ scores of patients were higher than controls (p< 0.05). Conclusion: Hand functions are not influenced in patients with CHB. Disruptions in the functional status of patients with CHB may be due to fatigue and depression, which are usually seen in chronic liver diseases.Öğe Assessment of perioperative antimicrobial prophylaxis using ATC/DDD methodology(Elsevier Ltd., 2013) Bozkurt, Fatma; Kaya, Şafak; Gülsün, Serda; Tekin, Recep; Deveci, Özcan; Dayan, Saim; Hoşo?lu, SalihObjectives: In the light of international experience and guidelines and in order to improve the quality of perioperative antimicrobial prophylaxis (PAP), various hospitals have set up their own multidisciplinary healthcare teams and have evaluated the density of PAP through close supervision and interventions. The aim of the present study was to compare the density, quality, and cost of PAP before and after an intervention implemented at our hospital in order to increase the quality of PAP. Methods: PAP was monitored using a form prepared in line with the international guidelines, which was completed by the infection control nurse under the supervision of the infectious diseases specialist. In order to reduce the frequent errors in our PAP procedures, an intervention was implemented, and the period before this intervention (January–April 2011) was compared with the post-intervention period 1 year later (January–April 2012). The density of PAP was calculated according to the Anatomical Therapeutic Chemical classification/defined daily dose (ATC/DDD) methodology. Results: A total of 2398 patients received PAP during this period. The most frequently used antibiotic before and after the intervention was cefazolin. Its use further increased after the intervention (p < 0.001). After the intervention, the ratio of the correct timing of the first antibiotic dose increased from 91.7% to 99.0% (p < 0.001), while the excessively long administration of PAP was reduced from 77.0% to 44.7% (p < 0.001). The ratio of full compliance with the guidelines increased from 15.5% to 40.2% (p < 0.001) and the rate of surgical site infections dropped from 18.5% to 12.0%. The density of antibiotic use dropped from 305.7 DDD/100 procedures = 3.1 DDD/procedure to 162.1 DDD/100 procedures = 1.6 DDD/procedure. Conclusion: The quality of PAP may be improved through better compliance with healthcare guidelines, close supervision, and training activities. Also, surgical site infections and the cost of PAP may be reduced through more appropriate antibiotic use, thus contributing to the national healthcare budget.Öğe ASSESSMENT OF THE LABORATORY TRANSMISSION OF BRUCELLOSIS IN AN ENDEMIC REGION(Carbone Editore, 2014) Deveci, Ozcan; Tekin, Recep; Aslan, Emel; Hosoglu, Salih; Bozkurt, Fatma; Dayan, Saim; Demirpence, OzlemObjectives: Laboratory-acquired brucellosis (LB) has been one of the most commonly reported laboratory-associated bacterial infections in both endemic and non-endemic countries. Brucellosis is endemic in Turkey. The aim of this study is to describe the risk factors of LB among laboratory healthcare workers. Material and method: A regional survey study was conducted by face-to-face interview in 7 hospitals from Diyarbakir, Mardin and Batman province, in southeaster Anatolia in Turkey. A structured survey questionnaire was administered to the Laboratory healthcare workers, employed in infectious diseases clinics and microbiology departments, who were at risk of Brucella infection. Result: Of the 136 laboratory workers, 13 (9.5%) had a history of laboratory-acquired brucellosis. Logistic regression analysis identified factors independently associated with an increased risk of LB including lack of biosafety cabinet (P<0.005) and a lack of compliance in the use of the same (P<0.005). Using a biosafety cabinet (P<0.005), existence of biosafety cabinet (P<0.005), full adherence to glove use (P<0.005) and male gender(P<0.005) were found to be protective factors. Conclusion: Increased adherence to personal protective equipment and use of biosafety cabinets should be priority targets to prevent LB.Öğe Aynı Hastada Fascioliazis ve Bruselloz(2014) Deveci, Özcan; Tekin, Recep; Çetinçakmak, Mehmet Güli; Aslan, Emel; Tekin, Alicem; Bozkurt, Fatma; Toka-Özer, TürkanBruselloz birçok organı ve sistemi etkileyebilen çok farklı klinik tablolara yol açan zoonotik bir enfeksiyon hastalığıdır. Brusellozun farklı enfeksiyon etkenleri ile birlikteliği nadirdir. Fascioliazis; halk arasında büyük karaciğer kelebeği olarak adlandırılan yaprak şeklindeki Fasciola hepatica'nın neden olduğu zoonotik bir hastalıktır. Olgumuz 39 yaşında erkek hasta bir hafta önce başlayan üşüme, titreme, ateş, karın ağrısı, bulantı, kusma, halsizlik, terleme ve yaygın vücut ağrısı şikâyetleri olmuştu. Hastanın ön tanısında bruselloz düşünüldü. Buna yönelik olarak istenen tetkiklerde rose bengal testi pozitif, Wright testi (1/640) pozitif saptandı. Karaciğer enzim yüksekliği olması üzerine batın ultrasonografisi (USG) yapılan hastada karaciğerde lezyon görülmesi nedeniyle batın bilgisayarlı tomografi (BT) çekildi. BT sonucu karaciğer sol lob segment 2'de büyük oranda nekrotik görünümde yaklaşık olarak 61x63 mm boyutlarında kontrast tutulum göstermeyen (fascioliazis ile uyumlu) alan izlendi şeklinde sonuç geldi. Fascioliazise yönelik olarak IHA testi istenen hastanın sonucu 1/320 pozitif saptandı. Zoonotik hastalıklar için yüksek endemisiteye sahip olan bölgelerde, risk grubunda olan hastalarda birden fazla enfeksiyon etkeninin bir arada olabileceği göz önünde bulundurulmalıdır.Öğe Bacterial profile and drug susceptibility pattern of urinary tract infection in pregnant women with ureteral stones and hydronephrosis(Academic Journals, 2012) Atar, Murat; Bozkurt, Yasar; Sancaktutar, Ahmet Ali; Soylemez, Haluk; Penbegül, Necmettin; Sak, Muhammet Erdal; Tekin, RecepThe aim of this study is to identify bacterial agents and their antibiotic susceptibility patterns isolated from pregnant women with symptomatic ureterolithiasis. Seventeen patients who had proven ureteral stones, positive urine cultures and underwent intervention for ureterolithiasis treatment between January, 2008 to December, 2011 were included in this study. Bacteriuria was defined as accounts of 10(5) cfu/ml in urine culture. The mean age and gestational period was 24.5 years and 25.5 weeks. The major symptoms were renal colic, hematuria and fever-chills. The overall prevalence of urinary tract infection (UTI) in pregnancy with ureteral stones was 17/65 (26.2%). Escherichia coli are the most common etiological agent (64.7%), followed by Klebsiella and Staphylococcus. The rate of resistance of E. coli to amoxicillin-clavulanate, ampicilin, cefotaxime, ciprofloxacin, trimethoprim/sulfamethoxazol, ceftriaxone, piperacillin/ tazobactam and imipenem were 50, 45.5, 100, 18, 36.4, 28.6, 36.4, 0%, respectively. The rate of resistance of Klebsiella to Ampicilin were 80% and Amoxicillin-Clavulanate, Cefazolin, Cefepime, Ceftazidim were 60%. There were no resistance of Klebsiella to ciprofloxacin, gentamicin, meropenem and amikacin. Significant bacteriuria was observed in these patients and we recommend urine cultures in all pregnant women with ureteral stones during pregnancy. Ceftriaxone is recommended for the patients who have UTI with ureteral stones during pregnancy because of its high specificity and sensitivity.Öğe Bacterial translocation and inflammatory alterations in an experimental intestinal obstruction model in splenectomized rats(Aves, 2012) Sirca, Tarik; Onder, Akin; Kapan, Murat; Tekin, Recep; Firat, Ugur; Evliyaoglu, Osman; Taskesen, FatihPurpose: Intestinal obstruction leads to an increase in the secretion of pro-inflammatory and inflammatory cytokines, oxidative injury, mucosal barrier dysfunction and bacterial translocation with the deterioration of normal ecological balance. Mitogenic activity resulting from splenectomy is reported to influence the development of bacterial translocation as a result of an increase in the proliferation of T cells and a decrease in the levels of serum tufsin. In this study, we aimed to investigate the effect of splenectomy on bacterial translocation and inflammatory response alterations resulting from the intestinal obstruction in rats. Materials and Methods: Twenty-four rats were divided into 3 groups as follows: Group 1 (Sham), only the ileocecal junction dissection; Group 2 (intestinal obstruction), complete ileal ligation; Group 3 (Splenectomy + intestinal obstruction), splenectomy following complete ileal ligation. 24 hours after the initial laparotomy, rats were sacrificed with the reception of intra-cardiac blood. Peritoneal swap, mesenteric lymph node, liver and ileal specimens, taken in sterile conditions, were examined microbiologically, biochemically and histopathologically. Results: Intestinal obstruction resulted in a significant increase in bacterial translocation, oxidative stress, inflammation, and ileal mucosal injury (p<0.05). No significant difference occurred between the splenectomized and non-splenectomized rats. Similar asimetric dimethylarginine levels were observed in all groups (p>0.05). Conclusions: It was proven that splenectomy has no significant effect on the bacterial translocation and inflammation in experimental intestinal obstruction models in rats.Öğe Biomarker insights: Evaluation of presepsin, apelin, and irisin levels in cutaneous leishmaniasis(Mdpi, 2024) Erkan, Revşa Evin Canpolat; Tekin, Recep; Sula, BilalBackground/Objectives: Cutaneous leishmaniasis (CL) is a skin disease caused by Leishmania parasites. Presepsin, irisin, and apelin are biomarkers that are involved in the inflammatory response. The aim of this study was to investigate the association between serum levels of specific biomarkers, such as presepsin, apelin, and irisin, and the clinical features, location, number, and size of lesions in patients with CL. Methods: This study is a single-centre, prospective cohort study involving a total of 30 patients with skin lesions compatible with CL and 30 healthy matched controls. Age, sex, type of skin lesion, location of skin lesion, number of skin lesions, and diameter of skin lesions were recorded. The levels of presepsin, irisin, and apelin measured in the blood samples of the patient group were analysed in comparison to those in the healthy control group. Results: The findings revealed that presepsin levels were significantly elevated in the patient group compared to the controls (p = 0.000). However, no statistically significant differences were observed between the groups for irisin and apelin levels (p-values 0.096 and 0.836, respectively). A negative correlation was identified between presepsin levels and the number of skin lesions, the diameter of the largest lesion, and the total diameter of the lesions (p = 0.000). Conclusions: It appears that measuring presepsin levels in patients with CL may be beneficial. Presepsin has the potential to serve as a prognostic marker in CL, offering significant benefits in guiding clinicians in assessing disease progression and response to treatment.
