Yazar "Syed, Zeba A." seçeneğine göre listele

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    Descemet stripping endothelial keratoplasty outcomes in patients with rheumatoid arthritis
    (Lippincott William & Wilkins, 2021) Çınar, Yasin; Delvadia, Bela; Şahin, Alparslan; Hammersmith, Kristin M.; Nagra, Parveen K.; Rapuano, Christopher J.; Syed, Zeba A.
    Purpose: To review the graft and visual outcomes in a series of patients with rheumatoid arthritis (RA) who underwent Descemet stripping endothelial keratoplasty (DSEK). Methods: In this case series, the electronic medical records at Wills Eye Hospital were queried for cases of patients with RA who underwent DSEK between January 1, 2009 and September 1, 2018. Charts were reviewed to obtain demographic data, medical history, ocular history, surgical variables, graft survival, and visual acuity outcomes. Results: During the study period, 22 transplants performed in 18 eyes of 15 patients with RA were eligible for inclusion. The mean age at the time of initial DSEK was 70.5 +/- 11.1 years (range 46-87). The mean follow-up time for the included eyes was 4.89 +/- 2.71 years (range 1.95-10.39). The overall estimated graft survival was 8.26 +/- 0.81 years with a 5-year survival rate of 88.9%. A significant improvement from preoperative best corrected visual acuity (logarithm of the minimum angle of resolution 0.84, approximately 20/140) to the most recent follow-up (logarithm of the minimum angle of resolution 0.29, approximately 20/40) was noted (P < 0.001). Conclusions: In our case series, patients with a history of RA underwent successful DSEK with excellent graft survival rates and visual acuity outcomes. Well-controlled RA should therefore not be considered a deterrent to performing DSEK.
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    Long term results of accelerated corneal collagen cross-linking in pediatric keratoconus
    (Sage Publications Ltd, 2021) Cinar, Yasin; Han, Cagla Cilem; Sahin, Alparslan; Syed, Zeba A.
    Purpose: To evaluate the long term visual, refractive, and corneal tomographic outcomes of epithelium-off accelerated corneal collagen cross-linking (ACXL) in the management of pediatric keratoconus (KC). Methods: This retrospective study included patients under 18 years old with progressive KC who underwent ACXL between 2012 and 2019 at Dicle University Hospital. Complete ophthalmic examination was performed including uncorrected distance visual acuity (UDVA), best spectacle-corrected distance visual acuity (CDVA), manifest refraction, and corneal tomography. Evaluations were performed preoperatively and at 6 months intervals postoperatively. Results: Forty-nine eyes of 49 patients were included in the study. The mean age of patients at the time of ACXL was 14.2 +/- 1.8 (range: 9.5-17.3) years. Mean follow up was 4.61 +/- 1.90 (range: 2.0-8.1) years. The mean LogMAR UDVA improved from 0.94 +/- 0.41 to 0.81 +/- 0.43, 0.69 +/- 0.41, and 0.67 +/- 0.33 after 1, 3, and 5 years respectively (p = 0.001). The mean LogMAR CDVA improved from 0.58 +/- 0.36 to 0.46 +/- 0.31, 0.34 +/- 0.23, and 0.39 +/- 0.27 after 1, 3, and 5 years respectively (p = 0.015). The mean refractive cylinder improved significantly from 6.01 +/- 2.07 diopters (D) to 5.46 +/- 1.87, 5.38 +/- 2.18, and 5.02 +/- 2.31 D after 1, 3, and 5 years respectively (p = 0.005). As compared to preoperative values, steep keratometry and maximum keratometry were not significantly different (p = 0.805 and 0.448, respectively) following ACXL, while flat keratometry significantly improved after ACXL (p = 0.012). Although central corneal thicknesses decreased significantly (p = 0.029), the decrease in thinnest corneal thickness was not statistically significant (p = 0.205). Conclusion: Epithelium-off ACXL seems to be effective for halting KC progression with long term clinical benefits in pediatric patients.