Yazar "Sit, Dede" seçeneğine göre listele
Listeleniyor 1 - 20 / 30
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe The association of demographic, clinical, and thrombophilic factors with the failure of arteriovenous fistula among hemodialysis patients(Saudi Med J, 2008) Kadiroglu, Ali K.; Sit, Dede; Kayabasi, Hasan; Yilmaz, Zulfukar; Yilmaz, EminObjective: To evaluate the association of demographic, clinical, and thrombophilic factors with the failure of arteriovenous fistula (AVF) among patients undergoing chronic hemodialysis. Methods: Sixty-two (33 males, 29 females) patients undergoing chronic hemodialysis were included in the study in March 2005 at the Hemodialysis Center of the Medicine Faculty at Dicle University, Diyarbakir, Turkey. The patients were divided into 2 groups according to whether they needed (group II) or do not need (group 1) more than one fistula placed. Results: Female gender, longer vintage of hemodialysis, frequent intradialytic hypotensive episodes, elevated levels of phosporous, calcium-phosporous product (Cap), and intact parathormone (iPTH), and left ventricle hypertrophy were more likely in group 2. Conclusion: Arteriovenous fistula loss, and recurrent requirement of AVF constitution increase with hemodialysis vintage. We believe that female gender, frequent intradialytic hypotensive episodes, elevated serum levels of phosporous, iPTH, and high Cap products are risk factors related to the failure of AVF among hemodialysis patients.Öğe AN ATYPICAL LOCALISATION OF TUBERCULOSIS INFECTION IN PATIENTS UNDERGOING HAEMODIALYSIS: A CASE REPORT(Wiley, 2010) Kayabasi, Hasan; Sit, Dede; Kadiroglu, Ali Kemal; Yilmaz, Zulfukar; Bukte, YasarSpinal tuberculosis (TB) is a rare skeletal system localisation of TB in haemodialysis patients. In this paper, a case of Pott's disease with a psoas muscle abscess is reported. The patient had been on the dialysis programme for five years and was complaining of back pain, weight loss and weakness, which were investigated. A thoracolumbar magnetic resonance imaging showed multiple paravertebral abscesses invading the psoas muscle. TB diagnosis was made by microbiological analysis of specimen, which was obtained by fine needle aspiration under computerised tomography guidance.Öğe Bacteremia caused by Stenotrophomonas maltophilia in a dialysis patient with a long-term central venous catheter(Univ Chicago Press, 2006) Kara, Ismail Hamdi; Yilmaz, Mehmet Emin; Sit, Dede; Kadiroglu, Ali Kemal; Koekoglu, Oemer Faruk[Abstract Not Available]Öğe Carpal Tunnel Syndrome Based on Accumulation of ?2 Microglobulin With Vascular Steal Syndrome: A Case Report(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2006) Kadiroglu, Ali Kemal; Sit, Dede; Kayabasi, Hasan; Yilmaz, M. Emin; Isikoglu, BunyaminRheumatologic and osteoarticular syndromes occur frequently in chronic haemodialysis patients. The number and severity of these complications increase with the time on hemodialysis (HD). Beta-2 microglobulin accumulates in the soft tissue in HD patients due to its low level of clearance. Carpal tunnel syndrome (CTS) is one of the clinical expressions of this accumulation. Early diagnosis and treatment of CTS is important, since being late may lead to permanent defect and/or resistant symptoms.Öğe A Case With Pancytopenia Due to Hemodialysis Inadequacy (Case Report)(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2005) Sit, Dede; Kadiroglu, Ali Kemal; Yilmaz, M. Emin; Ayyildiz, M. Orhan; Isikoglu, BunyaminHemodialysis inadequacy affects not only morbidity and mortality of the dialysis patients, but it can also reduce the effectivity of therapies such as rHuEPO. Hemodialysis inadequacy and erythropoietin ineffectivity are the essential problems of the physicians who deal with patients who have end stage renal failure, and they reduce treatment success. We report a rarely seen case who has pancytopenia because of hemodialysis inadequacy and/or rHuEPO ineffectivity.Öğe Comparison of the effects of Losartan and Nebivolol on oxidative stress in patients with end stage renal disease(Oxford Univ Press, 2007) Kayabasi, Hasan; Kadiroglu, Ali Kemal; Sit, Dede; Selek, Sahabettin; Yilmaz, M. Emin[Abstract Not Available]Öğe Delirium With a Single Dosage of Acyclovir in a Continuous Ambulatory Peritoneal Dialysis Patient: Case Report(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2007) Kayabasi, Hasan; Kadiroglu, Ali Kemal; Kara, Ismail Hamdi; Sit, Dede; Yilmaz, M. EminValacyclovir is an effective oral agent for the treatment of herpes virus infection, however, the pharmacokinetics of the drug are altered in renal failure. It is increasingly recognized that dose adjustment of oral valacyclovir in renal failure is necessary to avoid neurotoxicity. We studied this drug in a continuous ambulatory peritoneal dialysis (CAPD) and immunocompromised patient. She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection. The elimination half-time (15 h) was similar to that reported for end-stage renal disease patients, while the steady-state volume of distribution (85 l) and the area under the curve concentration (127 mg/l.h) were greater. The mean CAPD dialysance was only 5.27 ml/min with less than 1% of an administered dose being recovered in the 24-hour dialysate. 48 h after interrupting treatment, she recovered normal neurological status and 500 mg of valacyclovir every 2 days was effective and well tolerated.Öğe Diagnosis and Treatment in Chronic Kidney Disease and Evalution of Cardiovascular Disease and Associated Risk Factors(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2008) Kadiroglu, Ali Kemal; Sit, Dede; Yilmaz, M. EminToday, chronic kidney disease (CKD) is a world-wide public health problem. Losing kidney function and occurance of cardiovascular disease (CVD) are inevitablely the main clinical outcomes. Increasing evidence suggested that the adverse outcomes of CKD can be prevented or delayed through early detection and treatment. CKD and hypertension are often present together and hypertension is both a cause and a complication of CKD and is a risk factor for progression of kidney disease and for CVD. The goals of antihypertensive therapy in CKD are to lower blood pressure, reduce the risk of CVD, slow progression of CKD and prevent the complications of decreased GFR. A clinical action plan should be developed for each patient, based on the stage of CKD and follow-up intervals for monitoring the patients should be determined by clinical condition.Öğe The effect of inflammatory reactions on antibody unresponsiveness to hepatitis B vaccine in hemodialysis patients(Briefland, 2007) Sit, Dede; Kadiroglu, Ali Kemal; Kayabasi, Hasan; Yilmaz, Zuelfuekar; Yilmaz, Mehmet EminBackground and Aims: In this study, the effect of infections and inflammation developed during hepatitis B vaccination program on antibody response in hemodialysis (HD) patients was evaluated. Methods: In total, 94 patients who had hepatitis B surface antigen (HBsAg) (-), antibody to hepatitis B surface (antiHBs) (-), antibody against hepatitis B core immunoglobulin G (antiHBclgG) (-) (Group A) and who were previously vaccinated but having antibody titer levels lower than 10 mIU/mL (Group B), on maintenance HD program were included in this study. In group A, 40 mu g intramuscular vaccine on 0, 1, 2 and 6 months and in group B, 40 mu g of intramuscular booster dose vaccine were administered. Antibody titer of 10 mIU/mL was considered as positive. Group A was then divided into two subgroups with respect to antibody response (Group A1 and Group A2). Results: Eighty-one patients completed the study (Group A; n=64, mean age=42.3 +/- 11.4 years; Group B: n=17, mean age=53.6 +/- 10.6 years). In Group A, antibody response was positive in 82.8% (Group A1), negative in 17.2% (Group A2) and it was positive in 100% of Group B. Inflammatory parameters, nutritional and demographic features were found similarly in all groups. Throughout the study, infections developed most frequently in Group A. Conclusions: We concluded that acute infections and inflammations developed in patients vaccinated according to vaccination schedule recommended for HBV prophylaxis during HD treatment does not affect antibody response and acute phase reactants are not indicators for negative antibody response.Öğe The effect of venlafaxine HCl on painful peripheral diabetic neuropathy in patients with type 2 diabetes mellitus(Elsevier Science Inc, 2008) Kadiroglu, Ali Kemal; Sit, Dede; Kayabasi, Hasan; Tuzcu, Alpaslan Kemal; Tasdemir, Nebahat; Yilmaz, M. EminObjective: The objective of this study was to evaluate the efficacy of venlafaxine HCl in the symptomatic treatment of painful peripheral diabetic neuropathy (PPDN) among patients with type 2 diabetes mellitus (DM). Design: This study was designed as a prospective, randomized, and controlled trial. Setting: This study was conducted at the Dicle University Medical Faculty (Diyarbakir, Turkey). Patients: Sixty type 2 DM outpatients (47 females and 13 males) with PPDN who had a minimum visual analog scale (VAS) score of 40 mm were enrolled in this study. Interventions: Patients randomized to the treatment group (n=30) received venlafaxine HCl, whereas those randomized to the control group (n=30) received a combination of vitamins B-1 and B-6 tablets. Measures: Severity of pain was measured by VAS, Short-Form McGill Pain Questionnaire, and numerical analog scale scores at admission and at the second, fourth, and eighth weeks of the study. Polyneuropathy was supported by electromyelography. Outcome: In the treatment group, severity of pain was measured as 70.0+/-13.0 in the VAS, as 24.9+/-6.2 in the Short-Form McGill Pain Questionnaire, and as 7.2+/-1.1 in the numerical analog scale. In the control group, it was measured as 73.0+/-8.0 in the VAS, as 26.8+/-6.2 in the Short-Form McGill Pain Questionnaire, and as 7.4+/-0.8 in the numerical analog scale (P>.05). Results: The most common form of PPDN was distal symmetrical sensorimotor polyneuropathy in both groups (46.8% vs. 50.0%). At the end of the study, there was a significant difference in severity of pain between the groups. In the treatment group, scores were 8.5+/-5.2 and 3.1+/-1.6 in the Short-Form McGill Pain Questionnaire and numerical analog scale, respectively; in the control group, these were 20.5+/-7.0 and 5.5+/-1.6, respectively (P<.001). Conclusions: Venlafaxine HCl is a safe and well-tolerable analgesic drug in the symptomatic treatment of PPDN; however, it has minimal adverse effects. It showed its efficacy markedly in the second week of therapy. (C) 2008 Elsevier Inc. All rights reserved.Öğe The effects of losartan on the oxidative stress index and thiols in patients undergoing dialysis treatment(Oxford Univ Press, 2007) Kadiroglu, Ali Kemal; Kayabasi, Hasan; Sit, Dede; Kara, I. Hamdi; Yilmaz, M. Emin[Abstract Not Available]Öğe The effects of nebivolol on serum levels of malonyldialdehyde and paraoxonase in patients with end stage renal disease(Oxford Univ Press, 2007) Sit, Dede; Kayabasi, Hasan; Kadiroglu, Ali Kemal; Yilmaz, Zulfikar; Yilmaz, M. Emin[Abstract Not Available]Öğe Eivaluation of the Nutritional Status and Anthropometric Measurements in Continuous Ambulatory Peritoneal Dialysis (CAPD) Patients According to the Anemia Status(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2007) Kadiroglu, Ali Kemal; Sit, Dede; Kayabasi, Hasan; Yilmaz, Zulfukar; Yilmaz, M. EminNutritional biochemical markers such as serum albumin and anthropometric measurements such as BMI are valid and useful tools in assessing the nutritional status in dialysis. Forty-two patients on CAPD therapy were enrolled in the study. Anemic patients and patients who were al target hematocrit levels were evaluated by nutritional parameters and anthropometry. Gender, age, duration of CAPD, dialysis adequacy, educational and economic status had significant affect on BMI and serum albumin. There were positive significant correlations between hematocrit levels and BMI (r=0.331, p=0.0032), and FM (r=.0.383, p=0.012), and MAMC (r=0.365, p=0.017I and serum albumin levels (r=0.416. p=0.006). Achieving target hematocrit levels may improve BMI and MAMC, but not biochemical parameters.Öğe The evaluation incidence and risk factors of mortality among patients with end stage renal disease in Southeast Turkey(Taylor & Francis Ltd, 2008) Sit, Dede; Kadiroglu, Ali Kemal; Kayabasi, Hasan; Kara, Ismail Hamdi; Yilmaz, Zulfukar; Yilmaz, M. EminAim. End stage renal disease (ESRD) presents with higher morbidity and mortality with respect to the general population. In recent study, the causes of mortality and associated risk factors in ESRD have been evaluated. Materials and Methods. In this study, 1538 patients diagnosed with ESRD in 10-year period were evaluated retrospectively. The patients were divided as dead (group 1) and alive (group 2). The patients' demographic features, causes of death, comorbidity at hospitalization, hematological and biochemical analyses, creatinine clearance at the beginning of hospitalization, daily urine volume, blood gas results, CRP value as inflammatory marker, ejection fraction, interventricular septum diameter, left ventricle posterior wall end-diastolic diameter, and left atrium diameter determined with echocardiography were recorded. Results. Mortality ratio of ESRD patients in a 10-year period was 14.1%. While the general mean age of all patients was 54.7 +/- 16.6 and male/female ratio was 781/757, these ratios were 66.3 +/- 21.8 and 114/103 in Group 1 and 52.8 +/- 21.7 and 667/654 in Group 2. One or more comorbid pathologies were present in 82.9% of Group 1. The most common cause of mortality was cardiovascular diseases (CVD), and the most common cause of comorbidity was infections. Older age, anemia, absence of residual renal function, hypoalbuminemia, inflammation, impaired Ca and P metabolism, and left ventricular hypertrophy were significantly higher in Group 1 than in Group 2. Conclusion. CVD are the most important preventable causes of morbidity and mortality in all stages of chronic kidney disease. Taking precaution against CVD and the associated complications will provide a positive contribution in reducing morbidity and mortality among ESRD patients.Öğe The evaluation of effects of demographic features, biochemical parameters, and cytokines on clinical outcomes in patients with acute renal failure(Taylor & Francis Ltd, 2007) Kadiroglu, Ali Kemal; Sit, Dede; Atay, A. Engin; Kayabasi, Hasan; Altintas, Abdullah; Yilmaz, M. EminAim. To evaluate the effects of cytokines, biochemical parameters and demographic features on clinical outcomes of acute renal failure (ARF). Patients and Methods. 59 patients with acute renal failure (28 men, 31 women) were enrolled to the study. Cytokines, biochemical parameters, and complete blood count were measured. Patients were divided into two groups: as survivors (group 1, n = 46) and nonsurvivors (group 2, n = 13). Results. Mean age of patients were 52.3 +/- 17.9 years. 46 patients survived (77.9%) and 13 patients died (22. 1 %). There was a statistically significant relationship between IL-2R, IL-6, and TNF-oc levels and mortality rates (p = 0.004, p = 0.016, p = 0.020, respectively) and between TC levels and mortality rates (p = 0.041). In multivariable logistic regression analysis, the effects of proinflammatory cytokines (IL- I beta, IL-2R, IL-6, TNF alpha, CRP, and ESR) on the clinical outcomes in ARF was observed to be statistically significant (r = 0.341, p = 0.005). Conclusion. We realized that in totally demographic features (male gender, advanced age, poor nutritional status), biochemical parameters (TC, albumin, and hemoglobin) and cytokine levels (IL-2R, IL-6, TNF-oc), CRP and ESR may be predictive factors for mortality in patients with ARF.Öğe The Evaluation of the Association Between Serum Cholesterol Levels with Nutritional Parameters and Anthropometric Measures in Non-Diabetic Continuous Ambulatory Peritoneal Dialysis Patients(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2009) Sit, Dede; Kayabasi, Hasan; Kadiroglu, Ali Kemal; Yilmaz, M. EminWe evaluated the association of serum cholesterol levels with nutritional parameters and anthropometric measurements in non-diabetic patients undergoing continuous ambulatory peritoneal dialysis (CAPD) treatment. Thirty-nine (21 males, 18 females) patients were enrolled into the study. The patients were divided into two groups as group 1 (n=20, serum cholesterol >= 200 mg/dl), and group 2 (n=19, serum cholesterol < 200 mg/dl.) according to serum cholesterol levels. A positive correlation was found between serum levels of cholesterol and prealbumin (r=0.428, p=0.007), transferrin (r=0.322, p=0.046), triglyceride (r=0.537, p=0.001), LDLC (r=0.739, p<0.001), and HDL-C (r=0.454, p=0.004), and between BMI and FM (r=0.851, p<0.001), FFM (r=0.503, p=0.001), TBW (r=0.522, p=0.001) and MAMC (r=0.849, p<0.001). BIA in group 1 was higher than group 2 (p = 0.007). No statistical relation was found between serum cholesterol, and the anthropometric measurements. In conclusion, we found a positive correlation between serum cholesterol levels and prealbumin and transferrin but not in anthropometric measurements in CAPD patients. Further, large scale studies are needed to conclude an absolute judgement.Öğe Parameters of oxidative stress and echocardiographic indexes in patients on dialysis therapy(Taylor & Francis Ltd, 2010) Kayabasi, Hasan; Sit, Dede; Atay, A. Engin; Yilmaz, Zulfukar; Kadiroglu, Ali Kemal; Yilmaz, M. EminAim: Quantity of oxidative stress (OS) is enhanced in every stage of chronic renal failure (CRF). OS and its effects on echocardiographic indexes in patients on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) were evaluated. Materials and methods: Thirty-nine patients on CAPD, 32 patients on HD, and 30 healthy individuals with similar demographic features were included. Patients with diabetes mellitus and chronic inflammatory diseases were excluded. Blood samples were collected to examine hematological and biochemical parameters and levels of malonyldialdehyde (MDA), glutathione peroxidase (GSH-px), and superoxide dismutase (SOD) after a 12-hour fasting period in the middle of dialysis week. OS parameters were compared with ejection fraction (EF), interventricular septum diameter (IVSd), left ventricular posterior wall diameter (LVPWd), and left atrium diameter (LAd) determined in M-mod echocardiographic examination. Results: No significant difference was observed between MDA and GSH-px levels of patients and control group; however, SOD levels of patients group were significantly lower (p < 0.0001). SOD levels of patients on HD were lower than that of patients on CAPD (p = 0.039). Negative correlation was detected between MDA and EF (r = -0.380, p = 0.001); SOD has negative correlation with systolic blood pressure (r = -0.265, p = 0.011), diastolic blood pressure (r = -0.230, p = 0.028), phosphorus (r = -0.327, p = 0.001), intact parathyroid hormone (iPTH) (r = -0.259, p = 0.013), C-reactive protein (CRP) (r = -0.235, p = 0.024), fibrinogen (r = -0.342, p = 0.001), and total cholesterol (r = -0.249, p = 0.017); and positive correlation with hemoglobin (r = 0.414, p < 0.001) and albumin (r = 0.367, p < 0.001). MDA was independently related with age (beta = -0.258, p = 0.035), male gender (beta = -0.312, p = 0.004), and EF (beta = -0.461, p < 0.001). No correlation was determined between antioxidants and cardiac indexes. Conclusion: SOD levels decreased significantly especially in patients on HD, and it was observed that lower levels of SOD would lead to OS in patients on HD and CAPD when compared to healthy individuals; MDA levels were independently influenced from EF.Öğe Periodontitis is an important and occult source of inflammation in hemodialysis patients(Karger, 2006) Kadiroglu, Ali Kemal; Kadiroglu, Ela Tules; Sit, Dede; Dag, Ahmet; Yilmaz, M. EminAim:To evaluate the association between C-reactive protein (CRP) levels and the periodontal status of hemodialysis (HID) patients. Methods: 41 HID patients on rHuEPO therapy were enrolled in the study. Hematologic and biochemical parameters and CRP levels were recorded. The plaque index, gingival index, probing pocket depth and periodontal disease index were used to identify periodontal disease. The patients were divided into 2 groups: group 1 (n = 21), high CRP, and group 2 (n = 20), normal CRP. Results: After periodontal therapy, while the mean CRP level and erythrocyte sedimentation rate declined from 30.46 to 10.36 (p = 0.001) and from 93.4 to 35.8 mg/l (p = 0.001), respectively, the hemoglobin level increased from 9.4 to 10.6 g/dl (p = 0.009) and hematocrit level from 28.2 to 32.0% (p = 0.008) in group 1. Conclusion: Periodontitis is an important and occult source of chronic inflammation and increases the CRP levels in HD patients. Periodontitis can cause hyporesponsiveness to rHuEPO treatment and decrease the hemoglobin levels. Copyright (c) 2006 S. Karger AG, BaselÖğe Plasma cytokine levels in ulcerative colitis(H G E Update Medical Publishing S A, 2007) Goral, Vedat; Celenk, Tahir; Kaplan, Abdurahman; Sit, DedeBackground/Aims: Some immunological factors are responsible in the pathogenesis of ulcerative colitis. There is a relationship between cytokines and ulcerative colitis. Methodology: In this study 20 ulcerative colitis patients (mean age 36.2 years old, 9 women, 11 men) and 20 healthy control groups (mean age 27.2 years old, 11 women, 9 men) were involved in the study. Results: We established that IL-2Rsp, IL-6, IL-8 and IL-10 levels were different at the patients and control groups (p < 0.005). TNF-alpha and IL-1 beta were similar at the both groups. Conclusions: According to these results, IL-2Rsp, IL-6, II-8 and IL-10 play an important role in the pathogenesis of ulcerative colitis. We consider that these cytokines are beneficial parameters in the diagnosis, treatment and prognosis of ulcerative colitis.Öğe Prevalance of ACE Gene Polymorphism in Patients with End Stage Kidney Disease in Southeastern Turkey(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2007) Zerman, Avar; Sit, Dede; Kadiroglu, Ali Kemal; Kayabasi, Hasan; Budak, Metin; Yilmaz, Zi. Ilflikar; Yilmaz, M. EminAim: To evaluate the frequency of angiotensin converting enzyme gene polymorphism from renin angiotensin aidosterone system in patients undergoing chronic dialysis. Materials and Methods: Eighty-seven patients undergoing di;. alysis treatment and 38 healthy volunteers were enrolled in the study. Demographic features, arterial blood pressure, body mass index (BMI, hematological and biochemical parameters were recorded. ACE gene polymorphism was studied using sterile polymerase chain reaction (PCM method from blood samples taken into tubes containing EDTA. Results: Of the 87 patients, 49 were undergoing hemodialysis and 38 were on peritoneal dialysis programme. In the patient group male/female ratio was 48139 and the mean age was 41.11 +/- 13.6 years; in controls male/female ratio was 14,24 and the mean age was 38.0 +/- 1.41 years. Diabetes mellitus, hypertension, chronic glomerulonephritis were the first three causes of ESRD with percentages of 28, 24, and 23% respectively. Systolic and diastolic blood pressures were higher in patients than controls. ACE gene (I/D) polymorphism prevalence was found as 0.9%, 44.8%, 45.9% among patients. and 31.5%, 39.4%, 28.9% among controls for 11/D/DD respectively, and statistical significance was found (p=0.006). ACE D allele frequency was 68.4% among patients, and 48.7% among controls (p=0.001). Conclusion: We found difference in dispersion of ACE genotype and frequency of D allele between patients and controls.
