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Öğe CHARACTERISTICS OF PRIMARY GLOMERULAR DISEASE PATIENTS WITH HEMATURIA IN TURKEY: THE DATA FROM TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Sumnu, Abdullah; Turkmen, Kultigin; Cebeci, Egemen; Turkmen, Aydin; Eren, Necmi; Seyahi, Nurhan; Oruc, Aysegul[Abstract Not Available]Öğe Characteristics of primary glomerular diseases patients with hematuria in Turkey: the data from TSN-GOLD Working Group(Springer, 2021) Sumnu, Abdullah; Turkmen, Kultigin; Cebeci, Egemen; Turkmen, Aydin; Eren, Necmi; Seyahi, Nurhan; Oruc, AysegulPurpose Hematuria is one of the most common laboratory findings in nephrology practice. To date, there is no enough data regarding the clinical and histopathologic characteristics of primary glomerular disease (PGD) patients with hematuria in our country. Methods Data were obtained from national multicenter (47 centers) data entered into the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) database between May 2009 and June 2019. The data of all PGD patients over the age of 16 years who were diagnosed with renal biopsy and had hematuria data were included in the study. Demographic characteristics, laboratory and biopsy findings were also recorded. Results Data of 3394 PGD patients were included in the study. While 1699 (50.1%) patients had hematuria, 1695 (49.9%) patients did not have hematuria. Patients with hematuria had statistically higher systolic blood pressure, serum blood urea nitrogen, creatinine, albumin, levels and urine pyuria. However, these patients had statistically lower age, body mass index, presence of hypertension and diabetes, eGFR, 24-h proteinuria, serum total, HDL and LDL cholesterol, and C3 levels when compared with patients without hematuria. Hematuria was present 609 of 1733 patients (35.8%) among the patients presenting with nephrotic syndrome, while it was presented in 1090 of 1661 (64.2%) patients in non-nephrotics (p < 0.001). Conclusion This is the first multicenter national report regarding the demographic and histopathologic data of PGD patients with or without hematuria. Hematuria, a feature of nephritic syndrome, was found at a higher than expected in the PGDs presenting with nephrotic syndrome in our national database.Öğe Epidemiological features of primary glomerular disease in Turkey: a multicenter study by the Turkish Society of Nephrology Glomerular Diseases Working Group(BioMed Central Ltd, 2020) Türkmen, Aydın; Şumnu, Abdullah; Cebeci, Egemen; Yazıcı, Halil; Eren, Necmi; Seyahi, Nurhan; Dilek, Kamil; Dede, Fatih; Derici, Ülver Boztepe; Ünsal, Abdülkadir; Şahin, Garip; Sipahioǧlu, Murat Hayri; Gok, Mahmut; Tatar, Erhan; Dursun, Belda; Sıpahı, Savaş; Yılmaz, Mürvet; Süleymanlar, Gültekin; Ulu, Sena Memnune; Güngör, Özkan; Kutlay, Sim; Bahçebaşı, Zerrin Bicik; Şahin, Ídris; Kurultak, İlhan; Türkmen, Kültigin; Yılmaz, Zülfikar; Kazancıoğlu, Rümeyza Turan; Çavdar, Caner; Candan, Ferhan; Aydın, Zeki; Oygar, Düriye Deren; Gul, Cuma Bulent; Arici, Mustafa; Paydaş, Saime; Taymez, Dilek Güven; Küçük, Mehmet; Trablus, Sinan; Turgutalp, Kenan; Koç, Leyla; Sezer, Siren; Duranay, Murat; Bardak, Simge; Altıntepe, Lütfullah; Arikan, Izzet Hakki; Azak, Alper; Odabaş, Ali Rıza; Şahin, Gülizar Manga; Ozturk, SavasAbstract Background: The largest data on the epidemiology of primary glomerular diseases (PGDs) are obtained from the databases of countries or centers. Here, we present the extended results of the Primary Glomerular Diseases Study of the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group. Methods: Data of patients who underwent renal biopsy and received the diagnosis of PGD were recorded in the database prepared for the study. A total of 4399 patients from 47 centers were evaluated between May 2009 and May 2019. The data obtained at the time of kidney biopsy were analyzed. After the exclusion of patients without light microscopy and immunofluorescence microscopy findings, a total of 3875 patients were included in the study. Results: The mean age was 41.5 ± 14.9 years. 1690 patients were female (43.6%) and 2185 (56.3%) were male. Nephrotic syndrome was the most common biopsy indication (51.7%). This was followed by asymptomatic urinary abnormalities (18.3%) and nephritic syndrome (17.8%). The most common PGD was IgA nephropathy (25.7%) followed by membranous nephropathy (25.6%) and focal segmental glomerulosclerosis (21.9%). The mean total number of glomeruli per biopsy was 17 ± 10. The mean baseline systolic blood pressure was 130 ± 20 mmHg and diastolic blood pressure was 81 ± 12 mmHg. The median proteinuria, serum creatinine, estimated GFR, and mean albumin values were 3300 (IQR: 1467–6307) mg/day, 1.0 (IQR: 0.7–1.6) mg/dL, 82.9 (IQR: 47.0–113.0) mL/min and 3.2 ± 0.9 g/dL, respectively. Conclusions: The distribution of PGDs in Turkey has become similar to that in other European countries. IgA nephropathy diagnosed via renal biopsy has become more prevalent compared to membranous nephropathy. Keywords: Epidemiology, Glomerulonephritis, Kidney biopsy, Primary glomerular diseases; the Turkish Society of Nephrology glomerular diseases (TSN-GOLD) working group, Turkish Society of NephrologyÖğe Greft sağkalımını etkileyen faktörlerin transplant böbrek biyopsileriyle değerlendirilmesi(Dicle Üniversitesi Tıp Fakültesi, 2018) Saygılı, Emre Serdar; Seyahi, Nurhan; Durak, Haydar; Soylu, Hikmet; Cengiz, Mahir; Altıparmak, Mehmet RızaAmaç: Uzun dönemdeki surviye ve allograft fonksiyonuna etkili olan faktörler her merkezde farklılıklar gösterebilmektedir. Bu nedenle ünitemizden takipli renal allograft biyopsi yapılmış olan hastaların biyopsi sonuçları ve greft sağ kalımları arasındaki ilişkilerin değerlendirilmesi amaçlanmıştır. Yöntemler: 70 hastaya yapılan 94 adet biyopsi retrospektif olarak incelemiştir. Ultrason rehberliğinde tek kullanımlık 16G otomatik iğne ile 2 kore biyopsi alınmıştır. Her biyopsi ışık mikroskopisi ve immunfloresan boyama ile incelenmiştir. Hastalar akut selüler rejeksiyon (ASR), kalsinörin inhibitörü(KNI) toksisitesi, intersitisyel fibrozis tübüler atrofi (IFTA), akut tubüler hasar(ATH) ve greft kaybı gelişenler olarak gruplara ayrılarak alt analizleri yapılmıştır. Bulgular: Toplamda 34(%36,2) biyopsi ile en sık tespit edilen patolojiyi akut selüler rejeksiyon oluşturmaktadır. IFTA, ATH, nüks/de novo glomerülonefrit biyopsi sayıları sırasıyla 21(%22,3), 20(%21,3), 15(%16) olarak bulunmuştur. Akut rejeksiyon öyküsü olanlarda greft sürvisinin daha kısa olduğu tespit edilmiştir (p<0.05). Greft kaybı olan grupta IFTA daha fazla görülmüştür. (p<0.05). Surviler logrank testi ile IFTA ya göre kıyaslandığında istatistiksel anlamlılığını yitirmiştir. Çalışmaya alınan hastalarda KNI toksisitesi, ATH ile greft sürvileri arasında anlamlı fark tespit edilememiştir. Biyopsi sırasındaki albümin seviyesi greft kaybı olan grupta anlamlı olarak daha düşük bulunmuştur (p<0.05). Sonuç: Biyopsilerin yaklaşık üçte birinde öntanıdan farklı bir tanı ile karşılaşılmıştır. Bu da biyopsi olmadan diğer klinik ve laboratuvar bulguların yetersizliğini göstermektedir. Greft survisini ön görmede biyopsi önemli yer teşkil etmektedir. Non-invaziv olarak biyopsi öncesi bakılan serum albumin seviyesi greft kaybını öngörmede bir parametre olarak değerlendirilebilir.Öğe THE IMPORTANCE OF COMPLEMENT LEVELS AND CLINICAL CHARACTERISTICS OF PRIMARY MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS IN TURKEY(Oxford Univ Press, 2020) Tatar, Erhan; Oygar, Deren; Seyahi, Nurhan; Eren, Necmi; Canturk, Yagmur; Gungor, Ozkan; Derici, Ulver[Abstract Not Available]Öğe IS THE SEVERITY OF GLOMERULAR IGG STAINING IN PATIENT WITH IGA NEPHROPATHY USEFUL FOR PREDICTING POOR RENAL PROGNOSIS? THE DATA FROM TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Turgutalp, Kenan; Cebeci, Egemen; Turkmen, Aydin; Derici, Ulver; Seyahi, Nurhan; Eren, Necmi; Dede, Fatih[Abstract Not Available]Öğe The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group(BioMed Central Ltd, 2021) Turgutalp, Kenan; Cebeci, Egemen; Türkmen, Aydın; Derici, Ülver Boztepe; Seyahi, Nurhan; Eren, Necmi; Dede, Fatih; Güllülü, Mustafa; Baştürk, Taner; Şahin, Gülizar Manga; Yılmaz, Mürvet; Sipahi, Savaş; Şahin, Garip; Ulu, Sena Memnune; Tatar, Erhan; Gündogdu, Ali; Kazancıoğlu, Rümeyza Turan; Sevinç, Can; Güngör, Özkan; Şahin, İdris; Kutlay, Sim; Kurultak, İlhan; Aydın, Zeki; Altun, Bülent; Dursun, Belda; Yılmaz, Zülfükar; Uzun, Özcan; Süleymanlar, Gültekin; Candan, Ferhan; Sezer, Siren; Tanburoğlu, Derya Basak; Bicik, Zerrin; Taymez, Dilek Güven; Akcali, Esra; Oygar, Düriye Deren; İstemihan, Zülal; Bardak, Simge; Bardak, Simge; Akçay, Ömer Faruk; Dincer, Mevlüt Tamer; Dervişoğlu, Erkan; Yenigün, Ezgi Çoşkun; Türkmen, Kültigin; Özturk, SavaşBackground: Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods: A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results: 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = − 0.084, r = − 0.102, r = − 0.006, r = 0.062, r = 0.014, r = − 0.044, r = − 0.061, r = − 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion: Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.Öğe THE RELATIONSHIP BETWEEN SEVERITY OF INTERSTITIAL FIBROSIS AND ANEMIA IN PATIENT WITH PRIMARY GLOMERULONEPHRITIS: THE DATA FROM TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Cebeci, Egemen; Turgutalp, Kenan; Ozturk, Savas; Ozluk, Yasemin; Bek, Sibel Gokcay; Sumnu, Abdullah; Seyahi, Nurhan[Abstract Not Available]Öğe TRENDS OF PRIMARY GLOMERULAR DISEASE IN TURKEY FROM 2009 TO 2017: A REGIONAL REGISTRY REPORT FROM TSN-GOLD WORKING GROUP(Oxford Univ Press, 2020) Gul, Cuma Bulent; Kucuk, Mehmet; Ozturk, Savas; Demir, Erol; Eren, Necmi; Sumnu, Abdullah; Seyahi, Nurhan[Abstract Not Available]
