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    RELATIONSHIP BETWEEN SERUM LIPIDS AND COLON POLYPS: A PILOT STUDY
    (Carbone Editore, 2014) Kayatas, Kadr; Kaya, Ozhan; Senates, Ebubekr; Yesil, Atakan; Senates, Banu Erkalma; Yesil, Ezgi Ersoy; Belen, Erdal
    Background/Aim: The relationship between dyslipidemia and various malignancies is still unclear. We therefore investigated the possible relationship between atherogenic dyslipidaemia and colon polyps and assessed the predictive role of dyslipidaemia in the development of colorectal cancer. Methods: The study involved patients evaluated at the Gastroenterology Clinic of HaydarpasaNumune Training and Research Hospital between October 2, 2011, and November 16, 2012. Data were collected from 74 patients with colon polyps (advanced and low-grade dysplasia [LGD]) and 57 healthy control subjects. Results: Triglyceride (p=0.001) and high-density lipoprotein (HDL)-cholesterol (p<0.01) concentrations were significantly higher in patients with advanced dysplasia (AD) than in the control group. Triglyceride (p=0.001) and HDL-cholesterol (p<0.01) concentrations were also significantly higher in patients with LGD than in the control group. Triglyceride and HDL-cholesterol concentrations, however, were similar in the AD and LGD groups. Conclusions: Atherogenic dyslipidaenzia is significantly associated with adenoma, suggesting that it could be involved in adenoma development. Atherogenic dyslipidaemia should not be ignored in colorectal cancer prevention programs.
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    Öğe
    SYMPTOMATIC HYPOCALCAEMIA FOLLOWING INTRAVENOUS ADMINISTRATION OF ZOLEDRONIC ACID IN A FEMALE PATIENT WITH OSTEOPOROSIS
    (Carbone Editore, 2015) Senates, Banu Erkalma; Dogan, Abdullah; Senates, Ebubekir
    Bisphosphonates (BPs) are widely used in the treatment of postmenopausal osteoporosis. Zoledronic acid has the highest affinity with the bone as well as alters mineral surface properties, allowing greater adsorption. A 58-year-old woman presented with osteoporosis, was treated with a once-a-year IV of 5 mg of Zoledronic Acid. Before this once-a-year treatment, her serum calcium levels were normal although after the treatment, she was hospitalized with nausea, perioral and acral paresthesias and tingling. Biochemical analysis recorded Calcium levels as 5.94 mg/dl and low levels of vitamin D Serum. The Hypocalcaemia was initially treated with IV Calcium Gluconate solution followed by oral calcium and vitamin D supplements.