Yazar "Sen, Hadice" seçeneğine göre listele

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    Clinical characteristics and treatment outcomes in 132 patients with malignant mesothelioma
    (Medknow Publications & Media Pvt Ltd, 2011) Abakay, Abdurrahman; Tanrikulu, Abdullah C.; Kaplan, Muhammet Ali; Kucukoner, Mehmet; Abakay, Ozlem; Sen, Hadice; Isikdogan, Abdurrahman
    Purpose: Our objective is to scrutinize clinical, laboratory, radiological characteristics, treatment regimens, and treatment outcomes of malignant mesothelioma (MM) cases in our hospital. Materials and Methods: We investigated, retrospectively, the clinical characteristics and treatment outcomes of all 132 MM patients at Dicle University Hospital between January 2006 and April 2010. Results: A total of 82 (62.1%) patients were male, and 50 (37.9%) female. Median age was 56.0 years. Mean survival time was 9.66.9 months. Mean survival time of patients who had received best supportive care was 7.5 months, chemotherapy 10.4 months, and multimodality treatment regimen 12.6 months. Patients in the multimodality treatment group survived longer than did those in the other two groups (P=0.042). A total of 76 patients received chemotherapy, of whom 17 (22.3%) were administered Cisplatin/Carboplatin and Gemcitabine, 58 (76.4%) Cisplatin/Carboplatin and Pemetrexed, and one (1.3%) Cisplatin Docetaxel. Complete and partial response to treatment in patients receiving Cisplatin/Carboplatin and Gemcitabine was found 47.1% and Cisplatin/Carboplatin and Pemetrexed was found 50.0% (P>0.05). Conclusions: MM related to asbestos exposure is seen frequently in Turkey. Patients present with the typical clinical features of dyspnea, weight loss, and chest pain. Survival analysis shows that patients receiving multimodality treatment may be better.
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    Effect of cigarette smoking on nasal mucociliary transport rate: Rhinoscintigraphic evaluation with using 99mTc-macroaggregated albumin
    (Drunpp-Sarajevo, 2012) Dostbil, Zeki; Dag, Yusuf; Abakay, Abdurrahman; Bakir, Salih; Sezgi, Cengizhan; Abakay, Ozlem; Sen, Hadice
    Objectives: Cigarette smoking has harmful effects on mucociliary transport (MCT) in respiratory system. We aimed to investigate the association between nasal mucociliary transport rate (NMTR) and duration and amount of smoking in chronic cigarette smokers. Materials and Methods: Fifty four current cigarette smokers and 40 healthy non-smokers were included in this study. In all cases, we measured the NMTR using Tc-99m-macroaggregated albumin (Tc-99m-MAA) rhinoscintigraphy. Results: The mean NMTR of the smokers was lower than that of the healthy non-smoker controls (5.63 +/- 2.78; 9.44 +/- 2.09, respectively) (p<0.0001). There were not statistically significant correlation between NMTRs and year of smoking, and smoking pack-year in smokers (p>0.05; r=0.003, r=-0.2, respectively) whereas there was a statistically significant correlation between NMTRs and cigarettes per day in smokers (p=0.024; r=-0.307). Conclusions: Our findings demonstrated that cigarette smoking decreases the nasal NMTR in chronic term. Impaired mucociliary transport in respiratory system may have harmful effects on the human health. The degree of impairment in NMTRs in smokers may increase as the number of cigarettes per day increases.
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    Two cases of extrapulmonary onset granulomatosis with polyangiitis which caused diffuse alveolar haemorrhage
    (Elsevier Science Bv, 2014) Kaya, Halide; Yilmaz, Sureyya; Sezgi, Cengizhan; Abakay, Ozlem; Taylan, Mahsuk; Sen, Hadice; Demir, Melike
    Granulomatosis with polyangiitis (GPA) is a rare form of vasculitis. Multidisciplinary therapeutic approach and early diagnosis assume vital importance in management of patients with diffuse alveolar haemorrhage caused by GPA, which is a rare complication. The purpose of this study was to present the diagnostic and therapeutic challenges experienced by clinicians in management of two severe cases of GPA with insidious extrapulmonary manifestations which rapidly progressed into acute kidney injury, alveolar haemorrhage and acute respiratory failure. (C) 2014 The Authors. Published by Elsevier Ltd.