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Öğe Comparison of the effects of Losartan and Nebivolol on oxidative stress in patients with end stage renal disease(Oxford Univ Press, 2007) Kayabasi, Hasan; Kadiroglu, Ali Kemal; Sit, Dede; Selek, Sahabettin; Yilmaz, M. Emin[Abstract Not Available]Öğe Effect of oxidative stress on antioxidant enzyme activities, homocysteine and lipoproteins in chronic kidney disease(Springer Heidelberg, 2008) Atamer, Aytac; Kocyigit, Yuksel; Ecder, Sabahat Alisir; Selek, Sahabettin; Ilhan, Nevin; Ecder, Tevfik; Atamer, YildizBackground: Our aim was to determine the association of paraoxonase (PON1), superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) concentration, with lipoprotein and homocysteine (Hcy) concentrations in chronic kidney disease (CKD). Methods: We examined 60 patients with CKD (35 men and 25 women), aged 52.7 +/- 3.1 years, and 60 age-, sex- and body mass index (BMI)-matched control subjects. Serum PON1 activity, levels of lipoproteins, Hcy and MDA were evaluated; SOD and CAT activities in erythrocytes were also investigated. Results: Levels of MDA, lipoprotein (a) (Lp(a)) and Hcy were significantly higher, while PON1 activity was lower in CKD than in controls (p<0.001). There were no significant differences between the patients and controls in the SOD and CAT activities (p>0.05). Levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) were lower in CKD than in controls (p<0.001), whereas total cholesterol (T-Chol) and triglyceride (TG) levels showed no significant difference between the groups. Levels of apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) were higher in CKD than in controls (p<0.001). In CKD, PON1 activities were correlated with levels of Hcy, MDA, HDL-C, Lp(a) and ApoA-I. A significant positive correlation was found between levels of Hcy and Lp(a). Conclusions: The results of this work suggest that patients with CKD exhibit an oxidant-antioxidant imbalance which is closely related to high levels of atherosclerotic risk factors.Öğe The evaluation of antioxidant and anticancer effects of Lepidium Sativum Subsp Spinescens L. methanol extract on cancer cells(C M B Assoc, 2018) Selek, Sahabettin; Koyuncu, Ismail; Caglar, Hifa Gulru; Bektas, Ibrahim; Yilmaz, Mustafa Abdullah; Gonel, Ataman; Akyuz, EnesIn recent years, there is an increased research interest for plants which are natural sources of antioxidants. Lepidium sativum Subsp spinescens L., commonly found in South West Asia, is a plant known as a healthy nutritional source containing bio-molecules that carry anti-hypertensive, hypoglycemic, antiasthmatic, antispasmodic, hepato-protective, chemoprotective, anti-inflammatory and anti-oxidant effects. In this study, we aimed to investigate the antioxidant content and activity of Lepidium sativum Subsp spinescens L. methanol extract on cancer cells. Methanol extract of dried Lepidium sativum Subsp spinescens L. was prepared. Total amount of phenolic compounds was determined by Slinkard and Singleton method using Folin-Ciocalteu reagent. Total flavonoid amount was determined according to Zhishen method. Antioxidant activity of the extract was evaluated by CUPRAC and ABTS radical scavenging activity assays. Cytotoxic effects of the plant extract on colon and endometrium cancer cells, and human peripheral lymphocyte cells were investigated in vitro by MTT and neutral red assays. Furthermore, the plant extract was investigated for necrotic effects by LDH assay; apoptotic activity by DNA ladder fragmentation, ELISA and acridine orange/ethidium bromide staining; and genotoxic effect by comet assay methods. Methanol extract of Lepidium sativum Subsp spinescens L. was found to have a high content of phenolic and flavonoid compounds. The extract showed significant antioxidant activity and also cytotoxic activity on colon and endometrium cancer cells in a concentration-dependent manner. Apoptotic activity and genotoxic effects were significantly increased, especially with 200 mu g/ml concentrations at 48 hours incubation. In conclusion, it was determined that the extract evaluated in this study could be a natural source of antioxidants. Further molecular studies explaining chemo-preventive and chemotherapeutic effects on cancer cells are required to support anticancer efficacy of the plant.Öğe Paraoxonase and arylesterase activities in fibromyalgia(Taylor & Francis Ltd, 2007) Altindag, Ozlem; Gur, Ali; Calgan, Nazife; Soran, Neslihan; Celik, Hakim; Selek, SahabettinPublished by Maney Publishing ( c) W. S. Maney & Son Limited We aimed to evaluate the association of serum paraoxonase and arylesterase activities and oxidative/ antioxidative status in patients with fibromyalgia. Forty-two patients with fibromyalgia and 53 healthy controls were included in the study. Serum paraoxonase and arylesterase activities were measured spectrophotometrically. Oxidative and antioxidative status were evaluated by measuring serum lipid hydroperoxide ( LOOH) levels, total antioxidant status ( TAS) and free sulfhydryl groups ( - SH = total thiol). Lipid parameters were determined by routine laboratory methods. Serum paraoxonase and arylesterase activities, and TAS were lower in patients with fibromyalgia than in controls ( P < 0.001, for all), and the - SH level was also lower in the patient group ( P = 0.03). LOOH levels were higher in the patient group than in controls ( P = 0.01). Our results suggest that patients with fibromyalgia were exposed to oxidative stress, and paraoxonase and arylesterase activities were decreased in these patients. Patients with fibromyalgia might be prone to development of atherosclerosis with reduced paraoxonase and arylesterase activities.Öğe Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress(Taylor & Francis Ltd, 2012) Yesilova, Yavuz; Turan, Enver; Ucmak, Derya; Selek, Sahabettin; Yavuz, Brahim Halil; Tanrikulu, OsmanVitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases.
