Paraoxonase and arylesterase activities in fibromyalgia
[ X ]
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Published by Maney Publishing ( c) W. S. Maney & Son Limited We aimed to evaluate the association of serum paraoxonase and arylesterase activities and oxidative/ antioxidative status in patients with fibromyalgia. Forty-two patients with fibromyalgia and 53 healthy controls were included in the study. Serum paraoxonase and arylesterase activities were measured spectrophotometrically. Oxidative and antioxidative status were evaluated by measuring serum lipid hydroperoxide ( LOOH) levels, total antioxidant status ( TAS) and free sulfhydryl groups ( - SH = total thiol). Lipid parameters were determined by routine laboratory methods. Serum paraoxonase and arylesterase activities, and TAS were lower in patients with fibromyalgia than in controls ( P < 0.001, for all), and the - SH level was also lower in the patient group ( P = 0.03). LOOH levels were higher in the patient group than in controls ( P = 0.01). Our results suggest that patients with fibromyalgia were exposed to oxidative stress, and paraoxonase and arylesterase activities were decreased in these patients. Patients with fibromyalgia might be prone to development of atherosclerosis with reduced paraoxonase and arylesterase activities.
Açıklama
Anahtar Kelimeler
Fibromyalgia, Paraoxonase, Arylesterase, Oxidative Stress
Kaynak
Redox Report
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
12
Sayı
3
