Yazar "Seilkhanov, Tulegen" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Enhancing aseptic inflammation resolution with 1-(2-Ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate: A novel β-Cyclodextrin complex as a therapeutic agent
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024) Zhumakova, Symbat; Tokusheva, Aliya; Zharkynbek, Tolganay; Balabekova, Marina; Kõks, Sulev; Seilkhanov, Tulegen; Dembitsky, Valery; Aydemir, Murat
    The synthesized compound, 1-(2-ethoxyethyl)-4-(pent-1-yn-1-yl)piperidin-4-yl propionate (EPPP), and its 1:1 complex with β-cyclodextrin (EPPPβCD) have been characterized for the first time through a comprehensive suite of analytical methods. This study explores the therapeutic potential of EPPPβCD in modulating immune responses and accelerating the resolution of septic inflammation induced by chromium and vanadium ions in outbred male rats. The research highlights the significant impact of EPPPβCD on the dynamics of regulatory T lymphocytes (Tregs), notably causing a reduction in the CD4+CD25+ fractions at the onset of inflammation. This effect is attributed to the inhibition of Treg proliferation, which is crucial in hastening the resolution of inflammation. These findings underscore the potential of EPPPβCD as a promising therapeutic agent in controlling and mitigating inflammation mediated by heavy metal exposure, thereby offering a new avenue for the development of anti-inflammatory treatments.
  • Küçük Resim
    Öğe
    NMR study of the inclusion complexes of beta-cyclodextrin with diphenhydramine, clonidine and tolperisone
    (Springer International Publishing AG, 2022) Zhumakova, Symbat; Ten, Assel; Zharkynbek, Tolganay; Yu, Valentina; Seilkhanov, Tulegen; Basharimova, Anna; Bayazit, Sarah; Aydemir, Murat; Zazybin, Alexey
    Forming complexes with beta-cyclodextrin can enhance stability, dissolution rate, solubility, and bioavailability of an active pharmaceutical ingredient. In this study, the inclusion behavior between beta-cyclodextrin (beta-CD) and diphenhydramine, clonidine, and tolperisone in DMSO-d(6) was investigated using NMR spectroscopy. H-1, C-13, COSY, HMQC, and ROESY data were applied to determine the structure of inclusion complexes, and molecular docking analysis was engaged to identify the most favorable host-guest interactions in the inclusion complexes. Complexation of beta-CD with diphenhydramine, clonidine, and tolperisone is accompanied by the insertion of a molecular fragment of the guest molecule, one molecule of diphenhydramine and tolperisone, and two molecules of clonidine, into the inner sphere of one host molecule. The reported study provides useful information for the potential application of the complexation of beta-CD with diphenhy-dramine, clonidine, and tolperisone. This may be a good strategy for the development of solid pharmaceutical dosage forms based on beta-CDs as a drug delivery system.