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Öğe Effects of nimodipine on the cerebrovascular and neuronal changes during pneumococcal meningitis in the rat(Akademiai Kiado Rt., 1997) Hoşoglu S.; Ceviz A.; Serdar Kemaloglu M.; Sari I.; Inalöz S.; Geyik M.F.; Kökoglu Ö.F.It was investigated whether treatment with the calcium channels blocker Nimodipine, a 1,4-dihydropyridine derivative, influences vasculopathy and neuronal injury in experimental pneumococcal meningitis. Rats were randomly assigned to one of three experimental groups. The first group (Control group, n=20) was given saline (0.4 ml/day) intraperitoneally (ip), whereas the second group (group C, n=22) was treated only with ceftriaxone in a dosage of 30 mg/day/ip. The third group (group C-N, n=22) was treated with the combination of ceftriaxone 30 mg/day/ip, and nimodipine 0.6 mg/day/ip. Treatment was begun at the time of inoculation in all three groups. The control group was compared clinically and histopathologically with groups C and C-N at 24 h, three and six days after inoculation. Six rats in the control group and eight rats in group C and group C-N were sacrificed at 24 hours and seven rats in each group were sacrificed on the third and sixth day after inoculation. Clinically, there were no significant differences between group C and group C-N (p>0.05). There were significant differences between group C and group C-N for vasculopathy and neuronal injury (p<0.0001 and p<0.005, respectively). © 1997 Akadémiai Kiadó.Öğe Nitrendipine and stress-induced ulcers: Preliminary tudy(1997) Inalöz S.; Ozaydin M.; Sari I.; Cicek R.; Guney B.; Yenice N.Nitrendipine is a derivative of the dihydropyridine of calcium channel blockers and released for angina and hypertension. The therapeutic effect of nitrendipine was observed histologically against stress-induced gastric and duodenal ulcers in rats. Twenty-four male Wistar-albino rats were separated into three groups (n = 8), a control (non-stress) and two stress groups. The stressed group rats were exposed to starvation and cold-restraint in this study. The first stress group was given only a placebo whereas the second stress group was treated with nitrendipine. After treatment with nitrendipine, the total rea of the affected lesional mucosa was considerably reduced in both duodenal and gastric mucosa. Macroscopically, the surface area of the affected lesional mucosa was measured as 1/5 of the total duodenal mucosa. Moreover, the surface area of the affected lesional mucosa was measured as 1/8 of the total surface area in the stomach. In microscopic examination, tissue regeneration was conspicuous particularly in the gastric epithelium. A few hyperchromatic epithelial cells were noticed in some fields of the duodenal mucosa. Furthermore, tissue regeneration was not conspicuous as in the gastric mucosa. So we think that nitrendipine can be used in both gastric and duodenal stress ulcer treatment. However, in the healing process, therapeutic effect of nitrendipine was superior in stomach with conspicuous tissue regeneration.Öğe Omeprazole, nitrendipine, famotidine and stress-induced ulcers(1997) Inaloz S.S.; Canberk Y.; Ozaydin M.; Sari I.; Yenilmez E.; Ulak G.; Goral V.Background: Omeprazole inhibits gastric acid secretion by blocking the proton pomp of the gastric parietal cell. Nitrendipine is a derivative of dihydropyridine group of calcium channel blockers and administrated for angina and hypertension. Famotidine is one of the newer histamine H2 receptor antagonists and heals gastric and duodenal ulcers by reducing gastric acid output. Objectives: The healing effects of omeprazole, nitrendipine and famotidine on stress-induced gastric ulcers were investigated in rate. Methods: Forty male Wistar-albino rats were separated into five groups (n=8), a control (non-stress) and four experimental (stress) groups. Experimental rats were treated with omeprazole, nitrendipine, famotidine or a placebo after the stresses of starvation and cold-restraint. Results: Macroscopically, the mean area of the affected lesional mucosa was 1/4 of the total gastric mucosa in the famotidine treated group and 1/5 of the total gastric mucosa in the nitrendipine treated group. A considerably decrease was observed in the omeprazole treated group in which the mean area of the lesional mucosa was only in 1/8 of the total gastric mucosa. On microscopic examination, congestive vessels and chronic inflammatory cell infiltrates were significantly reduced in the omeprazole treated group. Tissue regeneration was more prominent in the omeprazole group than me other groups. Conclusion: Omeprazole was found to be superior in terms of the effect on the healing process to nitrendipine and famotidine. Although therapeutic effects of nitrendipine and famotodine were observed, those were less than omeprazole.Öğe Omeprazole, nitrendipine, famotidine and stress-induced ulcers [1](1997) Inaloz S.S.; Goral V.; Sari I.[No abstract available]
