Effects of nimodipine on the cerebrovascular and neuronal changes during pneumococcal meningitis in the rat
[ X ]
Tarih
1997
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Akademiai Kiado Rt.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
It was investigated whether treatment with the calcium channels blocker Nimodipine, a 1,4-dihydropyridine derivative, influences vasculopathy and neuronal injury in experimental pneumococcal meningitis. Rats were randomly assigned to one of three experimental groups. The first group (Control group, n=20) was given saline (0.4 ml/day) intraperitoneally (ip), whereas the second group (group C, n=22) was treated only with ceftriaxone in a dosage of 30 mg/day/ip. The third group (group C-N, n=22) was treated with the combination of ceftriaxone 30 mg/day/ip, and nimodipine 0.6 mg/day/ip. Treatment was begun at the time of inoculation in all three groups. The control group was compared clinically and histopathologically with groups C and C-N at 24 h, three and six days after inoculation. Six rats in the control group and eight rats in group C and group C-N were sacrificed at 24 hours and seven rats in each group were sacrificed on the third and sixth day after inoculation. Clinically, there were no significant differences between group C and group C-N (p>0.05). There were significant differences between group C and group C-N for vasculopathy and neuronal injury (p<0.0001 and p<0.005, respectively). © 1997 Akadémiai Kiadó.
Açıklama
Anahtar Kelimeler
Kaynak
Acta Microbiologica et Immunologica Hungarica
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
44
Sayı
3
