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    Effect of dietary zearalenone on the performance, reproduction tract and serum biochemistry in young rats
    (Taylor & Francis Ltd, 2017) Denli, Muzaffer; Carlos Blandon, Juan; Salado, Silvia; Elena Guynot, Maria; Francisco Perez, Jose
    The present study was conducted to determine the toxic dose response of a chronic dietary Zearalenone (ZEA) in weaned young rats. Sixty, 21-day-old, Sprague Dawley female rats were randomly allocated to five groups of four replicate cages containing three rats. Rats were fed diets with increasing amounts of ZEA (0, 0.5, 0.9, 1.8 and 3.6 mg/kg) for 4 weeks. Daily feed intake was reduced (P < .05) by feeding the ZEA diets with 0.9 and 3.6 mg ZEA/kg feed. Rats fed the diet containing 1.8 mg ZEA/kg increased (P < .05) the body weight gain (BWG) and reduced (P < .05) feed conversion rate (FCR) as compared to the control group. The two highest levels of dietary ZEA also increased (P < .05) the weight of the uterus. However, ovaries' weight, timing of vaginal opening and the inter-oestrous interval were not affected by increasing the doses of dietary ZEA (P > .05). Similarly, serum concentrations of total protein, follicle-stimulating hormone and alanine aminotransferase, aspartate aminotransferase and alkaline phosphate activities were not altered by the ZEA treatments. In conclusion, our results indicated that a chronic dietary consumption of ZEA at concentrations of 1.8 mg ZEA/kg increases the BWG and the uterus weight of weaning female rats.
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    Efficacy of AdiDetoxTM in reducing the toxicity of fumonisin B1 in rats
    (Pergamon-Elsevier Science Ltd, 2015) Denli, Muzaffer; Blandon, Juan C.; Salado, Silvia; Guynot, Maria E.; Casas, Josefina; Perez, Jose F.
    The objective of this study is to evaluate the efficacy of a new mycotoxin inactivator (AdiDetox(TM)) in reducing the toxic effects of fumonisin B-1(FB1) in the diet of rats. Sixty-four male Sprague-Dawley growing rats (125 g +/- 1 g BW) were assigned to eight dietary treatments for seven days. The experiment had a 2 x 4 factorial arrangement with two levels of FB1 (0 mg and 15 mg of FB1,/kg feed) and four levels of AdiDetox(TM) (0 g, 1 g, 2 g and 5 g /kg feed) in the diet No significant differences were observed in the growth performance among treatments (P > 0.05), though low levels of sphingosine (So) and sphinganine (Sa) were detected in the liver. However, So and Sa and the Sa/So ratio in kidneys were higher in rats receiving the FRI diets (P <0.0001) than in those fed the Control diet. Supplementation of AdiDetox(TM) to the diet significantly reduced the toxic effects of FB1, leading to a significant decrease in the Sa content and in the Sa/So ratio in kidneys. In conclusion, the results suggest that AdiDetox(TM) can effectively reduce toxicity of FB1 in growing rats. (C) 2015 Elsevier Ltd. All rights reserved.